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SFB 854:  Molecular Organisation of Cellular Communications within the Immune System

Subject Area Medicine
Term from 2010 to 2021
Website Homepage
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925
 
The project aims at elucidating the molecular basis of communication processes and networks that regulate immune responses in health and disease. To this end, the individual CRC854 projects assess the molecular mechanisms of immune cell communication at the intercellular and intracellular level as well as with regard to specific organs. State of the art biochemical, genetic and imaging technologies are implemented and developed within the project to achieve the scientific goals. The knowledge and the molecular/genetic toolboxes generated during the 2nd funding period of the Project will provide the basis for the research that the project plans for the 3rd funding period. As before, the research program is divided into two research areas: Projects in Research Area A: "Molecular and cellular communication in inflammation and infection" study the molecular mechanisms of intra- and intercellular communication processes with a focus on organ-specific (brain, liver, kidney, hematopoietic system, skin), as well as pathogen- or malignancy-specific contexts. The projects of Research Area B: "Molecular and cellular regulation of T lymphocytes" focus on different signaling pathways and their impact on T cell development, activation and effector functions. Profound expertise in biochemistry will be combined with novel in vivo signaling reporter systems (biosensors) to study signaling processes regulating the dynamics of T cell differentiation or their local and systemic interactions with other cells. The TWIN projects - embedded in both Area A and Area B and connecting them - result from the paradigm shift that the brain can no longer be viewed as an immune-privileged organ, separated from the immune system by the blood-brain barrier. Instead it is now well established that the CNS and the immune system constantly interact with each other and influence each other’s functions. Therefore the TWIN projects address the question how communication between the immune system and the CNS is molecularly regulated.Taken together, CRC854 aims to understand the molecular mechanisms of signal processing during physiological and pathophysiological immune responses, and to connect intracellular signaling mechanisms with the dynamics of intercellular interactions. To achieve these goals, CRC854 will create added value by combining the local expertise in the fields of immunology and neuroscience. In addition, CRC854 did and further will establish new model systems and methodologies for the investigation of molecular mechanisms determining immune activation and dysregulation.
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