FOR 5889:  How Death and Danger Signals dynamically control Stage Transitions in Chronic Hepatic Disease (dangerhep)

• Subject Area: Medicine
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 546585894

No abstract available

• DFG Programme: Research Units

Projects

• Coordination Funds (Applicant Lüdde, Ph.D., Tom )
• Defining the autophagy-mediated secretome and its impact during stage transitions in chronic liver disease (Applicant Kondylis, Ph.D., Evangelos )
• Exploring the function of apoptotic effector Caspases in stage transitions of hepatic diseases (Applicant Schneider, Anne Theres )
• Functional dissection of canonical vs. non-canonical NF-κB-dependent danger signals in hepatocellular carcinoma development (Applicant Vucur, Mihael )
• Functional intravital imaging platform (Applicant Ghallab, Ahmed )
• How danger signals control an immunological „point-of-no-return“ in the MASLD-HCC transition (Applicant Heikenwälder, Mathias )
• How release- and effector-mechanisms of DAMPs in sublethal hepatocyte necroptosis control transition points in hepatocarcinogenesis (Applicant Lüdde, Ph.D., Tom )
• Linear ubiquitination in the adipose tissue influences stage transitions in hepatic disease (Applicant Peltzer, Ph.D., Nieves )
• Lipogranuloma formation in steatohepatitis (Applicants Cadenas, Cristina ;  Hengstler, Jan G. )
• Role of stress response kinases in regulating cell death and subsequent release and action of DAMPs in the pathogenesis of MASH (Applicants Angendohr, Carolin ;  Bode, Johannes Georg )
• The role of sphingolipids as DAMPs in stage transitions from MASLD to HCC (Applicant Levkau, Bodo )

• Spokesperson: Professor Dr. Tom Lüdde, Ph.D.