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- Newly published projects in November 2023
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Applicant Dietwald Gruehn
Subject Area Urbanism, Spatial Planning, Transportation and Infrastructure Planning, Landscape Planning
DFG Programme Research Grants Term Since 2023
Research about sound in urban environments is dominated by measurements of sound pressure levels and the reduction of impacts
of the physical and psychological
Temporally and spatially resolved operando characterization of hydrogenolysis in wax-filled Fischer-Tropsch pellets using magnetic resonance imaging.
Applicant Jorg Thöming
Subject Area Chemical and Thermal Process Engineering
DFG Programme Research Grants Term Since 2023
A transient Fischer-Tropsch synthesis (FTS) can lead to an increase in activity and selectivity with respect to desired liquid
products when pure or dilute ...
Applicant Arne Schulz
Subject Area Operations Management and Computer Science for Business Administration
DFG Programme Research Grants Term Since 2023
The project's aim is to develop a decision support system for ridepooling services. Ridepooling services have launched and
are currently launching, especially ...
Applicant Regine von Klitzing
Subject Area Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
Subproject of FOR 5584
DFG Programme Research Units Term Since 2023
In agreement with the overarching goal of the Research Unit TRANSIEVES we will design a light-controlled transient sieve for
particles. Light-controlled ...
Early identification and phenotyping of prodromal dementia with Lewy bodies via established and novel biomarkers: PRO-DLB
Applicant Niels Hansen
Subject Area Biological Psychiatry
DFG Programme Research Grants Term Since 2023
Prodromal dementia with Lewy bodies (DLB) is difficult to diagnose, as it differs in how it is differentiated from psychiatric
disorders or mild cognitive ...
Leader Joachim Knoch
Review Board Electrical Engineering and Information Technology
DFG Programme Major Research Instrumentation Term in 2023
Electron beam lithography is the most flexible, most versatile, high performance lithography technique for the realization
of nanostructures down to the sub-10
Project Head Katharina Kormann
Subject Area Optics, Quantum Optics and Physics of Atoms, Molecules and Plasmas
Subproject of SFB 1491
DFG Programme Collaborative Research Centres Term Since 2023
The objective is to design a simulation tool that cleverly combines fluid and kinetic algorithms in such a way that the full
physics of reconnection processes ...
Multi Hardener Laminates (MHL) – Development of a material concept for reducing temperature gradients in thick-walled components
Applicant Dieter Meiners
Subject Area Plastics Engineering
DFG Programme Research Grants Term Since 2023
In the manufacture of thick-walled fiber composite parts, heat is generated during the exothermic curing reaction of the duromer
resin system. If this is not ...
Applicants Dieter Krause , Sven Matthiesen
Subject Area Engineering Design, Machine Elements, Product Development
DFG Programme Research Grants Term Since 2023
When validating technical systems in dynamic tests, the coupling of the technical system to the test environment can influence
the test results. This influence
Exploring the potential of engineered enzyme families for selective N-alkylation of heteroarenes: A convergent synthesis approach with SAM analogs as intermediates
Applicant Stephan C. Hammer
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
The selective N-alkylation of heteroarenes could drastically shortcut synthesis of complex molecules, especially if two larger
fragments could be coupled by ...
Integration of sequence and reaction data for the design and engineering of methionine adenosyltransferases and other SAM–dependent enzymes
Applicants Jennifer Andexer , Jürgen Pleiss
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
In this project P8, an integrated computational platform for analysing data on sequence, structure, and function of enzymes
will be developed and applied to ...
Applicant Florian Seebeck
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
Linear polyamines such as putrescine, cadaverine, spermidines and spermine consist of the C3, C4 and C5 units derived from
methionine, ornithine and lysine. In
Characterisation and engineering of the cobalamin-dependent Radical SAM methyltransferase Orf29 for the synthesis of novel SAM derivatives
Applicant Gunhild Monika Layer
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
The unusual, cyclopropane-containing amino acid (1S,2S)-2-methyl-1-aminocyclopropane-1-carboxylic acid ((1S,2S)-MeACC) is
biosynthesised in a two-step ...
Applicant Matthias Boll
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
The bacterial degradation of endocrine disrupting and carcinogenic estrogens is essential for their elimination from the environment.
In estrogen-degrading ...
Applicant Andrea Rentmeister
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
Methionine adenosyltransferases (MATs) produce S-adenosyl-L-methionine (SAM) from methionine and ATP. SAM serves as a cosubstrate
for most methyltransferases ...
Applicant Wulf Blankenfeldt
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
Azetidine-1-carboxylic acid (AZE) is a non-canonical ⍺-amino acid found as a building block of several microbial secondary
metabolites with interesting ...
