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Institution
Universität Leipzig
Medizinische Fakultät
Rudolf-Boehm-Institut für Pharmakologie und Toxikologie
Address
Härtelstraße 16-18
04107 Leipzig
Deutschland
GERiT
This institution in GERiT
04107 Leipzig
Projects
Priority Programmes
Completed projects
Communication between cortical neurons and astrocytes by extracellular ATP and glutamate
(Applicant
Illes, Peter
)
Regulatoren heterotrimerer G-Proteine: Transgene Modelle für Phosducin
(Applicant
Lohse, Martin J.
)
Research Grants
Current projects
Function of Thy-1 (CD90) in the neuron – astrocyte communication
(Applicant
Saalbach, Anja
)
Inhibitor-induced counter-(up)regulation processes in gastric carcinoma: from secondary resistance mchanisms towards newly acquired tumor vulnerability
(Applicant
Aigner, Achim
)
MicroRNA mediated regulation of key components of the Mediator Complex (MED) and its functional role in CRPC
(Applicants
Aigner, Achim
;
Taubert, Helge
)
Novel nanoporous SiO2-based flexible foils and textiles as sustained release systems for the transdermal application of drugs
(Applicants
Aigner, Achim
;
Enke, Dirk
)
Novel polymeric nanoparticles for pulmonary nucleic acid therapy - synthesis, toxicological analysis and biological / therapeutic assessment
(Applicant
Aigner, Achim
)
The molecular role of selected circRNAs in cardiac macrophage dynamics and inflammatory response during cardiac remodeling after myocardial infarction
(Applicant
Jung, Ph.D., Mira
)
Completed projects
Analysis and therapeutic blocking of Exosome-miRNA tumor-derived signaling in colorectal carcinoma (Short title: Exo-antimiR)
(Applicant
Aigner, Achim
)
Behaviorally conditioned changes in peripheral immune functions: kinetics, affernet pathways and central processings
(Applicants
Krügel, Ute
;
Schedlowski, Manfred
)
Communication between cortical neurons and astrocytes by extracellular ATP and glutamate
(Applicant
Illes, Peter
)
Control of neuronal activity by the co-transmitter ATP: Role of P2Y1 receptors
(Applicant
Hirnet, Daniela
)
Effekte von Nukleotiden im mesocorticolimbischen dopaminergen System
(Applicant
Illes, Peter
)
Einfluss struktureller Modifikationen von P2X3-Rezeptoren
(Applicant
Illes, Peter
)
Gemeinsame Grundlagen von physiologischen Belohnungs- und pathopysiologischen Sensibilisierungsprozessen - Beteiligung purinerger Mechanismen
(Applicant
Kittner, Holger
)
Mechanismen der Gq/11- und G12/13- abhängigen Wachstumsregulation im kleinzelligen Bronchialkarzinom
(Applicants
Aigner, Achim
;
Gudermann, Thomas
)
Modification of the gut-brain dopamine axis as a cause of altered food reward processing and weight loss maintenance after Roux-en-Y gastric bypass surgery in a rodent model
(Applicants
Fenske, Wiebke Kristin
;
Krügel, Ute
;
Seyfried, Florian
)
Novel therapeutic strategies in gliomas, based on the inhibition of the oncogenic signal transduction pathways Pim-1 / STAT3 through RNA interference and miRNA replacement
(Applicants
Aigner, Achim
;
Kögel, Donat
)
P2-Rezeptorexpression und -funktion in noradrenergen und cholinergen sympathischen Neuronen
(Applicant
Allgaier, Clemens
)
Pathophysiological role of P2X7 receptors in the nervous system
(Applicant
Illes, Peter
)
Regulation and structure of TRPC4 and -5
(Applicant
Schaefer, Michael
)
Role of formins in tumor progression and metastasis in vivo
(Applicants
Aigner, Achim
;
Grosse, Robert
)
Role of purinergic signaling in acupunctureinduced analgesia
(Applicant
Illes, Peter
)
Signaltransduktionsmechanismen von G-Protein-gekoppelten Rezeptorkinasen
(Applicant
Lohse, Martin J.
