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Institution
Universitätsklinikum Carl Gustav Carus Dresden
Medizinische Klinik und Poliklinik III
Bereich Endokrinologie, Diabetes und Knochenstoffwechselerkrankungen
Address
Fetscherstraße 74
01307 Dresden
Deutschland
GERiT
This institution in GERiT
01307 Dresden
Projects
Research Grants
Current projects
In vivo role of FLT3-CD45 signalling for bone remodelling
(Applicants
Hofbauer, Lorenz C.
;
Müller, Jörg P.
;
Rauner, Martina
)
Role of the transferrin receptor 2 (Tfr2) in the pathogenesis of inflammatory arthritis
(Applicant
Ledesma Colunga, Ph.D., Maria G.
)
TGF-β signaling inhibits osteoanabolic response to PTH in Osteogenesis Imperfecta
(Applicant
Grafe, Ingo Alexander
)
Completed projects
Dissecting the role of Dkk-1 in the pathogenesis of postmenopausal osteoporosis
(Applicant
Thiele, Sylvia
)
Einfluss von Tyrosinkinase-Inhibitoren auf das wachsende Skelettsystem
(Applicants
Hofbauer, Lorenz C.
;
Suttorp, Meinolf
)
FGF-23 as a novel mediator in osteohematology
(Applicants
Platzbecker, Uwe
;
Rauner, Martina
)
Novel biomarkers for bone metastases – from mechanism to analytics and back
(Applicants
Hofbauer, Lorenz C.
;
Rachner, Tilmann
;
Rauner, Martina
)
Osteoklasten-assoziierter Rezeptor (OSCAR) als Bindeglied zwischen oxidativem Stress und Gefäßkalzifizierung
(Applicant
Göttsch, Ph.D., Claudia
)
RANK-Ligand und Osteoprotegerin als Regulatoren des vaskulären und skeletalen Systems
(Applicant
Hofbauer, Lorenz C.
)
Regulation of microglia-mediated neuroinflammation by microneurotrophins
(Applicant
Alexaki, Vasileia Ismini
)
Regulation of osteoprotegerin ligand and osteoprotegerin production in human osteoblasts
(Applicant
Hofbauer, Lorenz C.
)
Role of a Neuropilin-2/CXCR4 signaling pathway in the formation of prostate cancer bone metastases
(Applicants
Dubrovska, Anna
;
Hofbauer, Lorenz C.
;
Muders, Michael Helmut
)
The role of MAPK 38 in resistance of breast cancer and osteolytic bone metastases to inhibitors of the mevalonate pathway
(Applicants
Hofbauer, Lorenz C.
;
Rachner, Tilmann
)
Untersuchung des Knochenstoffwechsels in der HLA-B27-transgenen Ratte - einem Modell der ankylosierenden Sponyloarthritis
(Applicant
Rauner, Martina
)
Heisenberg Fellowships
Completed projects
Rank-Ligand und Osteoprotegerin als gemeinsame Regulatoren des kardiovaskulären und skeletalen Systems
(Applicant
Hofbauer, Lorenz C.
)
Research Units
Current projects
Coordination Funds
(Applicant
Rauner, Martina
)
Dissecting the bone cell-specific functions of ferroportin
(Applicants
Altamura, Sandro
;
Hofbauer, Lorenz C.
)
FOR 5146: Defining the osteohepatic axis in the context of iron homeostasis - FerrOs
(Spokesperson
Rauner, Martina
)
Impact of iron and anemia on bone metabolism and fractures
(Applicants
Burden, Ph.D., Andrea
;
Hofbauer, Lorenz C.
;
Steinbicker, Andrea Ulrike
)
Mechanisms of Tfr1-mediated iron uptake in bone and effects of iron on bone cell bioenergetics
(Applicant
Rauner, Martina
)
Completed projects
Central administration and tissue banking
(Applicant
Hofbauer, Lorenz C.
)
Central administration, tissue banking, and clinical translation.
(Applicant
Hofbauer, Lorenz C.
)
Dickkopf-1 as a critical determinant of malignant bone disease
(Applicants
Rachner, Tilmann
;
Rauner, Martina
)
FOR 1586: SKELMET - Mesenchymal and Osteogenic Signalling Pathways in Malignant Bone Diseases
(Spokesperson
Hofbauer, Lorenz C.
)
Interactions of the WNT and RANKL/OPG pathways in osteomimicry of prostate cancer
(Applicant
Hofbauer, Lorenz C.
