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Institution
Universitätsklinikum Ulm
Zentrum für Innere Medizin
Klinik für Innere Medizin I
Address
Albert-Einstein-Allee 23
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Research Grants
Current projects
Association of prevalent driver mutations with regulation of sEV-release and cargo content to modulate tumor progression, metastasis and treatment resistance of pancreatic cancer.
(Applicant
Eiseler, Tim
)
Examination of the therapeutic potential of TNK1 in prevention and healing of intestinal barrier breach
(Applicant
Armacki, Ph.D., Milena
)
Mechanisms of pancreatic cancer cell resistance to T cell-mediated cytotoxicity
(Applicant
Lin, Ph.D., Yuan-Na
)
Spatio-temporal deletion of the Ataxia-telangiectasia mutated kinase (Atm) to dissect pancreatic cancer heterogeneity
(Applicant
Perkhofer, Lukas
)
Completed projects
1. "Role of dendritic cells in induction or prevention of colitogenic CD4 T cell responses" and 2. "Priming tolerogenic and colitogenic CD4 T cells in the murine gut"
(Applicants
Frick, Julia-Stefanie
;
Niess, Jan-Hendrik
)
Apoptose-auslösenden Mechanismen der Tyrosinkinase TNK1: Funktionelle Charakterisierung des Signalkontextes und möglicher Einsatz in der Tumortherapie
(Applicant
Seufferlein, Thomas
)
Bedeutung von Proteinkinase D (PKD)/Proteinkinase Cmy (PKCmy) und Proteinkinase D2 (PKD2) für Proliferation, Differenzierung und Transformation von Colonepithelien GEM mit WO 685/9-1, -/9-2
(Applicant
Seufferlein, Thomas
)
Die Rolle der Netzwerk-Morphologie für die Regulation viskoelastischer Eigenschaften des Keratin-Zytoskeletts in Zellen Pankreaskarzinoms
(Applicants
Beil, Michael
;
Marti, Othmar
;
Schmidt, Volker
;
Walther, Paul
)
Exploring Foxp3+ CD4+ Treg cell-stimulating vaccines to inhibit preproinsulin-specific effector CD8+ T cells and autoimmune diabetes
(Applicant
Schirmbeck, Reinhold
)
Exploring immune modulating strategies to restore antiviral effector functions of intrahepatic CD8 T cells
(Applicant
Schirmbeck, Reinhold
)
Funktion des IL-20R2 in antigenspezifischen T-Zell Antworten und der Delayed-Type Hypersensitivitätsreaktion der Haut
(Applicant
Oswald, Franz
)
Funktionelle Charakterisierung des neuen RNA bindenden Proteins KOC in Embryogenese und Kanzerogenese
(Applicant
Müller-Pillasch, Friederike
)
Hepatozellulärer Phosphatidylcholin- und Cholesterintransport in die Galle
(Applicant
Fuchs, Michael
)
Immunogenicity of recombinant chaperone-complexed antigens
(Applicant
Schirmbeck, Reinhold
)
Intrahepatic T cell responses to hepatotropic viruses in transgenic mice with inducible viral gene expression in the liver
(Applicant
Wirth, Dagmar
)
Investigation of the transcriptional regulation of the Na+/I-symporter (NIS) gene in view of its use in radioiodine therapy of thyroid cancer
(Applicant
Loos, Ulrich
)
Isolierung und funktionelle Charakterisierung des RBP-Jk/SHARP abhängigen Repressorkomplexes im Notch Signaltransduktionsweg
(Applicant
Oswald, Franz
)
Liver-specific gene inactivation and analysis of gene clusters employing a mouse model of cholesterol gallstone disease
(Applicant
Fuchs, Michael
)
Modulation lokaler Immunreaktionen in der Leber durch IL-10 homologe Zytokine
(Applicant
Wegenka, Ursula
)
Priming specific, murine CD8+ T cell responses by complexes of cationic/ antigenic fusion peptides with nucleic acids
(Applicant
Schirmbeck, Reinhold
)
Probing complex assembly and dynamics of the transcription factor RBPJ by live cell single-molecule microscopy
(Applicants
Gebhardt, Christof
;
Oswald, Franz
)
Regulation kolitogener CD4+ T-Zellreaktionen in der Darmmukosa monokolonisierter Mäuse
(Applicant
Reimann, Jörg
)
Regulation of protein transport and neuroendocrine secretion by the ARF1-PKD complex at the Trans-Golgi network
(Applicants
Seufferlein, Thomas
;
Sinz, Andrea
)
Regulation und Modulation der unspezifischen und spezifischen Immunität in der murinen Leber durch das Hepatitis C Virus core Protein
(Applicant
Wegert, Mona
)
Rekonstitution anti-viraler CD8 T Zellimmunität im präklinischen Modell der chronischen HBV Infektion durch Immunisierung mit natürlichen Antigenvarianten
(Applicant
Riedl, Petra
)
Restoring the functionality of the old immune system by rejuvenation of aged hematopoietic stem cells
(Applicants
Geiger, Hartmut
;
Schirmbeck, Reinhold
)
Role of Protein Kinase D1 in the regulation of endothelial permeability after blunt chest trauma.
(Applicant
Eiseler, Tim
)
Roles of Protein Kinase D2 during actin-driven vesicle scission at the Trans-Golgi-network (TGN).
(Applicant
Eiseler, Tim
)
Rolle der Protein Kinase D Isoenzyme bei der Regulation von Zell-Zell- und Zell-Matrix-Interaktionen, welche die Progression von Pankreas Tumoren beeinflussen
(Applicant
Eiseler, Tim
)
Specific CD8+ T cell immunity in the murine liver
(Applicant
Reimann, Jörg
)
Synthese, Struktur und physikalische Eigenschaft von Keratin-Polymeren und -Netzwerken
(Applicants
Beil, Michael
;
Herrmann, Harald
;
Langowski, Jörg
;
Marti, Othmar
;
Walther, Paul
)
The role of lsc/p115-RhoGEF-regulated pathways for development and function of the enteric nervous system in the upper gastrointestinal tract.
