TRR 221:  Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation

• Subject Area: Medicine
• Term: since 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• A01 - Deciphering the role of DM-sensitive and DM-resistant antigens in immune responses after ASCT (Project Heads Kremer, Anita ;  Mackensen, Andreas ;  Reimann, Hannah )
• A02 - Efficacy and safety of HLA-DPB1-specific chimeric antigen receptors (CAR) as mediators of GvL effect (Project Heads Herr, Wolfgang ;  Schlegel, Patrick ;  Thomas, Simone )
• A03 - Advanced CAR T cell engineering to augment the GvL effect of ASCT (Project Heads Danhof, Sophia ;  Einsele, Hermann ;  Hudecek, Michael )
• A06 - Metabolic stress related immune alterations with impact on GvL effect in ASCT (Project Heads Luu, Maik ;  Mackensen, Andreas ;  Mougiakakos, Dimitrios )
• A07 - Enhancing GvL responses by donor-derived CAR-modified CD8+ T memory stem cells (Project Heads Gattinoni, Luca ;  Harrer, Dennis )
• A08 - Timed targeting of cGAS/STING to improve tissue regeneration and anti-tumor responses following ASCT (Project Heads Poeck, Hendrik ;  Schmidl, Christian )
• A09 - Identification of T cell receptors and their epitopes mediating GvL responses in acute myeloid leukemia (AML) (Project Head Schober, Kilian )
• B02 - Targeting of TNFR2 and related molecules to separate graft-versus-host disease (GvHD) from the GvL effect (Project Heads Lang, Isabell ;  Wajant, Harald Günther )
• B03 - Generation, molecular characteristics and effector mechanisms of CSF2+ T cells in GvHD (Project Heads Hildner, Kai ;  Nganou Makamdop, Christiane Krystelle )
• B07 - GvHD therapy with donor regulatory T cells (Project Heads Edinger, Matthias ;  Hoffmann, Petra ;  Rehli, Michael )
• B08 - Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in GvHD (Project Heads Feuerer, Markus ;  Graw, Frederik )
• B09 - Regulation of tissue-resident myeloid cells controlling acute GvHD. (Project Heads Beilhack, Andreas ;  Gomez de Agüero, Mercedes )
• B10 - Dysregulation of the B cell compartment leading to chronic GvHD (Project Heads Müller, Fabian ;  Winkler, Thomas ;  Winkler, Julia ;  Wolff, Daniel )
• B11 - Targeting the reciprocal T cell-endothelial interactions after ASCT (Project Heads Beilhack, Andreas ;  Zernecke-Madsen, Alma )
• B12 - Regulation of the immune balance during ASCT by vitamin D3 (Project Heads Bruns, Heiko ;  Kreutz, Marina P. ;  Matos, Carina ;  Peter, Katrin )
• B13 - Enterococci in ASCT: Indicators of loss of diversity or true GvHD pathogens? (Project Heads Gessner, Ph.D., André ;  Holler, Ernst ;  Meedt, Elisabeth ;  Weber, Daniela )
• B14 - Role of EGF-like growth factors in immune regulation and tissue homeostasis during GvHD (Project Heads Shaikh, Ph.D., Muhammad Haroon ;  Zaiß, Dietmar M.W. )
• B15 - Elucidating inflammatory remodeling of the bone marrow niche after ASCT (Project Heads Grün, Dominic ;  Kraus, Sabrina )
• INF - Data integration platform and systems medicine efforts to foster GvL and GvHD research (Project Heads Dandekar, Thomas ;  Heinze, Katrin G. ;  Holler, Ernst ;  Kehr, Birte ;  Kunz, Meik ;  Meedt, Elisabeth ;  Taher, Leila )
• MGK - Integrated Research Training Group of TRR 221 (Project Heads Berberich-Siebelt, Friederike ;  Danhof, Sophia ;  Edinger, Matthias ;  Kremer, Anita ;  Nganou Makamdop, Christiane Krystelle ;  Walles, Heike )
• Z01 - Pathology and multi-omics work-up of GvHD and GvL in mice and men (Project Heads Büttner-Herold, Maike ;  Evert, Matthias ;  Hirsch, Daniela ;  Rosenwald, Andreas ;  Takats, Ph.D., Zoltan )
• Z02 - Animal engineering and complex transplantation models (Project Heads Beilhack, Andreas ;  Hoffmann, Petra ;  Pielmeier, Franziska ;  Winkler, Thomas )
• Z03 - Central tasks of the Collaborative Research Centre (Project Head Herr, Wolfgang )

Completed projects

• A04 - Novel tri-specific T-cell activating antibodies for personalized graft-versus-leukemia therapy (Project Heads Bargou, Ralf C. ;  Bumm, Thomas ;  Mokhtari, Ph.D., Zeinab ;  Stuhler, Gernot )
• A05 - Targeting novel immune check points in multiple myeloma and acute myeloid leukemia to improve allogeneic hematopoietic stem cell transplantation (Project Head Beckhove, Philipp )
• B01 - Therapeutic targeting of T-follicular cells in GvHD (Project Heads Berberich-Siebelt, Friederike ;  Spörl, Silvia )
• B04 - Aldehyde dehydrogenase 3A2 (ALDH3A2) as a novel regulator of inflammation and fibrotic tissue remodeling in sclerodermatous chronic graft-versus-host disease (Project Heads Distler, Jörg Hans Wilhelm ;  Jitschin, Ph.D., Regina ;  Spriewald, Bernd )
• B06 - Metabolic modification of mesenchymal stromal cells for harnessing their immunoregulatory capacity in graft-versus-host disease (Project Head Jitschin, Ph.D., Regina )

• Applicant Institution: Universität Regensburg
• Co-Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg; Julius-Maximilians-Universität Würzburg
• Participating Institution: Leibniz-Institut für Immuntherapie (LIT); Universitätsklinikum Magdeburg
• Spokesperson: Professor Dr. Wolfgang Herr