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Institution

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Goethe-Universität Frankfurt am Main
Fachbereich Biochemie, Chemie und Pharmazie
Institut für Pharmazeutische Chemie

Address Max-von-Laue-Straße 9
60438 Frankfurt am Main
Deutschland

GERiT This institution in GERiT

60438 Frankfurt am Main

Projects

Research Units
- Completed projects
  - Die Funktion der C2 Domäne der 5-Lipoxygenase bei der Regulation der Enzymaktivität
    (Applicant Steinhilber, Dieter )
  - Proteomic analysis of the presynaptic active zone from APP/APLP mutant mice
    (Applicants Karas, Michael ; Volknandt, Walter )
Research Grants
- Current projects
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Heisenberg-Stipendium Pharmaceutical Chemistry
    (Applicant Proschak, Eugen )
Independent Junior Research Groups
- Completed projects
  - Dynamic nature of RNA modifications and their influence in neurological diseases
    (Applicant Kaiser, Stefanie )
Heisenberg Professorships
- Completed projects
  - Heisenberg-Professur Pharmaceutical Chemistry
    (Applicant Proschak, Eugen )
Priority Programmes
- Completed projects
  - New tools for RNA modification dynamics analysis
    (Applicant Kaiser, Stefanie )
Heisenberg Grants
- Completed projects
  - Drug design
    (Applicant Proschak, Eugen )
WBP Position
- Current projects
  - Synthesis of spirocycles through C-H-activation and their application in medicinal chemistry
    (Applicant Hiesinger, Kerstin )
Collaborative Research Centres
- Current projects
  - Design and synthesis of pharmacological tools for G-protein coupled receptors of oxidized lipid mediators
    (Project Head Proschak, Eugen )
  - Development of selective inhibitors and PROTACs for key signalling molecules regulating cell state transitions and the cell cycle
    (Project Head Knapp, Stefan )
  - Discovery of novel RNA modifications and targets of RNA writer enzymes
    (Project Head Kaiser, Stefanie )
  - Integrated Research Training Group
    (Project Heads Carell, Thomas ; Daumann, Lena ; Kaiser, Stefanie ; Zipse, Hendrik )
  - Regulation of autophagy by microproteins and RNA modifications
    (Project Heads Dikic, Ivan ; Kaiser, Stefanie )
  - Targeting key drivers in SCLC for the development of new therapeutic concepts
    (Project Head Knapp, Stefan )
  - The noncanonical function of 5-lipoxygenase as a regulator of gene expression
    (Project Head Steinhilber, Dieter )
- Completed projects
  - Characterization of Membrane Protein Complexes
    (Project Heads Karas, Michael ; Schägger, Hermann )
  - Characterization of Membrane Protein Complexes
    (Project Heads Karas, Michael ; Schägger, Hermann )
  - Chemical biology analysis of epigenetics in SCLC
    (Project Head Knapp, Stefan )
  - Durchbrechung von Tumortoleranz durch allogene HLA-idente T-Zellen
    (Project Heads Herr, Wolfgang ; Karas, Michael )
  - Massenspektrometrische Analytik von RNA und RNA-Wirkstoffkomplexen
    (Project Head Karas, Michael )
  - Structural characterization of domain-domain interactions in autophagy
    (Project Heads Dötsch, Volker ; Knapp, Stefan )
  - Targeting selective autophagy in acute myeloid leukemia
    (Project Heads Brandts, Christian ; Knapp, Stefan )
Research Fellowships
- Completed projects
  - Quantification and Characterisation of the DNA phosphorothioate modification in the gut microbiome
    (Applicant Kaiser, Stefanie )
  - The design, synthesis and biological evaluation of PROTACs for CREBBP and p300
    (Applicant Heitel, Pascal )
Major Research Instrumentation
- Current projects
  - Automated liquid handling workstation
CRC/Transregios
- Current projects
  - Design of potent and selective USP25 and USP28 inhibitors
    (Project Heads Kisker, Caroline ; Proschak, Eugen )
  - Targeting E3 ligase functions in AML
    (Project Heads Knapp, Stefan ; Müller, Stefan )
Research Training Groups
- Current projects
  - GRK 2336: Resolution of inflammation – Mediators, signaling and therapeutic options
    (Spokesperson Brüne, Bernhard )
- Completed projects
  - GRK 137: Drugs: Development and Analytics
    (Spokesperson Müller, Walter E. )
  - GRK 1172: Research, Development and Safety of Biologicals
    (Spokesperson Pfeilschifter, Josef M. )
International Research Training Groups
- Completed projects
  - GRK 757: Roles of Eicosanoids in Biology and Medicine
    (Spokesperson Steinhilber, Dieter )
Clusters of Excellence
- Completed projects
  - EXC 115: Macromolecular Complexes
    (Spokespersons Dötsch, Volker ; Schwalbe, Harald )

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