Biosynthesis and utilisation of SAM diastereomers as tools for the characterisation of SAM-dependent enzymes and product diversification
Applicant Jennifer Andexer
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
(S,S)-S-adenosylmethionine (SAM) contains six stereocentres, four of those are fixed through the ribose configuration of the
adenosine moiety. Another ...
Applicant Jennifer Andexer
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
The sustainable and environmentally friendly production of building blocks for fine chemicals, pharmaceuticals, and bulk chemicals
is an urgent and important ...
Applicant Michael Müller
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
In this project, asymmetric de-aromatization by SAM-dependent methylation will be investigated. Our goal is to capture the
transient keto intermediate in the ...
Applicant Lena Barra
Subject Area Biological and Biomimetic Chemistry
Subproject of FOR 5596
DFG Programme Research Units Term Since 2023
S-adenosylmethionine (SAM)-utilizing pyridoxal phosphate (PLP)-dependent enzymes (SAM-PLP enzymes) are an emerging family
of biocatalysts that stand out in ...
Applicant Matthias Eschrig
Subject Area Theoretical Condensed Matter Physics
DFG Programme Research Grants Term Since 2023
Superconducting spintronics combines superconducting quantum coherence and lossless transport with spin selectivity and spin
magnetism. In contrast to ...
Applicant Till Hauser
Subject Area Mathematics
DFG Programme WBP Fellowship Term Since 2023
The aim of the project is to extend the theory of group actions. For this the important concept of mean-equicontinuity will
be studied in the context of ...
Applicants Anne Ebeling , Nico Eisenhauer , Anna Heintz-Buschart , Holger Schielzeth
Subject Area Ecology and Biodiversity of Plants and Ecosystems
Subproject of FOR 5000
DFG Programme Research Units Term Since 2023
After 20 years, the Jena Experiment has accumulated unique datasets of several controlled experiments based on multi-disciplinary
research programs, covering ...
Applicants Meritxell Huch , Anna Taubenberger
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
The complex environment in which tumors arise is characterized by altered mechanical properties compared to healthy tissues.
These mechanical alterations are ...
Interplay of mechanical properties of tissue microenvironment, oncogenic signaling, and metabolism in hepatopancreatic cancer
Applicants Nikolaus Berndt , Christine Sers
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
Oncogenic signaling pathways are the main drivers of cellular transformation and metabolic alterations and lead to cancer
cell invasion and metastasis. ...
Cancer cell unjamming and jamming as prerequisite for the formation of primary and metastatic tumors
Applicants Josef Alfons Käs , Igor Maximilian Sauer
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
Pathological changes such as dysplasia or neoplasia cause morphological changes that induce unjamming as an early motility
transition to collectively ...
Applicants Angelika Eggert , Anja Heeren-Hagemann
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
Neuroblastoma is a difficult-to-treat malignant childhood cancer that originates in the sympathetic nervous system. High-risk
tumors with unfavorable prognosis
Role of tissue mechanical and metabolic properties in cancer formation studied in a translational liver tumor model
Applicants Jing Guo , Lynn Jeanette Savic
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. As most HCC manifests in
cirrhotic livers with heterogenous ...
Applicants Jing Guo , Karl Herbert Hillebrandt
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
The importance of the mechanical traits of the extracellular matrix (ECM) and their influence on the progression of hepatic
and pancreatic tumors is ...
C01 Multiscale mechanical properties of tumors and tumor environment – from tissue specimens to patients
Applicants Stephan Marticorena Garcia , Igor Maximilian Sauer
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
More than 80% of hepatocellular carcinomas (HCC) are found in fibrotic or cirrhotic livers, suggesting that liver fibrosis
creates a premalignant environment ...
Applicants Rolf Otto Reiter , Ingolf Sack
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
There is growing evidence that soft tissue alterations in favor of solid tumor formation are often associated with abnormal
viscosity and tissue fluidity ...
Applicants Jing Guo , Ingolf Sack
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
The mechanical traits of cancer include abnormally high solid stress as well as drastic and spatially heterogeneous changes
in intrinsic mechanical tissue ...
Applicant Ingolf Sack
Subject Area Medical Physics, Biomedical Technology
Subproject of FOR 5628
DFG Programme Research Units Term Since 2023
The mechanical niche of cancer emerges from the collective behavior of cells, which is guided by their physical interactions
with extracellular matrix, stromal
Applicant Albert Jeltsch
Subject Area Biochemistry
DFG Programme Research Grants Term Since 2023
Lysine methylation (Kme) is a widespread post-translational protein modification, which is introduced by protein lysine methyltransferases
(PKMTs). It ...
Applicant Wolfgang Schröder
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
The flow field of screw compressors is characterized by a large range of fluid dynamic scales. Therefore, the numerical analyses
are based on simplifications ...
