SPP 1085:  Cellular Mechanisms of Alzheimer's Disease

• Subject Area: Medicine
• Term: from 2000 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5469986

No abstract available

• DFG Programme: Priority Programmes
• International Connection: France

Projects

• A reverse genetic approach to define physiologically important functional domains of APP family proteins: analysis in APP/APLP knockout mice (Applicant Müller, Ulrike )
• Alzheimer Amyloid Precursor Protein cleavage regulation by Gangliosides (Applicant Hartmann, Tobias )
• APP, APLPs and BACE: Substrate-enzyme interaction in a high molecular weight complex (Applicant Multhaup, Gerhard )
• APP-Processing (Applicant Merdes, Gunter )
• Cellular function of the amyloid precursor like protein 1 in endocytosis and proteolytic shedding of APP (Applicant Lichtenthaler, Stefan )
• Die Rolle der Proteoglykane im zellulären Metabolismus der ßAmyloid Peptide (Applicant März, Winfried )
• Die Rolle von Sphingolipid-Cholesterin Mikrodomänen (Rafts) beim Transport und Prozessierung des Amyloid-Vorläuferproteins (Applicant Simons, Kai )
• Effects of cholesterol and glia-derived lipoproteins on survival, growth and synaptic differentiation of highly purified neurons from different regions of the mouse brain (Applicant Pfrieger, Frank W. )
• Functional analysis of axonal transport vesicles containing APP, APLP1 or APLP2 (Applicant Kins, Stefan )
• Functional dissection of presenilins in a C. elegans in vivo model (Applicant Baumeister, Ralf )
• Identification and functional characterization of neuroprotective signaling mechanisms and of target genes that mediate the selective resistance of neuronalcells against Alzheimer`s Disease-associated oxidative nerve cell death (Applicant Behl, Christian )
• Interactions and functional analysis of normal and PHF-like mutated tau proteins as a model for tau pathology in Alzheimer`s disease (Applicant Brandt, Roland )
• Metabolismus von APP und Aß im Endoplasmatischen Retikulum: Die mögliche Bedeutung für die Regulation von Apoptose und Antiapoptose bei der Alzheimerschen Erkrankung (Applicant Herzog, Volker )
• Molecular Mechanisms in the Regulation of Metabolism and Biological Functions of the ß-Amyloid Precursor Protein (Applicant Walter, Ph.D., Jochen )
• Molecular Mechanisms of Presenilin Function (Applicant Haass, Christian )
• Molecular mechanisms of secretase inhibition (Applicant Schmidt, Boris )
• PHF-aggregation and microtubule interactions of tau mutants (Applicant Mandelkow, Eckhard )
• Protein-protein and protein-lipid interactions of the ß-amyloid precursor protein during membrane trafic in neurosecretory cells (Applicant Huttner, Wieland B. )
• Regulation of gene expression and activity of the alpha-secretase ADAM 10 (Applicant Fahrenholz, Falk )
• Selective neuronal cell death in Alzheimer`s disease: role of apolipoprotein E4,P/Q type Ca2+-channels and oxidative stress in entorhinal cortex layer II stellate cells (Applicant Grantyn, Rosemarie )
• Steroid Hormone Regulation of Alzheimer ß Amyloid Precursor and Tau Proteins (Applicant Almeida, Osborne )
• Structure, supramolecular association and interaction of patho-active presenilin and betaAPP domains by high resolution mass spectrometry (Applicant Przybylski, Ph.D., Michael )
• Tau and intracellular transport (Applicant Mandelkow, Eva-Maria )
• Tau-Modification and Oxidative Stress (Applicant Grune, Tilman )
• The cellular basis of APP processing: trafficking and assembly of gamma-secretases and its substrates (Applicant Haass, Christian )
• The Role of Phosphorylation in the Regulation of Presenilin Functions (Applicant Walter, Ph.D., Jochen )
• The role of the members of the LDL receptor family in the cellular metabolism of ß amyloid peptides (Applicant März, Winfried )
• To unravel the spatio-temporal profile, function(s) and molecular partners of y-secreatase activity during vertebrate embryogenesis, using the zebrafish as a simple in vivo model system (Applicant Bally-Cuif, Laure )

• Spokespersons: Professor Dr. Christian Haass; Professor Dr. Gerhard Multhaup