SFB 1278:  Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies

• Subject Area: Chemistry ; Biology ; Medicine ; Physics
• Term: from 2017 to 2026
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Tailor-made multifunctional polymers and nanoparticles with optimised compatibility between biodegradable core and encapsulated drug (Project Heads Schubert, Ulrich S. ;  Sierka, Marek )
• A04 - Spatial and temporal targeting of membrane-bound mPGES-1 and FLAP / 5-LO by dual inhibitors employing polymer-based nanocarriers (Project Heads Eggeling, Christian ;  Schubert, Ulrich S. ;  Werz, Oliver )
• A06 - Controlling stealth and barrier breaking behavior: Hybrid protein nanofibers and POxylation on polymeric nanoparticles with structurally tailored thermal properties (Project Heads Jandt, Klaus D. ;  Schubert, Ulrich S. )
• B02 - Macromolecular prodrug nanoparticles for antimicrobial therapy (Project Heads Brakhage, Axel ;  Guerrero Sanchez, Ph.D., Carlos Antioco )
• B03 - Bioinspired guanidinium-containing nanoparticles for gene delivery (Project Heads Fischer, Dagmar ;  Peneva, Ph.D., Kalina )
• B04 - Nanoscale monitoring of surface effects, structural changes, and encapsulation in block copolymer nanostructures using tip-enhanced Raman spectroscopy (Project Heads Deckert, Volker ;  Schacher, Felix H. )
• B08 - The mechanism and the immunomodulatory consequences of protein adsorption on stealth nanoparticles (Project Heads Hellmich, Ute ;  Press, Adrian )
• C01 - Biophotonic characterisation of the interaction of nanoparticles and drugs with hepatic stellate cells (Project Heads Bauer, Michael ;  Popp, Jürgen ;  Schubert, Stephanie )
• C02 - Tailored delivery of anti-inflammatory natural drugs using polymer-based nanocarriers to prevent cytokine and eicosanoid storms in infectious inflammation (Project Heads Fischer, Dagmar ;  Werz, Oliver )
• C04 - Investigation of cellular response to nanoparticle uptake by dual TEM and superresolution fluorescence imaging (Project Heads Heintzmann, Rainer ;  Höppener, Stephanie )
• C06 - Prevention of late phase liver damage by targeted modulation of the liver’s immune response (Project Heads Bauer, Michael ;  Schubert, Ulrich S. ;  Waskow, Claudia )
• D02 - Delivery platforms for antiviral and anti-inflammatory agents targeting infections of respiratory viruses with pandemic potential (Project Heads Ehrhardt, Christina ;  Hoffmann, Carsten ;  Löffler, Bettina ;  Schubert, Stephanie )
• Z01 - Research platform for the synthesis, formulation, and advanced physicochemical characterisation of polymers and nanoparticles (Project Heads Eggeling, Christian ;  Figge, Marc Thilo ;  Guerrero Sanchez, Ph.D., Carlos Antioco ;  Höppener, Stephanie ;  Lorkowski, Stefan ;  Nischang, Ivo )
• Z02 - Integrated Research Training Group (Project Heads Dietzek-Ivansic, Benjamin ;  Schubert, Stephanie ;  Werz, Oliver )
• Z03 - Central tasks of the Collaborative Research Center (Project Head Schubert, Ulrich S. )
• Ö01 - Science education on target: Didactic reconstruction of current research at the interface between nanotechnology and medicine (Project Head Wilke, Timm )

Completed projects

• A02 - Multifunctional nanoparticles based on polysaccharides for targeted drug delivery with two-step release behavior (Project Heads Coldewey, Ph.D., Sina Maren ;  Heinze, Thomas ;  Heinzel, Thorsten )
• A03 - Photoacids and bases as responsive elements in block copolymer nanostructures for uptake and transport (Project Heads Dietzek-Ivansic, Benjamin ;  Jandt, Klaus D. ;  Schacher, Felix H. )
• A05 - Targetable nanoparticles for efficient translocation across gastrointestinal barriers (Project Heads Brendel, Johannes ;  Mosig, Ph.D., Alexander ;  Stallmach, Andreas )
• B01 - Multicomponent nanoparticles for efficient targeting of inflammatory signaling and memory in hematopoietic stem and myeloid cells (Project Heads Rudolph, Karl Lenhard ;  Träger, Anja )
• B06 - Targeted nanoparticle mediated delivery of nucleic acids into muscle stem cells for prevention of critical illness myopathy (Project Head Träger, Anja )
• B07 - Quantitative single-molecule characterization of cytosolic nanoparticle cargo release by multi-colour, threedimensional dSTORM (Project Head Franke, Christian )
• C03 - Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions (Project Heads Bauer, Michael ;  Qualmann, Britta ;  Schacher, Felix H. )
• C05 - Advanced fluorescence microscopy investigations of lipid-membrane nanoparticle interactions (Project Head Eggeling, Christian )
• D01 - Mimicking viral entry mechanisms with polymeric nanoparticles (Project Heads Bauer, Michael ;  Eggeling, Christian ;  Schubert, Ulrich S. )
• T01 - Targeting renal phosphoinositide 3-kinase γ (PI3Kγ) by dye-tagged nanoparticles (Project Heads Bauer, Michael ;  Coldewey, Ph.D., Sina Maren ;  Schubert, Ulrich S. )

• Applicant Institution: Friedrich-Schiller-Universität Jena
• Spokesperson: Professor Dr. Ulrich S. Schubert