Novel experimental imaging framework for laser-optical two-phase flow analysis across thin annular rotor-stator gaps
Applicant Jochen Kriegseis
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
The operation of oil-injected rotary-type positive displacement compressors (RPDC) like screw compressors is accompanied with
the formation of a complex ...
Experimental investigation of viscosity, interfacial tension, and thermal conductivity of oil-refrigerant mixtures by light scattering and conventional techniques
Applicant Andreas Paul Fröba
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
The efficiency of oil-injected rotary positive displacement compressors depends strongly on the inevitable two-phase surge
and gap flow in the wall region, ...
Applicant Andreas Jäger ( in cooperation with Ian H. Bell )
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
Oil-injected rotary type positive displacement compressors are mainly used for the compression of refrigerants in various
refrigeration applications. The ...
Applicant Markus Richter ( in cooperation with Paul Stanwix, Eric May )
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
Oil-injected rotary type positive displacement compressors are broadly used for the compression of refrigerants in HVAC (Heating,
Ventilation and Air ...
Investigating the role of the kinesin motor protein Kif21b in regulating BDNF-TrkB signaling and Tau phosphorylation in Alzheimer`s disease conditions
Applicant Matthias Kneussel
Subject Area Experimental Models for the Understanding of Nervous System Diseases
DFG Programme Research Grants Term Since 2023
Alzheimer’s disease (AD) is characterized by both the extracellular accumulation of senile plaques composed of amyloid beta
(Aß) and the intracellular ...
Applicant Anne-Kathrin Classen
Subject Area Cell Biology
DFG Programme Research Grants Term Since 2023
Tissue-intrinsic tumor suppression and defense mechanisms, such as cell-cell competition, are crucial for maintaining tissue
and organismal health. However, ...
Applicant Marcel Griesemer
Subject Area Mathematics
DFG Programme Research Grants Term Since 2023
This project addresses mathematical challenges from non-relativistic quantum electrodynamics (QED) of atoms (and molecules).
Our investigations focus on the ...
Development of models for the calculation of viscosity and thermal conductivity of oil-refrigerant mixtures
Applicant Monika Thol ( in cooperation with Ian H. Bell, Eric Lemmon )
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
Oil-injected rotary displacement compressors are mainly used for the compression of refrigerants in heating, ventilation and
air conditioning systems. The ...
Measuring and modeling of two-phase gap flow for oil-refrigerant mixtures in rotary positive displacement machines
Applicant Andreas Brümmer
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
Oil-injected rotary positive displacement (RPDC) compressors such as twin-screw machines are widely used to compress refrigerants
in HVAC (heating, ...
Applicant Markus Richter
Subject Area Technical Thermodynamics
Subproject of FOR 5595
DFG Programme Research Units Term Since 2023
The main objective of the Research Unit FOR 5595 is to develop a valid calculation model for multiphase surge and gap flows
for oil-refrigerant mixtures in ...
Applicant Yvonne Oelmann
Subject Area Ecology and Biodiversity of Plants and Ecosystems
Subproject of FOR 5000
DFG Programme Research Units Term Since 2023
With ongoing climate change, the frequency of extreme events is increasing. Extreme events such as floods or droughts affect
the availability of water and, ...
Involvement of heparan sulfate and the proteoglycan Syndecan-1 in iron homeostasis of human induced pluripotent stem cells and derived hepatocytes
Applicant Charlotte Rossdam
Subject Area Cell Biology
DFG Programme WBP Fellowship Term Since 2023
In the proposed project we will analyze the role of glycans that commonly decorate the outside of the cellular membrane in
iron homeostasis. Iron homeostasis ...
Metal dusting of Ni-Cu alloys: Dependence of high-temperature attack on crystal orientation and small amounts of thermodynamically stable oxide formers
Applicant Anke Silvia Ulrich
Subject Area Thermodynamics and Kinetics as well as Properties of Phases and Microstructure of Materials
DFG Programme Research Grants Term Since 2023
In order to further increase the efficiency of high-temperature processes, the conditions are becoming more and more aggressive,
which places ever higher ...
Applicants Ulrich Brose , Stefan Scheu
Subject Area Ecology and Biodiversity of Animals and Ecosystems, Organismic Interactions
Subproject of FOR 5000
DFG Programme Research Units Term Since 2023
SP11 addresses the quantitative structure and stability of soil food webs along the plant diversity gradients of the Main
Experiment and the ResCUE Experiment ...
Applicant Christiane Roscher
Subject Area Ecology and Biodiversity of Plants and Ecosystems
Subproject of FOR 5000
DFG Programme Research Units Term Since 2023
Plant tissue nutrient concentrations and ratios are important predictors of ecosystem processes and ecological interactions.
The overall objective of this ...