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Institution

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Universitätsklinikum Freiburg
Centrum für Chronische Immundefizienz

Address Breisacher Straße 115
79106 Freiburg
Deutschland

GERiT This institution in GERiT

79106 Freiburg

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Independent Junior Research Groups
- Completed projects
  - Der molekulargenetische Defekt des Hyper-IgE-Syndroms
    (Applicant Grimbacher, Bodo )
Clinical Research Units
- Completed projects
  - Genetik der kongenitalen Neutropenie
    (Applicant Grimbacher, Bodo )
Priority Programmes
- Completed projects
  - Exit of Mycobacterium avium from granuloma macrophages
    (Applicant Henneke, Philipp )
  - Sphingosine-1-Phosphate Receptors in Human B Cells: Expression, Role and Signaling
    (Applicant Eibel, Hermann )
Collaborative Research Centres
- Current projects
  - Central Tasks
    (Project Head Ehl, Stephan )
  - Genetic defects impairing lymphocyte cytotoxicity: causes and consequences
    (Project Heads Aichele, Peter ; Ehl, Stephan )
  - Lymphoproliferative disease resulting from impaired deletion of FAS controlled T cells.
    (Project Heads Maccari, Maria Elena ; Rensing-Ehl, Anne Katharina )
  - Macrophage dysregulation as cause of chronic inflammation in NADPH oxidase deficiency
    (Project Head Henneke, Philipp )
  - Modular assembly of the autophagy machinery in mitophagy and immunity
    (Project Heads Gámez-Díaz, Laura ; Kraft, Claudine )
  - SFB 1160: Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
    (Spokesperson Ehl, Stephan )
  - Studying the intestinal microbiome as a driver for immune pathology in CTLA4-insufficient individuals and mice
    (Project Head Grimbacher, Bodo )
- Completed projects
  - A preclinical therapeutic gene editing protocol to restore cytotoxic T cell function in acute haemophagocytic lymphohistiocytosis
    (Project Heads Aichele, Peter ; Cathomen, Toni ; Ehl, Stephan )
  - Central Tasks
    (Project Head Ehl, Stephan )
  - Impaired T cell cross-talk in infection-associated immunopathology
    (Project Head Rohr, Jan )
  - Inflammatory signal induction and termination in chronic granulomatous
    (Project Head Henneke, Philipp )
  - Kopplungsanalysen beim familiären variablen Immundefekt (CVID) und selektiven IgA-Defekt - ein Weg zur Identifizierung der genetischen Defekte
    (Project Head Grimbacher, Bodo )
  - Regulation der B Lymphotyten Selektion durch Transkriptionsfaktoren der Early Growth Response (Egr) Genfamilie
    (Project Head Eibel, Hermann )
  - The impact of viral infections on the immunological and clinical phenotype of "leaky" SCID mice
    (Project Head Ehl, Stephan )
  - The role of the CD4 T cell compartment in modulating HLH progression
    (Project Head Aichele, Peter )
  - Tipping the balance: Immune-mediated pathologies in CVID enteropathy
    (Project Heads Grimbacher, Bodo ; Warnatz, Klaus )
CRC/Transregios
- Current projects
  - Central administration and coordination
    (Project Head Henneke, Philipp )
  - Effects of neonatal wildling microbiota on the immune response to vaccination
    (Project Heads Proietti, Ph.D., Michele ; Rosshart, Stephan Patrick )
  - Impact of neonatal CMV infection on lung macrophage development
    (Project Heads Henneke, Philipp ; Ruzsics, Zsolt )
  - Macrophage programming in cytomegalovirus encephalitis
    (Project Head Henneke, Philipp )
  - Perinatal crosstalk of microbiota and intestinal macrophages in the control of mucosal pathogens
    (Project Heads Clavel, Thomas ; Erny, Daniel ; Henneke, Philipp )
  - TRR 359: Perinatal Development of Immune Cell Topology
    (Spokesperson Henneke, Philipp )
- Completed projects
  - BAFF-receptor function in B cell survival and immune responses
    (Project Head Eibel, Hermann )
Major Research Instrumentation
- Completed projects
  - Multi-Application Cell Sorter
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2155: RESIST - Resolving Infection Susceptibility
    (Spokespersons Förster, Reinhold ; Hansen, Gesine ; Schulz, Thomas )

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