SFB 1755:  CASCAID - Cellular and Systems Control of Autoimmune Disease

• Subject Area: Medicine ; Computer Science, Systems and Electrical Engineering
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550296805

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• TP01 - Long-term remission of autoimmune diseases by B cell directed CD19 CAR-T cell therapy (Project Heads Bozec, Ph.D., Aline ;  Taubmann, Jule )
• TP02 - Resolution of inflammation by B cell directed CAR T cell therapy (Project Heads Müller, Fabian ;  Schett, Georg )
• TP03 - Understanding IVIg triggered checkpoints leading to remission of autoimmune inflammation (Project Head Nimmerjahn, Falk )
• TP04 - Tissue-level determinants of macrophage polarisation and histological healing (Project Heads Blumenthal, David B. ;  Uderhardt, Stefan )
• TP05 - Checkpoints of T cell tissue egress promoting remission in inflammatory bowel disease (Project Heads Voskens, Caroline J. ;  Zundler, Sebastian )
• TP06 - Changes in lymph node stromal cells by B cell depleting therapies in resolution of inflammation (Project Head Raimondo, Maria Gabriella )
• TP07 - Systemic neutrophil imbalances as indicator and mediator of treatment resistance (Project Heads Grieshaber-Bouyer, Ricardo ;  Steffen, Ulrike )
• TP08 - Mechanisms of CD19+ B cell mediated tissue remodelling as checkpoints in autoimmune- fibrosing disorders such as systemic sclerosis (Project Head Bergmann, Christina )
• TP09 - Characterisation of molecular resistance mechanisms against biological therapies in inflammatory bowel diseases (Project Head Atreya, Raja )
• TP10 - Mechanisms of how acetylated proteins contribute to rheumatoid arthritis progression and relapse (Project Head Zaiss, Mario M. )
• TP11 - Unravelling the role of ACOD1 in gut microbiota-driven relapse mechanisms of rheumatoid arthritis (Project Heads Bozec, Ph.D., Aline ;  Günther, Claudia )
• TP12 - Functional role of TNF- and TNFR-superfamily members in treatment-refractory inflammatory bowel diseases (Project Heads Neurath, Markus F. ;  Weigmann, Benno )
• TP13 - The role of T cell responses in the persistence of systemic inflammation and treatment failure in inflammatory bowel disease (Project Heads Nganou Makamdop, Christiane Krystelle ;  Schober, Kilian )
• TP14 - Impact of a natural microbiota on gut inflammation and therapy response in IBD (Project Heads Becker, Christoph ;  Rosshart, Stephan Patrick )
• TP15 - Fibroblast signatures associated with relapse of arthritis (Project Heads Ramming, Andreas ;  Rauber, Simon )
• WIKO - IMMUNOVERSE: Designing and evaluating a metaversal playground for science communication (Project Heads Jeleazcov, Sandra ;  Morschheuser, Benedikt )
• Z01 - Integrative tissue profiling, omics data analysis support, and FAIR data management (Project Heads Blumenthal, David B. ;  Gupta, Pooja ;  Uderhardt, Stefan )
• Z02 - Central tasks of the CRC1755 CASCAID (Project Head Schett, Georg )

• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Participating University: Otto-Friedrich-Universität Bamberg
• Spokesperson: Professor Dr. Georg Schett