)
Role of Wnt5a in the interactions of prostate cancer cells and the bone microenvironment.
(Applicant
Hofbauer, Lorenz C.
)
Priority Programmes
Current projects
Coordination Funds
(Applicant
Hofbauer, Lorenz C.
)
Deciphering pathogenesis, treatment and reversibility of myeloma bone disease at a single cell resolution
(Applicants
Merz, Maximilian
;
Weidner, Heike
)
Investigating the role of osteocyte steatosis as underlying mechanisms of the impaired osteocyte network due to bone metastasis
(Applicants
Busse, Björn
;
Rauner, Martina
)
Role of Dickkopf-1 as a mediator of inflammation in osteotropic cancers
(Applicants
Göbel, Andy
;
Rachner, Tilmann
)
The impact of hypoxia pathway proteins in bone marrow niche cells during metastasis homing to bone
(Applicants
Rauner, Martina
;
Wielockx, Ph.D., Ben
)
Completed projects
Characterization of the impact of bone-seeking tumors on the osteocyte network and the osteocyte-mediated regulation of bone turnover
(Applicants
Busse, Björn
;
Raum, Kay
;
Rauner, Martina
)
Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss
(Applicants
Hofbauer, Lorenz C.
;
Rauner, Martina
)
Dissecting the pleiotropic effects of Dickkopf-1 in homing and colonization of breast cancer cells to and within bone.
(Applicants
Göbel, Andy
;
Rachner, Tilmann
)
Dissecting the role of extracellular vesicles and their miRNA cargo in prostate cancer. From expression pattern to bone metastasis phenotype.
(Applicants
Conrad, Stefanie
;
Hofbauer, Lorenz C.
)
Interplay between the Immune System and the Bone in the SWAP-70-/-mouse
(Applicant
Garbe, Annette
)
Role of Wnt signaling in classical and non-classical thyroid hormone actions (T0-T4) on bone
(Applicants
Hofbauer, Lorenz C.
;
Rauner, Martina
)
SPP 2084: µBONE: Colonization and interaction of tumor cells within the bone microenvironment
(Spokesperson
Hofbauer, Lorenz C.
)
Research Fellowships
Completed projects
Dysregulation im Matrix-Zell-Signalingin rezessiven Formen der Osteogenesis imperfecta
(Applicant
Grafe, Ingo Alexander
)
CRC/Transregios
Current projects
Adrenal stem cells under homeostatic and stress conditions
(Project Heads
Andoniadou, Ph.D., Cynthia L.
;
Bornstein, Ph.D., Stefan R.
;
Schedl, Andreas
;
Steenblock, Charlotte
)
Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
;
Schett, Georg
;
Tsourdi, Elena
)
Consequences of gut-imprinted immune cell trafficking for bone homeostasis
(Project Heads
Salbach-Hirsch, Juliane
;
Zundler, Sebastian
)
Defining the regulation and role of bone marrow adipocytes during inflammatory bone loss
(Project Head
Rauner, Martina
)
Defining the role of osteomorphs in inflammatory bone loss
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
)
Information Infrastructure for the CRC/TRR 369
(Project Heads
Müller-Pfefferkorn, Ralph
;
Rauner, Martina
)
Completed projects
Effects of sulfated glycosaminoglycans on bone regeneration through interactions with Wnt inhibitors
(Project Heads
Hofbauer, Lorenz C.
;
Hofbauer, Christine
)
Sulfated glycoaminoglycans as coating for endoprostheses to improve osseointegration
(Project Heads
Hofbauer, Lorenz C.
;
Rammelt, Stefan
;
Schnabelrauch, Matthias
)
DFG Research Centres
Completed projects
Bone/Cartilage: Hard Tissue Replacement
(Project Heads
Hofbauer, Lorenz C.
;
Lauer, Günter
)
Collaborative Research Centres
Completed projects
Iron regulation of the hematopoietic stem and progenitor cell niche
(Project Heads
Hofbauer, Lorenz C.
;
Platzbecker, Uwe
)
International Research Training Groups
Current projects
GRK 2251: Immunological and Cellular Strategies in Metabolic Disease (ICSMD)
(Spokesperson
Bornstein, Ph.D., Stefan R.
)
Clusters of Excellence
Completed projects
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
(Spokespersons
Bonifacio, Ph.D., Ezio
;
Brand, Michael
;
Calegari, Ph.D., Federico
;
Tanaka, Ph.D., Elly Margaret
)
Additional Information
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