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Project Details

Institution

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Max-Planck-Institut für Herz- und Lungenforschung
W. G. Kerkhoff-Institut
Abteilung für Pharmakologie

Address Ludwigstraße 43
61231 Bad Nauheim
Deutschland

GERiT This institution in GERiT

61231 Bad Nauheim

Projects

Priority Programmes
- Completed projects
  - Konditionelle Inaktivierung des G alpha q-Gens in verschiedenen Geweben der Maus
    (Applicant Offermanns, Stefan )
  - Regulation of the actin cytoskeleton via the RhoGEF proteins PDZ-RhoGEF/LARG
    (Applicant Offermanns, Stefan )
Research Grants
- Current projects
  - Investigation on the pharmacological aspects underlying the antidiabetic effects of a thromboxane receptor (TP) antagonist
    (Applicants Offermanns, Stefan ; Scholich, Ph.D., Klaus )
  - Modulation of neuroinflammation by novel endothelial GPCRs
    (Applicants Schwaninger, Markus ; Wettschureck, Nina )
- Completed projects
Research Units
- Completed projects
  - Rolle von G12/G13 im Rahmen der Calcium-unabhängigen Regulation des Tonus glatter Gefäßmuskeln
    (Applicant Offermanns, Stefan )
Collaborative Research Centres
- Current projects
  - Cardiovascular damage protection by APP/APLP2
    (Project Head Offermanns, Stefan )
  - Damage-induced adaptation of G protein-coupled receptor signalling
    (Project Head Wettschureck, Nina )
  - G protein-coupled receptors orchestrating granulocytes in pemphigoid diseases
    (Project Heads Sadik, Christian David ; Wettschureck, Nina )
  - Novel G-protein-coupled receptors for fatty acids and other lipids
    (Project Head Offermanns, Stefan )
  - Regulation of prostanoid receptor signaling by orphan GPCRs of the GPRC5 family
    (Project Head Wettschureck, Nina )
  - SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
    (Spokesperson Pfeilschifter, Josef M. )
- Completed projects
  - G-Protein-coupled receptors in endothelial cells: from single-cell expression to new functions
    (Project Head Wettschureck, Nina )
  - Modulation der Leukozytenfunktion durch heterotrimere G Proteine der Familien Gq/G11 und G12/G13
    (Project Heads Offermanns, Stefan ; Wettschureck, Nina )
  - Regulation und Funktion der G-Proteine G12 und G13
    (Project Heads Offermanns, Stefan ; Schultz, Günter )
  - Role of Gq/G11- and G12/G13-mediated signalling in the development of the vervous system
    (Project Head Offermanns, Stefan )
  - Signalling pathways mediating endothelial flow sensing and inflammatory activation
    (Project Heads Offermanns, Stefan ; Wettschureck, Nina )
  - Untersuchungen zur Funktion von G-Proteinen der Gq- und G12-Subfamilien in Ga-defizienten Systemen
    (Project Head Offermanns, Stefan )
CRC/Transregios
- Completed projects
  - Interplay between pro-inflammatory cytokines and chromatin-remodeling enzymes in the regulation of central nervous system demyelination and repair
    (Project Heads Jacob, Claire ; Waisman, Ari ; Wettschureck, Nina )
  - Mechanisms regulating vascular smooth muscle cell differentiation
    (Project Heads Offermanns, Stefan ; Wettschureck, Nina )
Research Training Groups
- Completed projects
  - GRK 791: Neural Developmental and Degenerative Processes: Basic Research and Clinical Implications
    (Spokesperson Monyer, Hannah )
Clusters of Excellence
- Completed projects
  - EXC 147: Cardio-Pulmonary System
    (Spokespersons Dimmeler, Stefanie ; Seeger, Werner ; Zeiher, Andreas Michael )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2026: Cardio-Pulmonary Institute (CPI)
    (Spokespersons Dimmeler, Stefanie ; Seeger, Werner )

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