Detailseite
Projekt
SPP 1085: Zelluläre Mechanismen der Alzheimer Erkrankung
Fachliche Zuordnung
Medizin
Förderung
Förderung von 2000 bis 2006
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469986
Keine Zusammenfassung vorhanden
DFG-Verfahren
Schwerpunktprogramme
Internationaler Bezug
Frankreich
Projekte
- A reverse genetic approach to define physiologically important functional domains of APP family proteins: analysis in APP/APLP knockout mice (Antragstellerin Müller, Ulrike )
- Alzheimer Amyloid Precursor Protein cleavage regulation by Gangliosides (Antragsteller Hartmann, Tobias )
- APP, APLPs and BACE: Substrate-enzyme interaction in a high molecular weight complex (Antragsteller Multhaup, Gerhard )
- APP-Processing (Antragsteller Merdes, Gunter )
- Approaches for upregulation of the alpha-secretase and elucidation of its role in differentiation and Abeta homeostasis (Antragsteller Fahrenholz, Falk )
- Cellular function of the amyloid precursor like protein 1 in endocytosis and proteolytic shedding of APP (Antragsteller Lichtenthaler, Stefan )
- Die Rolle der Proteoglykane im zellulären Metabolismus der ßAmyloid Peptide (Antragsteller März, Winfried )
- Die Rolle von Sphingolipid-Cholesterin Mikrodomänen (Rafts) beim Transport und Prozessierung des Amyloid-Vorläuferproteins (Antragsteller Simons, Kai )
- Effects of cholesterol and glia-derived lipoproteins on survival, growth and synaptic differentiation of highly purified neurons from different regions of the mouse brain (Antragsteller Pfrieger, Frank W. )
- Functional analysis of axonal transport vesicles containing APP, APLP1 or APLP2 (Antragsteller Kins, Stefan )
- Functional dissection of presenilins in a C. elegans in vivo model (Antragsteller Baumeister, Ralf )
- Identification and functional characterization of neuroprotective signaling mechanisms and of target genes that mediate the selective resistance of neuronalcells against Alzheimer`s Disease-associated oxidative nerve cell death (Antragsteller Behl, Christian )
- Interactions and functional analysis of normal and PHF-like mutated tau proteins as a model for tau pathology in Alzheimer`s disease (Antragsteller Brandt, Roland )
- Metabolismus von APP und Aß im Endoplasmatischen Retikulum: Die mögliche Bedeutung für die Regulation von Apoptose und Antiapoptose bei der Alzheimerschen Erkrankung (Antragsteller Herzog, Volker )
- Molecular Mechanisms in the Regulation of Metabolism and Biological Functions of the ß-Amyloid Precursor Protein (Antragsteller Walter, Ph.D., Jochen )
- Molecular Mechanisms of Presenilin Function (Antragsteller Haass, Christian )
- PHF-aggregation and microtubule interactions of tau mutants (Antragsteller Mandelkow, Eckhard )
- Protease inhibition and imaging of amyloid assemblies (Antragsteller Schmidt, Boris )
- Protein-protein and protein-lipid interactions of the ß-amyloid precursor protein during membrane trafic in neurosecretory cells (Antragsteller Huttner, Wieland B. )
- Selective neuronal cell death in Alzheimer`s disease: role of apolipoprotein E4,P/Q type Ca2+-channels and oxidative stress in entorhinal cortex layer II stellate cells (Antragstellerin Grantyn, Rosemarie )
- Steroid Hormone Regulation of Alzheimer ß Amyloid Precursor and Tau Proteins (Antragsteller Almeida, Osborne )
- Structure, supramolecular association and interaction of patho-active presenilin and betaAPP domains by high resolution mass spectrometry (Antragsteller Przybylski, Ph.D., Michael )
- Tau and intracellular transport (Antragstellerin Mandelkow, Eva-Maria )
- Tau-Modification and Oxidative Stress (Antragsteller Grune, Tilman )
- The cellular basis of APP processing: trafficking and assembly of gamma-secretases and its substrates (Antragsteller Haass, Christian )
- The Role of Phosphorylation in the Regulation of Presenilin Functions (Antragsteller Walter, Ph.D., Jochen )
- The role of the members of the LDL receptor family in the cellular metabolism of ß amyloid peptides (Antragsteller März, Winfried )
- To unravel the spatio-temporal profile, function(s) and molecular partners of y-secreatase activity during vertebrate embryogenesis, using the zebrafish as a simple in vivo model system (Antragstellerin Bally-Cuif, Laure )
