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Institution
Universität zu Köln
Department für Chemie
Institut für Biochemie
Address
Otto-Fischer-Straße 12-14
50674 Köln
Deutschland
GERiT
This institution in GERiT
50674 Köln
Projects
Priority Programmes
Current projects
Coordination of proteostasis and mitochondrial intermembrane space protein import
(Applicants
Hoppe, Ph.D., Thorsten
;
Riemer, Jan
)
Completed projects
Mitochondrial and cytosolic maturation of human FeS-dependent molybdenum cofactor synthesis MOCS1A proteins and links between both cofactor pathways
(Applicant
Schwarz, Günter
)
Redox regulation of human adenylate kinase 2 (AK2), an essential key controller of energy metabolism
(Applicant
Riemer, Jan
)
Sensor modules of the osmoregulatory glycine betaine uptake carrier from Corynebacterium glutamicum: structure and interaction with the transport domain Transport-Domäne
(Applicant
Krämer, Reinhard
)
SPP 1070: Struktur funktioneller Module von energiewandelnden Systemen in Prokaryoten
(Spokesperson
Krämer, Reinhard
)
Structure of functional modules from energy-transducing complexes in prokaryotes
(Applicant
Krämer, Reinhard
)
Research Grants
Current projects
Controlling collagen deposition by fibroblasts in cutaneous fibrosis by targeting TANGO1 function
(Applicants
Krieg, Thomas
;
Sengle, Gerhard
)
Exploration and Exploitation of Secondary Sites of Protein Kinase CK2
(Applicants
Jose, Joachim
;
Niefind, Karsten
)
NOVEL TARGETS OF THE SULFHYDRYL : CYTOCHROME C OXIDOREDUCTASE ALR
(Applicant
Riemer, Jan
)
Structural conformations of kainate receptors in physiology and pathophysiology
(Applicant
Brown, Ph.D., Patricia
)
Completed projects
Activation and Inactivation Mechanisms of Membrane-bound Guanylyl Cyclases
(Applicant
Behrmann, Elmar
)
Crystallizations and X-ray structure determination of sulfite oxidas and nitrate reductase (molybdenum domai) from Arabidopsis thaliana
(Applicant
Schwarz, Günter
)
Edelgase und Stickstoff in Mars-Meteoriten als Hinweise zur Entwicklung der Mars-Atmosphäre
(Applicant
Jochum, Klaus Peter
)
Functionalization of LbL-Microcarriers as Drug Delivery System for Elastase Inhibitors and HOCl Scavengers for the Termination of Chronic Inflammation
(Applicant
Reibetanz, Uta
)
Geschlechtsspezifische Regulation der Mitochondrienfunktion im ZNS durch Östrogen im Morbus Parkinson-Tiermodell
(Applicant
Arnold, Susanne
)
Mechanism of selective metal incorporation and cofactor maturation during tungsten cofactor biosynthesis
(Applicant
Schwarz, Günter
)
Mia40 and ALR substrates: initial steps in biogenesis and regulation
(Applicant
Riemer, Jan
)
Molecular mechanisms of nitrate reduction, NO synthesis and post-translational regulation of plant nitrate reductases
(Applicant
Schrader, Katrin
)
Molybdän-Cofaktor-Defizienzen beim Menschen
(Applicant
Schwarz, Günter
)
Nuclear Activities of DNA-Associated Immune Receptors
(Applicants
Niefind, Karsten
;
Parker, Jane E.
)
Regulation der Glucosylglycerol-Konzentration in Synechocystis sp. PCC 6803
(Applicant
Marin, Kay
)
Sensing, signal transduction, and conformational coupling of the transporter BetP and the two component system MtrAB from Corynebacterium glutamicum
(Applicant
Krämer, Reinhard
)
Structural and biochemical characterisation of plant EDS1 disease resistance regulatory complexes
(Applicants
Niefind, Karsten
;
Parker, Jane E.
)
Structural and genetic variability of the proteostasis network in Saccharomyces cerevisiae.
(Applicant
Weith, Matthias
)
Structure-function-correlations of protein kinase CK2
(Applicant
Niefind, Karsten
)
Structure-function relationships in the collagen-specific chaperone Hsp47: Crystal structure, in-vivo and invitro studies and development of antifibrotic agents.
