TRR 298:  Safety Integrated and Infection Reactive Implants

• Subject Area: Materials Science and Engineering ; Biology ; Chemistry ; Computer Science, Systems and Electrical Engineering ; Mechanical and Industrial Engineering ; Medicine ; Social and Behavioural Sciences
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• A01 - Implant safety through individualisation of revision and regeneration of primary prosthetic components (Project Heads Denkena, Berend ;  Dittrich, Marc-André ;  Ettinger, Max ;  Tücking, Lars-René ;  Wichmann, Marcel )
• A03 - New diagnostic methods to detect loosened hip arthroplasties (Project Heads Behrens, Bernd-Arno ;  Jakubowitz, Eike ;  Zimmermann, Stefan )
• A04 - Demand-oriented design and manufacture of damage-tolerant implant junctions (Project Heads Bergmann, Benjamin ;  Denkena, Berend ;  Hurschler, Christof ;  Krödel-Worbes, Alexander ;  Prasanthan, Vannila ;  Sehmisch, Stephan )
• A05 - Sensory cochlea electrode: Sensory safety through detection of critical processes at the electrode-nerve interface (Project Heads Lenarz, Thomas ;  Maier, Hans Jürgen ;  Prenzler, Nils Kristian )
• A06 - Detection of cell occupation on cochlear implants and implant position for atraumatic insertion and long-term monitoring of stimulation efficiency (Project Heads Kral, Andrej ;  Maier, Ph.D., Hannes ;  Zimmermann, Stefan )
• A07 - Surrogate-modelling for monitoring of implants (Project Heads Aldakheel, Fadi ;  Budde, Stefan ;  Haertlé, Marco ;  Nackenhorst, Udo ;  Nogueira, Waldo )
• A08 - Tissue-conserving hip and knee arthroplasty removal (Project Heads Nürnberger, Florian ;  Windhagen, Henning )
• A09 - Deciphering the role of wear particles in cellular and molecular interactions during aseptic implant loosening in biomimetic 3D in vitro models (Project Heads Hoffmann, Andrea ;  Lee-Thedieck, Cornelia )
• B01 - Autonomous chemical and cell-based sensor-actuator systems for the detection and combat of implant-associated infections (Project Heads Menzel, Henning ;  Stiesch, Meike ;  Wirth, Dagmar )
• B02 - Uncovering of molecular mechanisms involved in biofilm-associated peri-implant infections (Project Heads Häußler, Susanne ;  Li, Yang ;  Stiesch, Meike )
• B03 - Optical sensors for responsive implants (Project Heads Bahnemann, Janina ;  Heisterkamp, Alexander ;  Nikutta, Katharina ;  Scheper, Thomas )
• B04 - Active stimulus-responsive implants (Project Heads Klose, Christian ;  Maier, Hans Jürgen ;  Pott, Philipp-Cornelius ;  Wurz, Marc Christopher )
• B06 - Tracking and localised therapy of inflammation and infections on surfaces of established implants (Project Head Wirth, Dagmar )
• B07 - Simulation of biofilm growth and drug-induced degradation (Project Heads Junker, Philipp ;  Soleimani, Meisam ;  Szafranski, Szymon Piotr ;  Wriggers, Peter )
• B08 - Implant coating facilitating an intentional implant removal (Project Heads Menzel, Henning ;  Polarz, Sebastian ;  Weinhart, Marie )
• B09 - Phototheranostic materials for sustainable and multimodal implant protection (Project Heads Gellrich, Nils-Claudius ;  Korn, Philippe ;  Polarz, Sebastian )
• INF - Research data management for safety-integrated and infection-reactive implants (Project Heads Auer, Sören ;  Karras, Oliver )
• Z01 - Trust and patient-centred communication as determinants of implant acceptance and compliance with advanced implant treatment (Project Heads Baumann, Eva ;  Klimmt, Christoph ;  Link, Ph.D., Elena )
• Z02 - Integrated research training group (IRTG) “Implant Technologies” (Project Heads Melk, Ph.D., Anette ;  Wurz, Marc Christopher )
• Z03 - Central Task (Project Head Stiesch, Meike )

Completed projects

• A02 - Mechanisms of implant failure during aseptic loosening of hip endoprostheses (Project Heads Hoffmann, Andrea ;  Melk, Ph.D., Anette ;  Stukenborg-Colsman, Christina )
• B05 - Autonomous sequential drug release systems (Project Heads Behrens, Peter ;  Gellrich, Nils-Claudius ;  Polarz, Sebastian )

• Applicant Institution: Medizinische Hochschule Hannover
• Co-Applicant Institution: Gottfried Wilhelm Leibniz Universität Hannover
• Participating University: Hochschule für Musik, Theater und Medien Hannover ; Institut für Journalistik und Kommunikationsforschung; Universität Augsburg; Institut für Physik; Johannes Gutenberg-Universität Mainz; Fachbereich Sozialwissenschaften, Medien und Sport; Institut für Publizistik; Technische Universität Braunschweig; Fakultät für Lebenswissenschaften; Institut für Technische Chemie
• Participating Institution: Helmholtz-Zentrum für Infektionsforschung GmbH ; Arbeitsgruppe Modellsysteme für Infektion und Immunität; Technische Informationsbibliothek (TIB)
• Spokesperson: Professorin Dr. Meike Stiesch