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Institution
Universitätsklinikum Ulm
Zentrum für Innere Medizin
Klinik für Innere Medizin III
Address
Albert-Einstein-Allee 23
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Clinical Research Units
Completed projects
Core facility for molecular cytogenetics, genetic diagnostics and profiling
(Applicants
Bullinger, Lars
;
Langer, Christian
)
Inhibitor of Apoptosis Proteins (IAPs) als pathogenetisch relevante therapeutische Zielstruktur bei der chronischen lymphatischen Leukämie (CLL)
(Applicant
Stilgenbauer, Stephan
)
Radioaktive Arzneimittel zur Diagnostik und Therapie
(Applicant
Neumaier, Bernd
)
Radioimmuntherapie refraktärer akuter myeloischer Leukämien
(Applicant
Bunjes, Donald
)
Research Grants
Current projects
Multi-state modeling for the evaluation of prognostic and predictive biomarkers in acute myeloid leukemia
(Applicants
Benner, Axel
;
Beyersmann, Jan
;
Döhner, Hartmut
)
Transmission ecology and risk factors for cystic echinococcosis in sub-Saharan Africa
(Applicants
Kern, Peter
;
Mackenstedt, Ute
)
Completed projects
Array-basierte SNP-Analyse bei der akuten myeloischen Leukämie des Erwachsenen mit normalem Karyotyp zur Identifizierung genomischer Imbalancen und uniparentaler Disomien
(Applicant
Döhner, Konstanze
)
Cystic echinococcosis in sub-Saharan Africa Research Initiative (Epidemiology and clinical implications of the genetic diversity of Echinococcus spp. in eastern and southern Africa)
(Applicants
Kern, Peter
;
Romig, Thomas
)
Expressionsanalyse von Kandidatengenen bei der chronischen lymphatischen Leukämie (CLL) mittels quantitativer RT-PCR (RQ-PCR)
(Applicant
Stilgenbauer, Stephan
)
Extracellular vesicle RNA as systemic modulators of the tumor microenvironment in B cell lymphoma
(Applicants
Kuchenbauer, Florian
;
Mertens, Daniel
;
Seiffert, Martina
)
FLT3-ITD variants in AML - impact on disease biology and treatment outcome
(Applicants
Bullinger, Lars
;
Fischer, Thomas
)
Funktionelle Analyse rekurrenter Deletionen der chromosomalen Bande 3p14.1-p13 bei der akuten myeloischen Leukämie
(Applicant
Gaidzik, Verena
)
Hochauflösende "Single Nucleotide Polymorphism" (SNP) Microarray-Analyse bei der Chronischen Lymphatischen Leukämie (CLL): Identifizierung neuer Pathomechanismen und prognostischer Subgruppen
(Applicant
Stilgenbauer, Stephan
)
Identification and charakterization of the early developmental factor and homeobox gene VENTX2 in normal and malignant human hematopoiesis
(Applicant
Rawat, Ph.D., Vijay Pal Singh
)
Identifizierung pathogenetisch relevanter Sekundäraberrationen bei der Core Binding Factor Akuten Myeloischen Leukämie mit Hilfe array-basierter SNP-Analysen
(Applicant
Döhner, Konstanze
)
Immunogenität von mutations-spezifischen Peptidsequenzen bei der AML
(Applicant
Greiner, Jochen
)
Modulation of GVH/GVL by cytokines and induction of specific GVL by peptide vaccination in a mouse model
(Applicant
Schmitt, Michael
)
Molekulare und funktionelle Charakterisierung von Kandidatengenen in der Konsensusdeletionsregion 7q22-q31.1 bei myeloischen Leukämien
(Applicant
Döhner, Konstanze
)
Rolle des Rezeptors für Hyaluronsäure-vermittelte Motilität (RHAMM/CD168) bei der Proliferation myeloischer Blasten
(Applicant
Greiner, Jochen
)
Collaborative Research Centres
Completed projects
Central Tasks
(Project Head
Döhner, Hartmut
)
Characterization of the novel 'Human PBX1 Interacting Protein' (HPIP) and its role in normal and malignant hematopoiesis
(Project Head
Feuring-Buske, Michaela
)
Detailed characterization of genomic aberrations in pancreatic cancer and their role in prognosis and therapy
(Project Heads
Holzmann, Karlheinz
;
Schwänen, Carsten
)
Dissecting AML treatment response to FLT3 inhibitors by single-cell sequencin
(Project Heads
Döhner, Konstanze
;
Rippe, Karsten
)
Functional analysis of recurrent deletions of chromosomal band 3p14.1-p13 in acute myeloid leukemia
(Project Head
Gaidzik, Verena
)
Genomic instability, disease evolution and rational treatment development in CLL mouse models
(Project Heads
Jebaraj, Billy
;
Müller, Annika
;
Stilgenbauer, Stephan
)
Hyperthermie-assoziierte Expression von Hitzeschockproteinen, Protoonkogenen und Zytokin-Genen: Signaltransduktionswege und Identifizierung relevanter Transkriptionsfaktoren
(Project Head
Herrmann, Friedhelm
)
Mechanisms of CLL progression and Richter transformation in patients with CLL treated with agents targeting BTK and BCL2
(Project Heads
Döhner, Hartmut
;
Mertens, Daniel
;
Stilgenbauer, Stephan
)
Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation
(Project Heads
Bullinger, Lars
;
Döhner, Konstanze
)
SFB 1074: Experimental Models and Clinical Translation in Leukemia
(Spokesperson
Döhner, Hartmut
)
The role of homeobox genes in erythroid leukemia
(Project Head
Feuring-Buske, Michaela
)
Major Research Instrumentation
Completed projects
Geräteeinheit für die Sequenzierung und Auftrennung genomischer Fragmente sowie für die quantitative PCR-Analyse
Priority Programmes
Completed projects
Genetic and epigenetic search for tumor suppressor genes on chromosome 7q in acute myeloid leukemia
(Applicants
Döhner, Hartmut
;
Plass, Christoph
)
Clinical Trials
Completed projects
Prospective evaluation of residual disease in intensively treated patients with acute myeloid leukemia (AML) as surrogate endpoint for survival
(Applicant
Schlenk, Richard F.
)
Research Fellowships
Completed projects
Characterization of the molecular basis for combined epigenetic treatment and BCL2 inhibition in myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML)
(Applicant
Bohl, Stephan
)
The functional role of PPM1D in clonal hematopoiesis and therapy-related myeloid malignancies and its potential for therapeutic targeting
(Applicant
Agrawal, Mridul
)
Transcriptional and genetic profiling of clonal hematopoiesis at single-cell resolution
(Applicant
Jahn, Nikolaus
)
Research Units
Current projects
FOR 2674: Aging-related epigenetic remodeling in acute myeloid leukemia
(Spokesperson
Lübbert, Michael
)
FOR 5659: TARGET-MPN: TARgetinG disease pErsisTence and progression of MyeloProliferative Neoplasms (MPN)
(Spokesperson
Heidel, Florian
)
Longitudinal comprehensive transcriptome analyses to unravel disease persistence and evolution in MPN
(Applicants
Bullinger, Lars
;
Döhner, Konstanze
)
Completed projects
Genetic Landscape of Acute Myeloid Leukemia (AML) in Older Patients
(Applicants
Bullinger, Lars
;
Döhner, Hartmut
;
Döhner, Konstanze
)
Graduate Schools
Completed projects
GSC 270: International Graduate School in Molecular Medicine Ulm
(Spokesperson
Kühl, Michael
)
Additional Information
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