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Institution
Universitätsklinikum Ulm
Institut für Experimentelle und Klinische Pharmakologie,Toxikologie und Naturheilkunde
Address
Albert-Einstein-Allee 11
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Research Grants
Completed projects
Crossing Barriers with bio-based Therapeutics
(Applicant
Otte, Ph.D., Kerstin
)
Identification and characterization of cell membrane receptors of binary actin-ADP-ribosylating toxins
(Applicant
Aktories, Klaus
)
Inhibition of bacterial protein toxins, in particular the toxins of Clostridioides difficile, by factors and cleavage products of the human complement system
(Applicants
Barth, Holger
;
Huber-Lang, Markus
)
Molecular, Biochemical and Functional Analysis of Shiga Toxin and Subtilase Cytotoxin Subunits of Enterohemorrhagic Escherichia coli
(Applicants
Barth, Holger
;
Schmidt, Herbert
)
Molekulare Mechanismen der Interaktion des Tumorsuppressors Merlin mit Rho-GTPasen / Aufklärung von Neurofibromatose (NF-)relevanten Signaltransduktionswegen und Biomarkern mit Protein Mikroarrays
(Applicants
Gierschik, Peter
;
Joos, Thomas
)
Probing temporal sequences and molecular mechanisms of transcription initiation by single molecule fluorescence microscopy in living eukaryotic cells
(Applicant
Gebhardt, Christof
)
Role of peptidyl-prolyl cis/trans-isomerases (PPlases) during uptake of binary bacterial toxins into the cytosol of mammalian cells
(Applicant
Barth, Holger
)
Structure-function analysis of large clostridial cytotoxins
(Applicant
Aktories, Klaus
)
Virusinduzierte Regulation der Genexpression infizierter Wirtszellen
(Applicant
Burysek, Ladislav
)
Priority Programmes
Completed projects
Modification of actin by bacterial protein toxins and effectors
(Applicant
Barth, Holger
)
SPP 312: GTPasen als zentrale Regulatoren zellulärer Funktionen
(Spokesperson
Gierschik, Peter
)
Collaborative Research Centres
Current projects
Biohybrid transporters for cell type-specific delivery and controlled release of pharmacologically active peptides
(Project Heads
Barth, Holger
;
Michaelis, Jens
)
Cellular and molecular responses to trauma-induced damage of the distal respiratory epithelium
(Project Heads
Barth, Holger
;
Frick, Manfred
)
Endogenous peptides as novel inhibitors of the Bordetella pertussis toxin
(Project Heads
Barth, Holger
;
Ernst, Katharina
)
Completed projects
ADP-Ribosylierung von Aktin durch bakterielle Toxine
(Project Heads
Aktories, Klaus
;
Barth, Holger
)
Cell type-selective carriers for targeted pharmacological inhibition of Rho-/actin-dependent leukocyte recruitment into the alveolar space after blunt chest trauma
(Project Heads
Barth, Holger
;
Weil, Tanja
)
Funktionelle Bedeutung des konstitutiv aktiven viralen Chemokinrezeptorhomologs pUS28 in Zytomegalievirus-infizierten Gefäßwandzellen
(Project Heads
Gierschik, Peter
;
Mertens, Thomas
)
Mechanistic basis of CLL resistance to targeted tumor therapy in a pathophysiologically relevant cellular context: role of Rho GTPases and phospholipase C-y2
(Project Head
Gierschik, Peter
)
Molekulare Mechanismen der Aktivierung von Rho-GTPase Rac2 und ihres Effektors Phospholipase C-ß2 in myeloischen Zellen
(Project Head
Illenberger, Daria
)
Molekulare Mechanismen der Signaltransduktion der Chemokinrezeptoren CCR2a und CCR2b: Bedeutung von rezeptorassoziierten Signalmolekülkomplexen
(Project Head
Möpps, Barbara
)
Regulation der gerichteten Migration und Invasion humaner Pankreaskarzinomzellen
(Project Heads
Giehl, Klaudia
;
Gierschik, Peter
)
Regulation der Phospholipase C-Gamma2 durch Rac-GTPasen: Molekulare Mechanismen und physiologische Bedeutung
(Project Heads
Gierschik, Peter
;
Nienhaus, Gerd Ulrich
)
Synthesis of peptide and protein biohybrids with improved features
(Project Heads
Barth, Holger
;
Otto, Markus
;
Weil, Tanja
)
Major Research Instrumentation
Completed projects
Hybrid-FT(Fouriertransformations)-Massenspektrometer mit eindimensionalem, splitfreiem Nano-Ultrahochdruck-Flüssigkeitschromatographie-System
Research Training Groups
Completed projects
GRK 460: Diagnostic and Therapeutic Concepts in Molecular Medicine
(Spokesperson
Lehmann-Horn, Frank
)
GRK 1041: Molecular Diabetology and Endocrinology in Clinical Medicine
(Spokesperson
Böhm, Bernhard Otto
)
GRK 2203: Micro- and nano-scale sensor technologies for the lung
(Spokesperson
Ortmanns, Maurits
)
Graduate Schools
Completed projects
GSC 270: International Graduate School in Molecular Medicine Ulm
(Spokesperson
Kühl, Michael
)
Additional Information
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