(Applicant
Baumann, Ulrich
)
Structure-function relationships of protein kinase CK2
(Applicants
Niefind, Karsten
;
Pietsch, Markus
)
Struktur und Funktion von Hydroxyprolin-Glykanen in Chlamydomonas reinhardtii
(Applicant
Waffenschmidt, Sabine
)
Studies on the absolute configuration of hydroxy- and epoxyiridals
(Applicant
Marner, Franz-Josef
)
Systematic and comprehensive interdisciplinary analysis of all Martian meteorites - TOF-SIMS investigation
(Applicant
Stephan, Thomas
)
Systematische und umfassende interdisziplinäre Analyse aller Marsmeteorite
(Applicant
Herpers, Ulrich
)
Systematische und umfassende interdisziplinäre Analyse aller Marsmeteorite
(Applicant
Michel, Rolf
)
Systematische Untersuchungen der Stoßwellenmetamorphose aller Marsmeteorite (Systematic investigation of shock metamorphism of all Martian meteorites)
(Applicant
Greshake, Ansgar
)
Tailoring of a membrane-active peptide with dual biological activities
(Applicant
Neundorf, Ines
)
The structural and functional basis of neuroreceptor clustering by gephyrin
(Applicants
Schindelin, Hermann
;
Schwarz, Günter
)
Emmy Noether Independent Junior Research Groups
Completed projects
The regulation of oxidative energy metabolism in astrocytes in coordination with neuronal activity
(Applicant
Arnold, Susanne
)
Collaborative Research Centres
Current projects
Integrated Research Training Group "mito-RTG"
(Project Heads
Dohmen, Jürgen
;
Riemer, Jan
)
Metabolic signaling as a safeguard of translational fidelity
(Project Heads
Ignatova, Zoya
;
Weith, Matthias
)
Mitochondrial Hydrogen Peroxide Signalling
(Project Head
Riemer, Jan
)
Stress-dependent regulation of organellar proteome plasticity by dynamic selection of different translation initiation sites
(Project Head
Riemer, Jan
)
Sulfite-dependent regulation of mitochondrial function by sulfite oxidase
(Project Head
Schwarz, Günter
)
Completed projects
Ferroptosis and regulated cell death in sulphite oxidase deficiency
(Project Head
Schwarz, Günter
)
Functional and structural basis of the 14-3-3 mediated inhibition of plant nitrate reductase activity
(Project Head
Schwarz, Günter
)
Post-translation control of gephyrin clustering at inhibitory synapses: phosphorylation and palmitoylation
(Project Head
Schwarz, Günter
)
Proteolysis as a regulatory principle in GlnK stability and the network of nitrogen control in Corynebacterium glutamicum
(Project Heads
Burkovski, Ph.D., Andreas
;
Krämer, Reinhard
)
Proteolytic degradation by FtsH proteases as regulatory mechanism of stress acclimatisation in cyanobacteria
(Project Heads
Krämer, Reinhard
;
Marin, Kay
)
Structural determinants of avian magnetoreception
(Project Head
Behrmann, Elmar
)
Structure-function analysis of Arabidopsis EDS1 immune signalling complexes
(Project Heads
Niefind, Karsten
;
Parker, Jane E.
)
Structure-function relationships of Hsp47/SERPINH1 and its role in skin fibrosis
(Project Heads
Baumann, Ulrich
;
Sengle, Gerhard
;
Zaucke, Frank
)
Synthese potentieller Inhibitoren fuer Zuckernukleosiddiphosphat-abhaengige Glykosyltransferasen
(Project Head
Legler, Günter
)
Research Units
Completed projects
Markierung von Peptidhormonen mit Metallkomplexen für Tumordiagnostik und -therapie
(Applicants
Beck-Sickinger, Annette G.
;
Neundorf, Ines
)
Mechanism of insertion of prosthetic groups into complex molybdo-enzymes (molybdo-iron-flavo enzymes)
(Applicant
Schwarz, Günter
)
Struktur-Funktions-Beziehung von Cnx1 und Gephyrin bei der Bildung von Proteinclustern in pflanzlichen und tierischen Zellen
(Applicant
Schwarz, Günter
)
Major Research Instrumentation
Completed projects
Automatisiertes Multiplex-Live-Cell-Imaging-System
Cryo electron microscope setup
Isothermes Titrationskalorimeter
Röntgendiffraktionsmessplatz
Röntgendiffraktometer für makromolekulare Kristallographie
Research Fellowships
Completed projects
Structural and functional studies of repulsive guidance molecule (RGM) and its receptor neogenin
(Applicant
Gebauer, Jan
)
Research Training Groups
Current projects
GRK 2550: Dynamic regulation of cellular protein localization
(Spokesperson
Riemer, Jan
)
Completed projects
GRK 192: Scientific Computing - Computer Simulation, Optimization, Multigrid Methods, Parallel Computing
(Spokesperson
Speckenmeyer, Ewald
)
GRK 238: Mechanisms of Damage in CNS Disease - Application of Imaging Techniques
(Spokesperson
Heinemann, Uwe
)
GRK 306: Molecular Analysis of Developmental Processes
(Spokesperson
Flügge, Ulf-Ingo
)
Clusters of Excellence
Completed projects
EXC 229: Cellular Stress Responses in Aging-Associated Diseases
(Spokesperson
Brüning, Jens Claus
)
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