Project Details
Projekt
KFO 5002: Deciphering genome dynamics for subtype-specific therapy in pancreatic cancer
Subject Area
Medicine
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 426671079
No abstract available
DFG Programme
Clinical Research Units
Projects
- Causes and consequences of SMAD4- and TGFβ-regulated PDAC genome instability (Applicant Bastians, Holger )
- Coordination Funds (Applicant Ellenrieder, Volker )
- Coordination Funds (Applicant Heßmann, Elisabeth )
- CP1: Translational platform for PDAC model generation and drug response characterization (Applicants Dobbelstein, Matthias ; Heßmann, Elisabeth ; Kaulfuß, Silke ; Schneider, Günter ; Ströbel, Philipp ; Wollnik, Bernd )
- CP2 Biomedical Informatics Support Platform (BISP) (Applicants Beißbarth, Tim ; Salinas, Gabriela ; Sax, Ulrich )
- Epigenetic regulation and therapeutic targeting of PDAC subtypes with aberrant drug metabolism (Applicant Neesse, Albrecht )
- Exploiting oncogenic transcriptional reprogramming in misp53 PDAC subtypes (Applicants Schulz-Heddergott, Ph.D., Ramona ; Singh, Shiv )
- Exploiting the transcription cycle to tailor rational-based combination therapies for PDAC (Applicant Schneider, Günter )
- Inducing therapeutic vulnerabilities in patient-derived PDAC models by targeting the metabolome-to-3D chromatin axis (Applicants Conradi, Lena-Christin ; Papantonis, Argyris )
- SP1: Exploiting tumor cell-intrinsic and -extrinsic processes for boosting gemcitabine sensitivity in ARID1A-deficient PDAC (Applicant Heßmann, Elisabeth )
- SP4: Exploring resistance mechanisms and therapeutic vulnerabilities in GSK3β;NFATc1high subtype tumors (Applicant Ellenrieder, Volker )
- Synergistic PDAC cell ablation by inhibiting CDKs and histone demethylases (Applicant Dobbelstein, Matthias )
Spokesperson
Professor Dr. Volker Ellenrieder
Project Heads
Professor Dr. Holger Bastians; Professor Dr. Tim Beißbarth; Privatdozentin Dr. Lena-Christin Conradi; Professor Dr. Matthias Dobbelstein; Privatdozentin Dr. Silke Kaulfuß; Professor Dr. Argyris Papantonis; Dr. Gabriela Salinas; Professor Dr. Ulrich Sax; Professor Dr. Günter Schneider; Privatdozentin Ramona Schulz-Heddergott, Ph.D.; Dr. Shiv Singh; Professor Dr. Philipp Ströbel; Professor Dr. Bernd Wollnik
