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Institution
Albert-Ludwigs-Universität Freiburg
Fakultät für Chemie und Pharmazie
Institut für Pharmazeutische Wissenschaften
Address
Albertstraße 25
79104 Freiburg
Deutschland
GERiT
This institution in GERiT
79104 Freiburg
Projects
Research Grants
Current projects
Sirtuin-2 (Sirt2) ligands as inhibitors of lysine long-chain deacylation and chemical tools for protein degradation
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
Completed projects
Efficient Syntheses of Natural and Unnatural Benzotropolones and Pulvinones. Total Synthesis of the Fungal Dye Aurantricholone
(Applicant
Brückner, Reinhard
)
Epigenetic subversion in Leishmania macrophage infection (ELATION)
(Applicant
Jung, Manfred
)
Hemmstoffe NAD+-abhängiger Histon-Desacetylasen (Sirtuine)
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
Isotype selective sirtuin inhibitors
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
NAD+-abhängige Transferasen und deren Inhibitoren
(Applicants
Aktories, Klaus
;
Jung, Manfred
;
Sippl, Wolfgang
)
Neue Hemmstoffe der Histon-Deacetylase für Krebstherapie und Krebs-Chemoprävention
(Applicant
Jung, Manfred
)
Neue katalytische asymmetrische Reaktionen durch Thiamindiphosphat-abhängige Enzyme
(Applicants
Müller, Michael
;
Pleiss, Jürgen
;
Pohl, Martina
)
Structure based development and biological characterization of selective inhibitors of histone deacetylases (HDACs) 8 and 10.
(Applicants
Jung, Manfred
;
Oehme, Ina
;
Sippl, Wolfgang
;
Witt, Olaf
)
Target basierte Entwicklung neuer Hemmstoffe der Lysin-Dementhylase LSDI und deren Einfluss auf die Regulation des Androgenrezeptors
(Applicants
Jung, Manfred
;
Schüle, Roland
;
Sippl, Wolfgang
)
Priority Programmes
Completed projects
Epigenetic function of RUNX1 with PRMT6 in normal and aberrant myeloid differentiation
(Applicant
Lausen, Jörn
)
Reversible histone acetylation and its inhibitors in myeloid neoplasia
(Applicant
Jung, Manfred
)
Untersuchung zur stereoselektiven oxidativen Phenolkupplung in filamentösen Pilzen
(Applicant
Müller, Michael
)
Research Units
Current projects
Biosynthesis and utilisation of SAM diastereomers as tools for the characterisation of SAM-dependent enzymes and product diversification
(Applicant
Andexer, Jennifer
)
Coordination Funds
(Applicant
Andexer, Jennifer
)
Dearomatisation by asymmetric methylation
(Applicant
Müller, Michael
)
FOR 5596: Unfolding the potential of S-adenosylmethionine-dependent enzyme chemistry
(Spokesperson
Andexer, Jennifer
)
Integration of sequence and reaction data for the design and engineering of methionine adenosyltransferases and other SAM–dependent enzymes
(Applicants
Andexer, Jennifer
;
Pleiss, Jürgen
)
Completed projects
Catalytic asymmetric Stetter reaction
(Applicant
Müller, Michael
)
FOR 1296: Diversity of Asymmetric Thiamine Catalysis
(Spokesperson
Müller, Michael
)
Ketones and imines as substrates of ThDP-dependent enzymes
(Applicant
Müller, Michael
)
Zentralprojekt
(Applicant
Müller, Michael
)
Heisenberg Professorships
Completed projects
Flexible Biomimetic Systems for the Application of Cofactor-Dependent Enzymes
(Applicant
Andexer, Jennifer
)
Heisenberg Grants
Completed projects
Flexible Biomimetic Systems for the Application of Cofactor-Dependent Enzymes
(Applicant
Andexer, Jennifer
)
Clinical Research Units
Completed projects
Regulation of ciliogenesis and ciliary disassembly by nephrocystins
(Applicants
Jung, Manfred
;
Walz, Gerd
)
Research Fellowships
Completed projects
Studies on the monooxygenase, HsaAB - a cholesterol-degrading enzyme of M. tuberculosis
(Applicant
Dresen, Carola
)
Collaborative Research Centres
Completed projects
Chemical Epigenetics – Inhibitors of histone methyltransferases
(Project Head
Jung, Manfred
)
Chemoenzymatische Naturstoff- und Wirkstoffsynthese
(Project Head
Müller, Michael
)
Integrated Research and Training Group (IRTG)
(Project Head
Jung, Manfred
)
Major Research Instrumentation
Completed projects
Austauschkonsole für 400 MHz NMR-Spektrometer
International Research Training Groups
Completed projects
GRK 1038: Catalysts and Catalytic Reactions for Organic Synthesis
(Spokesperson
Breit, Bernhard
)
Research Training Groups
Completed projects
GRK 1976: Functional Diversity of Cofactors in Enzymes
(Spokesperson
Bechthold, Andreas
)
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