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Institution
Universität zu Lübeck
Institut für Neurogenetik
Address
Ratzeburger Allee 160
23562 Lübeck
Deutschland
GERiT
This institution in GERiT
23562 Lübeck
Projects
Research Grants
Current projects
Clinician Scientist School Lübeck: Connecting Brain, Metabolism, and Inflammation (BMI) – Mechanisms and Disease Expression
(Applicant
Sadik, Christian David
)
Complement as driver of neuroinflammation and -degeneration in Parkinson‘s disease
(Applicants
Köhl, Jörg
;
Seibler, Philip
)
Identification of pathogenic structural variants and repeat expansions in Parkinson's disease
(Applicants
Busch, Hauke
;
Lohmann, Katja
;
Trinh, Ph.D., Joanne
)
Investigating the impact of COVID-19 on Parkinson's disease
(Applicants
Glatzel, Markus
;
Klein, Christine
;
Trinh, Ph.D., Joanne
)
Somatische Modifikatoren des erblichen Parkinsonismus
(Applicant
Trinh, Ph.D., Joanne
)
Uncovering novel causes and modifiers of amyotrophic lateral sclerosis by nuclear and mitochondrial genome sequencing
(Applicants
Großkreutz, Julian
;
Klein, Christine
;
Spielmann, Malte
;
Weishaupt, Jochen
;
Westenberger, Ana
)
Completed projects
Elucidating novel genetic causes of dystonia by large-scale sequencing
(Applicants
Busch, Hauke
;
Klein, Christine
;
Lohmann, Katja
)
Epidemiologie nicht-motorischer Symptome beim Parkinsonsyndrom: Häufigkeit, Charakteristika, Spezifität und Verlauf
(Applicants
Kasten, Meike
;
Katalinic, Alexander
)
Genetic modifiers of disease expression in X-linked dystonia-parkinsonism
(Applicants
Bertram, Lars
;
Westenberger, Ana
)
Genetic risk factors of musician´s dystonia
(Applicants
Lohmann, Katja
;
Ziegler, Andreas
)
Identification of novel dystonia genes in consanguineous families
(Applicant
Lohmann, Katja
)
Identification of targets and interactors of the DYT6-related trancription factor THAP1
(Applicant
Lohmann, Katja
)
Identifizierung genetischer Ursachen des "Restless legs"-Syndroms
(Applicants
Lohmann, Katja
;
Stephani, Ulrich
)
Molecular characterization of TUBB4 mutations
(Applicants
Klein, Christine
;
Rakovic, Aleksandar
)
Molekulargenetische und proteinbiochemische Untersuchungen zur Ätiologie des Parkinson-Syndroms mit frühem Beginn
(Applicant
Klein, Christine
)
Role of the PRKRA-(DYT16) gene in different forms of dystonia
(Applicant
Klein, Christine
)
The role of endogenous PINK1 and Parkin mutations in human dopaminergic neurons
(Applicant
Klein, Christine
)
The Role of Short Tandem Repeats in Alzheimer's Disease
(Applicants
Bertram, Lars
;
Dobricic, Valerija
)
Heisenberg Fellowships
Completed projects
Neurologie
(Applicant
Klein, Christine
)
Research Units
Current projects
Coordination Funds
(Applicant
Klein, Christine
)
Data base, phenotyping and prodromal signs, patient involvement and Ethical, Legal and Social Implications (ELSI) aspects, mutational analysis and induced Pluripotent Stem Cell (iPSC) Core
(Applicants
Berg, Daniela
;
Brüggemann, Norbert
;
Lohmann, Katja
;
Seibler, Philip
)
FOR 2488: Reduced penetrance in hereditary movement disorders: Elucidating mechanisms of endogenous disease protection
(Spokesperson
Klein, Christine
)
Identifying Parkinson’s disease penetrance-modifying factors in the population-based Cooperative Health Research in South Tyrol (CHRIS) cohort
(Applicant
Klein, Christine
)
Mechanisms of penetrance and expressivity in X-linked dystonia-parkinsonism
(Applicants
Kaiser, Frank
;
Rakovic, Aleksandar
;
Westenberger, Ana
)
Modifiers of Parkin and PINK1 mutation penetrance in Parkinson’s disease: Endogenous human models
(Applicant
Rakovic, Aleksandar
)
Modifiers of penetrance and expressivity in monogenic dystonia: Insights from systems biology
(Applicants
Busch, Hauke
;
Lohmann, Katja
)
Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease
(Applicants
Grünewald, Anne
;
Kasten, Meike
;
Trinh, Ph.D., Joanne
)
Physiological relevance of genetic risk variants in reduced penetrance
(Applicants
Kaiser, Frank
;
Spielmann, Malte
;
Westenberger, Ana
)
Reduced penetrance in Parkin and PINK1 deficiency: Inflammation as a Parkinson’s disease penetrance modifier
(Applicants
Klein, Christine
;
Seibler, Philip
)
Research Fellowships
Completed projects
Impact of mutant VPS35 on human dopaminergic neurons
(Applicant
Seibler, Philip
)
Parkin-mediated ubiquitination and Parkinson's disease: Role of ubiquitin-conjugating enzymes (E2s) and ubiquitin-interacting motif (UIM)-containing proteins
(Applicant
Westenberger, Ana
)
Collaborative Research Centres
Completed projects
Characterization of action control networks in genetically determined parkinsonism
(Project Heads
Klein, Christine
;
Münchau, Alexander
)
CRC/Transregios
Completed projects
Generation of a reference cohort with extreme eating behaviour
(Project Heads
Brabant, Georg
;
Brüning, Jens Claus
;
Kasten, Meike
;
Klein, Christine
;
Krämer, Ulrike M.
)
Major Instrumentation Initiatives
Current projects
Confocal Laser Scanning Microscope with Light Sheet Modul for the analysis of neuronal three-dimensional cell cultures and organoids
Graduate Schools
Completed projects
GSC 235: Graduate School for Computing in Medicine and Life Sciences
(Spokesperson
Schweikard, Achim
)
Clusters of Excellence (ExStra)
Current projects
EXC 2167: Precision Medicine in Chronic Inflammation (PMI)
(Spokespersons
Niemann, Stefan
;
Riemekasten, Gabriela
;
Schreiber, Stefan
)
Additional Information
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