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Klinikum der Technischen Universität München (TUM Klinikum)
Klinik und Poliklinik für Innere Medizin I: Kardiologie

Address Ismaninger Straße 22
81675 München
Deutschland

GERiT This institution in GERiT

81675 München

Projects

Research Grants
- Current projects
  - Impact of Gene-editing on the Arrhythmogenic Phenotype of Duchenne Muscular Dystrophy (DMD)
    (Applicant Raad, Ph.D., Nour )
  - Multiscale functional mapping of cell identity decisions in PDAC initiation
    (Applicants Moretti, Ph.D., Alessandra ; Rad, Roland )
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Funktionelle Analyse von membranären und zytoskeletalen Proteinen für die Myokardfunktion in vivo
    (Applicant Laugwitz, Karl-Ludwig )
Research Units
- Current projects
- Completed projects
Independent Junior Research Groups
- Current projects
  - CRISPR-Heart: Engineering CRISPR editors for modeling and treating heart disease
    (Applicant Grünewald, Julian )
Priority Programmes
- Current projects
  - evaluating the therapeutic potential of gene editing in a pig model with a dominant negative mutation in the GUCY2D gene
    (Applicants Giesert, Florian ; Klymiuk, Nikolai )
  - USH1C porcine model utilisation: assessing the function of USH1C/harmonin in the retina and conducting preclinical AAV-mediated gene augmentation therapy in the eye
    (Applicants Klymiuk, Nikolai ; Wolfrum, Uwe )
- Completed projects
  - Therapeutic Coronary Angiogenesis and Arteriogenesis Induced by Retroinfusion of Liposomal cDNA encoding for eNOS S1177D: Comparison to fluid shear stress (FSS) induction
    (Applicant Boekstegers, Peter )
Research Fellowships
- Completed projects
  - Engineering High Specificity DNA Base Editors for Programmable Genome Editing
    (Applicant Grünewald, Julian )
  - Significance and Management of Early Recurrences during Blanking Period After Catheter Ablation for Paroxysmal and Persistent Atrial Fibrillation
    (Applicant von Olshausen, Gesa )
Clinical Trials
- Current projects
  - Smartwatches for detection of atrial fibrillation (AFib) in secondary prevention of cryptogenic stroke - WATCH AFib
    (Applicant Wunderlich, Silke )
Collaborative Research Centres
- Completed projects
  - Multiscale functional mapping of cell identity decisions in PDAC initiation
    (Project Heads Moretti, Ph.D., Alessandra ; Rad, Roland )
  - Prognose bei Patienten mit Herzrhytmusstörungen
    (Project Heads Schmidt, Georg ; Ulm, Kurt )
  - Ultrasound-based molecular imaging
    (Project Heads Jiang, Xiaoyi ; Stypmann, Jörg ; Tiemann, Klaus )
Major Research Instrumentation
- Completed projects
  - Mikro-Ultraschallgerät für Kleintiere
CRC/Transregios
- Current projects
  - Alternative splicing regulation in the cardiac system by CTCF and lncRNA interaction
    (Project Heads Grote, Phillip ; Laugwitz, Karl-Ludwig )
  - Cell-specific genome editing to decipher the hypertrophic effect of Meg3
    (Project Heads Bähr, Andrea ; Kupatt, Christian ; Schnieke, Angelika )
  - Macrophage lncRNAs in heart repair
    (Project Heads Dueck, Anne ; Engelhardt, Stefan ; Moretti, Ph.D., Alessandra )
  - Patient-specific induced pluripotent stem cell models to elucidate the role of TRPM4 channels in the pathogenesis of inherited cardiac arrhythmia
    (Project Heads Laugwitz, Karl-Ludwig ; Lipp, Ph.D., Peter ; Moretti, Ph.D., Alessandra )
- Completed projects
  - Genetically engineered donor pigs with improved pancreatic islets
    (Project Heads Böttcher, Anika ; Kemter, Elisabeth Gabriele ; Klymiuk, Nikolai ; Wolf, Eckhard ; Wünsch, Annegret )
  - Immunogenicity of islets of different clinically relevant sources in a preclinical humanized mouse model
    (Project Heads Klymiuk, Nikolai ; Linkermann, Andreas ; Ludwig, Barbara ; Waskow, Claudia )
  - Local immunomodulation by viral vectors and genetic modifications
    (Project Heads Bähr, Andrea ; Hinkel, Rabea ; Kupatt, Christian ; Michel, Sebastian ; Murray, Peter J. )
  - Non-coding RNA control of cardiac repolarisation
    (Project Heads Engelhardt, Stefan ; Moretti, Ph.D., Alessandra )

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