SFB 1470:  Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies

• Subject Area: Medicine ; Biology ; Computer Science, Systems and Electrical Engineering
• Term: since 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Ventricular cardiomyocyte signal compartmentation and functional reserve in HFpEF (Project Heads Annibale, Paolo ;  Heinzel, Ph.D., Frank ;  Hohendanner, Ph.D., Felix )
• A02 - Lipid-based control of the unfolded protein response in HFpEF (Project Head Schiattarella, Gabriele )
• A03 - Linking metabolism, mechanotransduction and endothelial dysfunction in HFpEF (Project Heads Gerhardt, Holger ;  Landmesser, Ulf )
• A04 - Cardio-pulmonary interaction in HFpEF (Project Heads Grune, Jana ;  Kübler, Wolfgang )
• A05 - Role of sex hormones on microbiome, immunity, and coronary microvascular dysfunction and rarefication in experimental HFpEF (Project Heads Dechend, Ralf ;  Forslund-Startceva, Sofia K. )
• A06 - Immune regulation of vascular rarefaction and diastolic myocardial remodeling (Project Heads Müller, Dominik N. ;  Sawamiphak, Suphansa )
• A07 - Sterile inflammation and innate immunity in HFpEF (Project Head van Linthout, Ph.D., Sophie )
• A08 - Metabolic reprogramming steered by ISGylation in HFpEF (Project Heads Beling, Antje ;  Berndt, Nokolaus )
• A09 - Lipid-mediated mitochondrial dysfunction in HFpEF during obesity (Project Heads Kintscher, Ulrich ;  Sigrist, Stephan J. )
• A10 - Connecting the gut microbiota to the cardiorenal axis in HFpEF (Project Head Wilck, Nicola )
• B01 - Atrial mechanical and secretory function in human HFpEF (Project Heads Falk, Volkmar ;  Hohendanner, Ph.D., Felix ;  Zhang, Kun )
• B02 - Myocardial immune cell activation and fibrosis (Project Heads Alogna, Alessio ;  Tschöpe, Carsten )
• B03 - Hypertension and metabolic stress associated changes in cardiac cell populations (Project Head Hübner, Norbert )
• B04 - A systems and translational approach to titin dynamics in HFpEF (Project Head Gotthardt, Michael )
• B05 - Molecular plasticity of HFpEF (Project Heads Edelmann, Frank ;  Mertins, Philipp ;  Pieske, Burkert )
• B06 - Imaging structure/function relations in HFpEF - from pathomechanism to artificial-intelligence based classification (Project Heads Hennemuth, Anja ;  Kelle, Sebastian )
• B07 - Mechanisms, therapeutics and diagnostic potential of circular RNAs in HFpEF (Project Head Thum, Ph.D., Thomas )
• V - Central Administrative Project (Project Heads Gotthardt, Michael ;  Pieske, Burkert )
• Z01 - Animal models and human Engineered Heart Tissue (Project Heads Alogna, Alessio ;  Gotthardt, Michael ;  Heinzel, Ph.D., Frank ;  Schiattarella, Gabriele )
• Z02 - Multilevel human HFpEF phenotyping (Project Heads Edelmann, Frank ;  Grittner, Ulrike ;  Pieske, Burkert ;  Rauch, Ph.D., Geraldine ;  Tschöpe, Carsten )
• Z03 - Phenomapping and Systems Modelling (Project Heads Eils, Roland ;  Kühne, Titus )

• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Freie Universität Berlin; Humboldt-Universität zu Berlin
• Spokespersons: Professor Dr. Michael Gotthardt, since 11/2022; Professor Dr. Burkert Pieske, until 11/2022