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Institution
Universität Münster
Institut für Biochemie
Address
Corrensstraße 36
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Research Grants
Current projects
Biochemical and structural analysis of unusual docking domains in non-ribosomal peptide synthetases (NRPS)
(Applicant
Mootz, Henning D.
)
Development of high-performing, cysteine-less split inteins as versatile tools for new protein engineering applications
(Applicant
Mootz, Henning D.
)
Mechanism of the RalGAP tumor suppressor complex
(Applicant
Kümmel, Daniel
)
Molecular Analysis of the TSC Complex
(Applicants
Kümmel, Daniel
;
Oeckinghaus, Andrea
)
Regulation of the Rab7 guanine nucleotide exchange factor in endolysosomal biogenesis
(Applicants
Kümmel, Daniel
;
Langemeyer, Lars
;
Ungermann, Christian
)
Completed projects
Analyse der Zellzyklusfunktion des B-myb Gens
(Applicant
Klempnauer, Karl-Heinz
)
Analysis of a novel mechanism for the post-transcriptional regulation of protein kinase Hipk2 expression
(Applicant
Klempnauer, Karl-Heinz
)
Analysis of the "de novo" chromatin opening induced by C/EBPß
(Applicant
Klempnauer, Karl-Heinz
)
Characterization of target RNAs of the tumor suppressor protein Pdcd4
(Applicants
Klempnauer, Karl-Heinz
;
Leidel, Sebastian
)
Characterizaton of the chromatin remodelling activity of the transcription factor c-Myb
(Applicant
Klempnauer, Karl-Heinz
)
Charakterisierung der Zielgene des Transkriptionsfaktors c-Myb
(Applicant
Klempnauer, Karl-Heinz
)
Development and optimization of photo-switchable inteins for the control of antibodies by light
(Applicant
Mootz, Henning D.
)
Entwicklung neuer bioanalytischer Nachweisverfahren auf der Basis von Zellen, Proteinen und Membranen
(Applicant
Galla, Hans Joachim
)
Investigation of novel interaction partners of the transcription factor B-Myb and the role of B-Myb in the DNA-damage response
(Applicant
Klempnauer, Karl-Heinz
)
Mechanistic Studies and Directed Protein Evolution of a Semi-synthetic Intein
(Applicant
Mootz, Henning D.
)
Nonribosomal peptide synthetases (NRPSs): Understanding functional domain interplay and biosynthetic directionality using FRET spectroscopy
(Applicant
Mootz, Henning D.
)
Phosphorylation of the transcription factor C/EBPß and the coactivator p300
(Applicant
Klempnauer, Karl-Heinz
)
Regulation der Aktivität des Transkriptionsfaktors C/EBPbeta durch nukleäre Effektoren
(Applicant
Klempnauer, Karl-Heinz
)
Untersuchungen zur Rolle des Tumorsuppressors Pdcd4 bei der zellulären Antwort auf DNA-Schädigung
(Applicant
Klempnauer, Karl-Heinz
)
Independent Junior Research Groups
Completed projects
Chemical modification of proteins in vivo and generation of switchable proteins by new approaches in semi-synthetic protein chemistry
(Applicant
Mootz, Henning D.
)
Strukturelle und funktionelle Untersuchungen von Interaktionspartnern aktivierter Ral GTPasen
(Applicant
Kümmel, Daniel
)
Research Units
Completed projects
Präparation semi-synthetischer Proteine durch ein neuartiges trans-spleißendes Intein
(Applicant
Mootz, Henning D.
)
Priority Programmes
Completed projects
Biological Influence of Nanoparticles on Exposed Epithelial Respiratory Surfaces - BIONEERS
(Applicants
Galla, Hans Joachim
;
Kirkpatrick, Ph.D., Charles James
;
Maskos, Michael
;
Stauber, Roland H.
)
New approaches for the site-selective chemical modification of therapeutic proteins under mild conditions
(Applicant
Mootz, Henning D.
)
Collaborative Research Centres
Current projects
Adaptation of a Rab/GEF module for initiation and maintenance of planar cell polarity and cilia
(Project Head
Kümmel, Daniel
)
Cell-type and activation-specific labelling of different leukocyte populations in vivo by bioorthogonal tagging
(Project Heads
Mootz, Henning D.
;
Rentmeister, Andrea
)
Integrated Research Training Group (IRTG)
(Project Heads
Beeken, Marco
;
Gonzalez Montoro, Ayelen
;
Kümmel, Daniel
;
Paululat, Achim
)
Completed projects
Cooperativity of Membrane Lipid Domain Organization Mediated by Peripherally Associated Proteins: Principles and Visualization
(Project Heads
Galla, Hans Joachim
;
Gerke, Volker
;
Glorius, Frank
;
Heuer, Andreas
)
Die Blut-Hirn-Schranke in vitro: Regulation der Permeabilität und Migration von immunkometenten Zellen
(Project Head
Galla, Hans Joachim
)
Einfluß der extrazellulären Matrix auf die Differenzierung des Endothels und des Epithels der Blut-Hirn-Schranken
(Project Head
Galla, Hans Joachim
)
Establishment of endosomal membrane domains by guanine nucleotide exchange factors
(Project Head
Kümmel, Daniel
)
Functional Regulation of ABC Transporters of the Multi-Drug- Resistance by Cooperative Interactions
(Project Heads
Galla, Hans Joachim
;
Studer, Armido
)
Interaktion von myb- und C/EBP-Transkriptionsfaktoren in der Proliferation und Differenzierung haematopoetischer Zellen
(Project Head
Klempnauer, Karl-Heinz
)
Modellsysteme des Lungensurfactants
(Project Head
Galla, Hans Joachim
)
Modellsysteme des Lungensurfactants: Die funktionelle Bedeutund der Lipidkomponenten und der Surfactantproteine B und C
(Project Head
Galla, Hans Joachim
)
Molekulare Organisation als Funktionskriterium in Lipid- und Protein-Assoziaten
(Project Head
Galla, Hans Joachim
)
Molekulare Organisation als Funktionskriterium in organisierten Lipidmono- und Multischichtsystemen
(Project Head
Galla, Hans Joachim
)
New Protein Chemical Tools for the Analysis of Cooperative Effects within Protein Interactions mediated by Ubiquitin-like Modifiers
(Project Head
Mootz, Henning D.
)
Regulatorische DNA Elemente als Werkzeuge zum Studium der Makrophagen- und Granulozytendifferenzierung
(Project Head
Klempnauer, Karl-Heinz
)
Research Fellowships
Completed projects
Gene Regulation by Decapping and Cap Methylation of Mammalian mRNAs
(Applicant
Mattay, Johanna
)
Structural Studies on the Exocyst Tethering Complex
(Applicant
Kümmel, Daniel
)
Major Research Instrumentation
Completed projects
AFM Rasterkraftmikroskop
Automated storage and documentation system for protein crystallography ("crystal hotel")
Fluorescence-activated Cell Sorter (FACS)
Konfokales inverses Laser-Scanning Mikroskop
LC-gekoppeltes ESI-Q-TOF-Massenspektrometer
Research Training Groups
Completed projects
GRK 1409: Molecular Interactions of Pathogens with Biotic and Abiotic Surfaces
(Spokesperson
Schmidt, Marcus Alexander
)
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