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Institution
Albert-Ludwigs-Universität Freiburg
Fakultät für Chemie und Pharmazie
Institut für Pharmazeutische Wissenschaften
Address
Albertstraße 25
79104 Freiburg
Deutschland
GERiT
This institution in GERiT
79104 Freiburg
Projects
Research Grants
Current projects
Epigenetic subversion in Leishmania macrophage infection (ELATION)
(Applicant
Jung, Manfred
)
Sirtuin-2 (Sirt2) ligands as inhibitors of lysine long-chain deacylation and chemical tools for protein degradation
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
Completed projects
Efficient Syntheses of Natural and Unnatural Benzotropolones and Pulvinones. Total Synthesis of the Fungal Dye Aurantricholone
(Applicant
Brückner, Reinhard
)
Hemmstoffe NAD+-abhängiger Histon-Desacetylasen (Sirtuine)
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
Isotype selective sirtuin inhibitors
(Applicants
Jung, Manfred
;
Sippl, Wolfgang
)
NAD+-abhängige Transferasen und deren Inhibitoren
(Applicants
Aktories, Klaus
;
Jung, Manfred
;
Sippl, Wolfgang
)
Neue Hemmstoffe der Histon-Deacetylase für Krebstherapie und Krebs-Chemoprävention
(Applicant
Jung, Manfred
)
Neue katalytische asymmetrische Reaktionen durch Thiamindiphosphat-abhängige Enzyme
(Applicants
Müller, Michael
;
Pleiss, Jürgen
;
Pohl, Martina
)
Structure based development and biological characterization of selective inhibitors of histone deacetylases (HDACs) 8 and 10.
(Applicants
Jung, Manfred
;
Oehme, Ina
;
Sippl, Wolfgang
;
Witt, Olaf
)
Target basierte Entwicklung neuer Hemmstoffe der Lysin-Dementhylase LSDI und deren Einfluss auf die Regulation des Androgenrezeptors
(Applicants
Jung, Manfred
;
Schüle, Roland
;
Sippl, Wolfgang
)
Priority Programmes
Completed projects
Epigenetic function of RUNX1 with PRMT6 in normal and aberrant myeloid differentiation
(Applicant
Lausen, Jörn
)
Reversible histone acetylation and its inhibitors in myeloid neoplasia
(Applicant
Jung, Manfred
)
Untersuchung zur stereoselektiven oxidativen Phenolkupplung in filamentösen Pilzen
(Applicant
Müller, Michael
)
Research Units
Current projects
Biosynthesis and utilisation of SAM diastereomers as tools for the characterisation of SAM-dependent enzymes and product diversification
(Applicant
Andexer, Jennifer
)
Coordination Funds
(Applicant
Andexer, Jennifer
)
Dearomatisation by asymmetric methylation
(Applicant
Müller, Michael
)
FOR 5596: Unfolding the potential of S-adenosylmethionine-dependent enzyme chemistry
(Spokesperson
Andexer, Jennifer
)
Integration of sequence and reaction data for the design and engineering of methionine adenosyltransferases and other SAM–dependent enzymes
(Applicants
Andexer, Jennifer
;
Pleiss, Jürgen
)
Completed projects
Catalytic asymmetric Stetter reaction
(Applicant
Müller, Michael
)
FOR 1296: Diversity of Asymmetric Thiamine Catalysis
(Spokesperson
Müller, Michael
)
Ketones and imines as substrates of ThDP-dependent enzymes
(Applicant
Müller, Michael
)
Zentralprojekt
(Applicant
Müller, Michael
)
Heisenberg Professorships
Completed projects
Flexible Biomimetic Systems for the Application of Cofactor-Dependent Enzymes
(Applicant
Andexer, Jennifer
)
Heisenberg Grants
Current projects
Flexible Biomimetic Systems for the Application of Cofactor-Dependent Enzymes
(Applicant
Andexer, Jennifer
)
Clinical Research Units
Completed projects
Regulation of ciliogenesis and ciliary disassembly by nephrocystins
(Applicants
Jung, Manfred
;
Walz, Gerd
)
Research Fellowships
Completed projects
Studies on the monooxygenase, HsaAB - a cholesterol-degrading enzyme of M. tuberculosis
(Applicant
Dresen, Carola
)
Collaborative Research Centres
Completed projects
Chemical Epigenetics – Inhibitors of histone methyltransferases
(Project Head
Jung, Manfred
)
Chemoenzymatische Naturstoff- und Wirkstoffsynthese
(Project Head
Müller, Michael
)
Integrated Research and Training Group (IRTG)
(Project Head
Jung, Manfred
)
Major Research Instrumentation
Completed projects
Austauschkonsole für 400 MHz NMR-Spektrometer
International Research Training Groups
Completed projects
GRK 1038: Catalysts and Catalytic Reactions for Organic Synthesis
(Spokesperson
Breit, Bernhard
)
Research Training Groups
Completed projects
GRK 1976: Functional Diversity of Cofactors in Enzymes
(Spokesperson
Bechthold, Andreas
)
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