Project Details
Projekt
KFO 5002: Deciphering genome dynamics for subtype-specific therapy in pancreatic cancer
Subject Area
Medicine
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 426671079
No abstract available
DFG Programme
Clinical Research Units
Projects
- Biomedical Informatics Support Platform (BISP) - provides IT structures and pipelines to store, exchange and integrate the numerous phenotypic, genomic and functional data generated in SP1-7 and CP1. (Applicants Beißbarth, Tim ; Salinas, Gabriela ; Sax, Ulrich )
- Characterizing inflammatory transcription hubs in ARID1A-deficient PDAC subtypes (Applicant Heßmann, Elisabeth )
- Coordination Funds (Applicant Ellenrieder, Volker )
- Epigenetic regulation and therapeutic targeting of PDAC subtypes with aberrant drug metabolism (Applicant Neesse, Albrecht )
- Exploiting oncogenic transcription factor complexes in misp53 PDAC subtypes (Applicants Schulz-Heddergott, Ph.D., Ramona ; Singh, Shiv )
- Exploiting subtype-specific HSP90 targeting for sensitization of PDAC cells towards platinum-based therapy (Applicant Dobbelstein, Matthias )
- GSK3βhigh subtype-specific DNA repair mechanisms and resistance in PDAC (Applicant Ellenrieder, Volker )
- Metabolic impact on chromatin topology in subpopulation-derived PDAC organoids (Applicants Conradi, Lena-Christin ; Papantonis, Argyris )
- Translational platform for PDAC models and drug response validation (Applicants Dobbelstein, Matthias ; Heßmann, Elisabeth ; Kaulfuß, Silke ; Ströbel, Philipp ; Wollnik, Bernd )
- Understanding TGFβ driven mitotic errors and chromosomal instability in SMAD4-deficient PDAC subtypes (Applicant Bastians, Holger )
Spokesperson
Professor Dr. Volker Ellenrieder
Project Heads
Professor Dr. Holger Bastians; Professor Dr. Tim Beißbarth; Privatdozentin Dr. Lena-Christin Conradi; Professor Dr. Matthias Dobbelstein; Professor Dr. Jochen Gaedcke; Privatdozentin Dr. Silke Kaulfuß; Professor Dr. Albrecht Neesse; Professor Dr. Argyris Papantonis; Dr. Gabriela Salinas; Professor Dr. Ulrich Sax; Privatdozentin Dr. Ramona Schulz-Heddergott, Ph.D.; Dr. Shiv Singh; Professor Dr. Philipp Ströbel; Professor Dr. Bernd Wollnik
