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Institution
Universitätsklinikum Köln
Center for Molecular Medicine in Cologne (CMMC)
Address
Robert-Koch-Straße 21
50931 Köln
Deutschland
GERiT
This institution in GERiT
50931 Köln
Projects
Research Grants
Current projects
Deciphering cell-autonomous and non-autonomous mechanisms of cell death function in skin regeneration
(Applicant
Niemann, Catherin
)
Deciphering the human B cell response to develop neutralizing antibodies against Enterococcus faecalis
(Applicant
Simonis, Alexander
)
Mechanisms of Caspase-8/cFLIP heterodimer-mediated cell death regulation in homeostatic and pathological conditions
(Applicant
Annibaldi, Ph.D., Alessandro
)
Mechanisms of co-translational quality control during the synthesis of CFTR
(Applicant
Broch Trentini Schmidt, Ph.D., Débora
)
Structural analyses of the assembly, chromatin recognition and modification of the human KMT2D complex
(Applicant
Pöpsel, Simon
)
Structure, biology and medical potential of blood plasma-derived ultra-short cell-free DNA
(Applicant
Hänsel-Hertsch, Ph.D., Robert
)
Completed projects
Biosynthese und Funktionen der terminalen Glukuronsäure im Glukuronyl-T- und HNK-1-Antigen von Drosophila melanogaster
(Applicant
Hanisch, Franz-Georg
)
Die Rolle der Rezyklisierung in der O-Glykosylierung des transmembranären Glykoproteins MUCI
(Applicant
Hanisch, Franz-Georg
)
Herstellung und Charakterisierung von anti-MUC1-scFv-Interleukin-2 Antikörper-Zytokin-Fusionsproteinen für die Immuntherapie zur Aufhebung der MUC1-induzierten, lokalen zellulären Immunsuppression durch MUC1-positive Karzinome
(Applicant
Abken, Hinrich
)
Indian Hedgehog signalling in epidermal differentiation and sebaceous tumour formation
(Applicant
Niemann, Catherin
)
In situ Sequenzierung komplexer Mucin-Glykane durch PSD-MALDI(TOF)-Massenspektrometrie: Native und rekombinante Glykoformen des MUC1 in der immunologischen Prozessierung/MHC-Präsentation
(Applicant
Hanisch, Franz-Georg
)
Protein-spezifische O-Glykosylierung: Stehen periphere LacdiNAc-Modifikationen komplexer O-Glykane unter Kontrolle cis-lokalisierter Peptide?
(Applicant
Hanisch, Franz-Georg
)
Proteomanalyse O-glykosylierter Proteine
(Applicant
Hanisch, Franz-Georg
)
Sequence polymorphisms in the VNTR domain of the epithelical mucin MUC1
(Applicant
Hanisch, Franz-Georg
)
Studien zur Regulation der O-Glykanbiosynthese in vivo
(Applicant
Hanisch, Franz-Georg
)
Targetsequenzen der humanen O-Mannosyltransferase (POMT1/POMT2) in der O-Mannosylierung der alpha-Dystroglykan-Mucindomäne
(Applicant
Hanisch, Franz-Georg
)
Warum sind nonsense Mutationen in I(2)35Aa von Drosophila melanogaster letal ?. Aufklärung der essentiellen Funktionen der Polypeptid GalNAc-Transferase dGalNAc-T1 durch Glykoproteom-Analysen
(Applicant
Hanisch, Franz-Georg
)
Research Units
Current projects
Epigenetische Einflüsse auf die Genomstabilität bei der Homöostase von Säugetieren
(Applicant
Hänsel-Hertsch, Ph.D., Robert
)
FOR 5504: Physiological causes and consequences of genome instability
(Spokesperson
Schumacher, Björn
)
Completed projects
Central Protein Analysis
(Applicant
Hanisch, Franz-Georg
)
Collaborative Research Centres
Current projects
Clearance of defective mRNA by-products by the ribosome-associated quality control pathway in stress and disease
(Project Head
Broch Trentini Schmidt, Ph.D., Débora
)
Consequences of age-related G-quadruplex formation for the fidelity of mammalian transcription
(Project Head
Hänsel-Hertsch, Ph.D., Robert
)
Data management, data mining and image analysis
(Project Heads
Beyan, Oya
;
Bozek, Katarzyna
)
Decoding epigenetic subtypes, resistance mechanisms and vulnerabilities of small cell lung cancer
(Project Head
Hänsel-Hertsch, Ph.D., Robert
)
Mechanisms of locally controlled JARID1B histone demethylase activity
(Project Head
Pöpsel, Simon
)
Predicting therapy response and relapse of aggressive B cell lymphomas
(Project Heads
Bozek, Katarzyna
;
Büttner, Reinhard
)
Understanding the role of cFLIP in B cell lymphoma pathogenesis
(Project Head
Annibaldi, Ph.D., Alessandro
)
Completed projects
Central animal facility: Generation, breeding and husbandry of mice including murine infection models
(Project Heads
Kastenmüller, Wolfgang
;
Knolle, Percy Alexander
;
Mahabir-Brenner, Esther
;
Pasparakis, Manolis
;
Utermöhlen, Olaf
)
Hedgehog-Gli signalling in skin homeostasis and tumour formation
(Project Head
Niemann, Catherin
)
Specification of sebaceous lineage commitment in mammalian skin development
(Project Head
Niemann, Catherin
)
Zentrale Proteinanalyse
(Project Heads
Hanisch, Franz-Georg
;
Lamkemeyer, Tobias
)
Major Research Instrumentation
Completed projects
confocal laser scanning microscope
MALDI-TOF-TOF Massenspektrometer mit offline nano-HPLC-System
Research Fellowships
Completed projects
Role of IFN-gamma on innate immune cell-mediated protective mechanisms during Salmonella infection
(Applicant
Tebartz, Christina
)
Clinical Research Units
Current projects
Alterations of slit diaphragm proteins and the pathogenesis of albuminuria and FSGS
(Applicants
Benzing, Thomas
;
Bozek, Katarzyna
)
Central mouse generation, phenotyping and imaging
(Applicants
Bozek, Katarzyna
;
Schauss, Astrid
)
KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
(Spokesperson
Benzing, Thomas
)
Sequencing-based innovative approaches to study FSGS
(Applicants
Altmüller, Janine
;
Antczak, Philipp
;
Beck, Bodo
)
CRC/Transregios
Current projects
Data management and modeling of podocyte signaling networks across clinical and molecular landscapes in human and animal systems
(Project Heads
Antczak, Philipp
;
Beyan, Oya
;
Bonn, Stefan
)
Defending podocyte integrity against mechanical strain: Unveiling mechanosensitive multiprotein complex signaling at the slit diaphragm
(Project Heads
Benzing, Thomas
;
Bozek, Katarzyna
;
Butt, Linus
)
International Research Training Groups
Current projects
GRK 3110: Tumor Heterogeneity and Genomic Instability in Lung Cancer – From Basic Mechanisms to Clinical Implications
(Spokesperson
Büttner, Reinhard
)
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