(Applicant
Zizer, Eugen
)
The role of PKD2 in HSP90,- hypoxia- and TGF beta-mediated epithelial-to-mesenchymal transition and metastasis
(Applicant
Azoitei, Ninel
)
Clinical Research Units
Completed projects
Apoptose-auslösende Mechanismen der Tyrosinkinase TNK1: Funktionelle Charakterisierung des Signalkontexts und möglicher Einsatz in der Tumortherapie
(Applicant
Seufferlein, Thomas
)
Die Regulation muriner, anti-viraler CD8+ T-Zellantworten mit fortschreitendem Alter
(Applicant
Reimann, Jörg
)
Die Regulation muriner CD8+ T-Zellantworten mit fortschreitendem Alter
(Applicant
Schirmbeck, Reinhold
)
Endo-Radiotherapie-basierte Konzepte für neuroendokrine Tumoren
(Applicant
Karges, Wolfram
)
Clinical Trials
Completed projects
Allogenic micobiota-reconstitution (AMR) for the treatment of patients with diarhea-predominant irritable bowel syndrome (IBS-D) - the AMIRA trial
(Applicant
Seufferlein, Thomas
)
Research data and software
Completed projects
Implementation of interfaces for the standardization of national database systems for alveolar echinococcosis and their transformation processes
(Applicant
Kratzer, Wolfgang
)
Collaborative Research Centres
Current projects
Clearance of Senescent Cells by Rejuvenation of the Aged Immune System
(Project Heads
Krizhanovsky, Ph.D., Valery
;
Schirmbeck, Reinhold
)
Notch/NF-KB crosstalk at the aging synapse: Role of inflammaging on cognitive decline
(Project Heads
Baumann, Bernd
;
Oswald, Franz
)
Therapeutic targeting of small extracellular vesicle (sEV) release and uptake in post-traumatic hyper-inflammation
(Project Head
Seufferlein, Thomas
)
Completed projects
Bedeutung der NFAT-Transkriptionsfaktoren für das phänotypische Verhalten des Pankreaskarzinoms
(Project Heads
Ellenrieder, Volker
;
Oswald, Franz
)
CCK-induzierte Mechanismen der F-Aktin-Regulation in der Azinuszelle
(Project Heads
Beil, Michael
;
Lutz, Manfred
)
Functional Characterization of Autoreactive T Cells in Type 1 Diabetes mellitus
(Project Heads
Böhm, Bernhard Otto
;
Rosinger, Silke
)
Identification of the subcellular localization and cellular targets of protein kinase D2, a novel protein kinase overexpressed in pancreatic cancer.
(Project Head
Seufferlein, Thomas
)
Induction and control of autoreactive, preproinsulin-specific CD8 T cells in transgene mouse models of typ 1 diabetes
(Project Heads
Böhm, Bernhard Otto
;
Schirmbeck, Reinhold
)
Isolierung und funktionelle Charakterisierung des RBP-Jk/SHARP abhängigen Repressorkomplexes im Notch Signaltranduktionsweg
(Project Head
Oswald, Franz
)
Molecular analysis of NF-KappaB- induced acute pancreatitis and of the pan creatitis induced fibrosis
(Project Heads
Baumann, Bernd
;
Wagner, Martin
)
Molecular characterization of acinar-ductal metaplasie in TGF-alpha transgenic mice
(Project Head
Wagner, Martin
)
Notch signaling as a novel target of AML/ETO
(Project Heads
Geiger, Hartmut
;
Oswald, Franz
)
On the role of EMMPRIN and its interaction with pancreatic stellate cells in fibrogenesis und tumor desmoplasia
(Project Heads
Bachem, Max G.
;
Schneiderhan, Wilhelm
)
Regulation of endocrine and neuroendocrine secretion in the pancreas by the protein kinase D family
(Project Heads
Seufferlein, Thomas
;
Walther, Paul
;
von Wichert, Götz Peter
)
Regulation of the viscoelastic properties of the keratin cytoskeleton in pancreatic carcinoma cells
(Project Heads
Beil, Michael
;
Marti, Othmar
)
Targeting CXCR4 signaling to eliminate metastatic cancer stem cells in pancreatic cancer
(Project Head
Hermann, Patrick C.
)
The role of the RBP-J(kappa) dependent corepressor protein CtIP in pancreatic development and differentiation
(Project Head
Oswald, Franz
)
Major Research Instrumentation
Completed projects
Konfokales Hochdurchsatz-Screening Laser-Raster Mikroskop
Research Fellowships
Completed projects
Cancer cell subpopulation and host crosstalk during metastasis of pancreatic ductal adenocarcinoma (PDAC)
(Applicant
Lin, Ph.D., Yuan-Na
)
Research Training Groups
Completed projects
GRK 460: Diagnostic and Therapeutic Concepts in Molecular Medicine
(Spokesperson
Lehmann-Horn, Frank
)
GRK 1041: Molecular Diabetology and Endocrinology in Clinical Medicine
(Spokesperson
Böhm, Bernhard Otto
)
GRK 1789: Cellular and Molecular Mechanisms in Aging (CEMMA)
(Spokesperson
Geiger, Hartmut
)
GRK 2254: Heterogeneity and evolution in solid tumors (HEIST): Molecular characterization and therapeutic consequences
(Spokesperson
Seufferlein, Thomas
)
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