)
The growth factor Pleiotrophin (PTN) and the PTN-receptor in testicular and colon carcinoma: functional analysis as a basis for gene therapy
(Applicant
Aigner, Achim
)
Therapeutic inhibition of peritoneal carcinomatosis by nanoparticle/siRNA-mediated knockdown of specific integrins and selectins
(Applicants
Aigner, Achim
;
Wicklein, Daniel
)
Therapie von Lungenmetastasen durch Einschleusung nanopartikulärer Komplexe zur Freisetzung bioaktiver RNA-Moleküle in Tumorzellen
(Applicant
Aigner, Achim
)
TRPA1 modulation by its lipid environment and physiological functions in skin-derived cells
(Applicant
Hill, Kerstin
)
Zusammenhang zwischen adaptiven Veränderungen im endogenen Belohnungssystem und klinisch relevanten Ernährungsstörungen
(Applicant
Kittner, Holger
)
Emmy Noether International Fellowships
Completed projects
Heterologe Expression und funktionale elektrophysiologische Charakterisierung eines Calciumkanals aus Spermatozoen
(Applicant
Hill, Kerstin
)
Research Units
Current projects
Development of novel nanoparticle formulations for therapeutic in vivo lncRNA knockdown and circRNA-mediated oncomiR inhibition
(Applicant
Aigner, Achim
)
FOR 5433: RNA in focus (RIF): From mechanisms to novel therapeutic strategies in cancer treatment
(Spokesperson
Hüttelmaier, Stefan
)
Completed projects
Characterization of affinity-tagged fluorescent P2X and P2Y receptors in BAC transgenic mice in health and disease
(Applicants
Franke, Heike
;
Schmalzing, Günther
)
Hormon-induzierte Differenzierung glatter Gefäßmuskelzellen
(Applicant
Reusch, Peter
)
Interfering with protein interaction of phosphoinositide-3-kinase gamma and of store-operated calcium channels
(Applicant
Schaefer, Michael
)
Involvement of P2 receptors in the modulation of nociceptive afferent stimuli
(Applicants
Illes, Peter
;
Riedel, Thomas
)
Pharmacological modulation of P2X receptors by approved drugs and natural compounds
(Applicant
Schaefer, Michael
)
Therapie pulmonaler Metastasen durch die Freisetzung von therapeutischen RNA-Molekülen aus polymeren Nanopartikeln
(Applicant
Aigner, Achim
)
Z-Project (coordination and central funds)
(Applicant
Schöneberg, Torsten
)
Collaborative Research Centres
Current projects
Mechanisms of receptor localization and localized signaling
(Project Heads
Bock, Andreas
;
Lohse, Martin J.
)
Structural dynamics of allosteric coupling in GPCRs
(Project Heads
Bock, Andreas
;
Coin, Irene
)
Completed projects
Aktivierung, Desensibilisierung und Internalisierung G-Protein-gekoppelter Rezeptoren
(Project Heads
Hoffmann, Carsten
;
Lohse, Martin J.
)
Assemblierung von TRPV-Untereinheiten zu funkionellen Kationenkanalkomplexen
(Project Heads
Schaefer, Michael
;
Schultz, Günter
)
Das ß-adrenerge Rezeptorsystem in der Herzinsuffizienz
(Project Head
Lohse, Martin J.
)
Desensibilisierung und Internalisierung G-Protein-gekoppelter Rezeptoren
(Project Heads
Krasel, Cornelius
;
Lohse, Martin J.
)
Intracellular cAMP- and cGMP-compartments in cell-cell communication in the cardiovascular system
(Project Head
Lohse, Martin J.
)
In vivo Detektion der Rezeptor-Signaltransduktion mittels FRET Mikroskopie
(Project Heads
Bünemann, Moritz
;
Lohse, Martin J.
)
Microscopic methods to study how GPCR dynamics and localization impact signaling specificity
(Project Heads
Annibale, Paolo
;
Lohse, Martin J.
)
Purinerge Neurotransmission
(Project Heads
von Kügelgen, Ivar Constantin
;
Nörenberg, Wolfgang
)
Regulatoren heterotrimerer G-Proteine
(Project Heads
Lohse, Martin J.
;
Quitterer, Ursula
)
Septale Neurone: Entwicklung präsynaptischer Funktionen
(Project Heads
Allgaier, Clemens
;
Heimrich, Bernd
;
Jackisch, Rolf
)
Sprecher, Sekretariat und Verwaltung des SFB
(Project Head
Lohse, Martin J.
)
Major Research Instrumentation
Completed projects
Zellanalyse- und Hochgeschwindigkeitssortiersystem
CRC/Transregios
Current projects
The role of TRPV2 and TRPV3 in epithelial barrier homeostasis
(Project Heads
Hill, Kerstin
;
Schaefer, Michael
)
Completed projects
Deciphering fast intra- and intermolecular dynamics of G protein-coupled receptors by Fluorescence (Cross) Correlation Spectroscopy
(Project Heads
Heinze, Katrin G.
;
Lohse, Martin J.
)
Growth regulation of small cell lung cancer cells by neuropeptides
(Project Heads
Aigner, Achim
;
Gudermann, Thomas
)
Kinetics of metabotropic glutamate receptors
(Project Heads
Benndorf, Klaus
;
Lohse, Martin J.
)
DFG Research Centres
Completed projects
Forschungsprofessuren
(Project Head
Lohse, Martin J.
)
FZT 82: Rudolf Virchow Center for Experimental Biomedicine
(Spokesperson
Lohse, Martin J.
)
Kernzentrum
(Project Head
Lohse, Martin J.
)
Nachwuchsgruppeninstitut
(Project Head
Lohse, Martin J.
)
Öffentlichkeitsarbeit
(Project Head
Lohse, Martin J.
)
Studiengänge
(Project Head
Lohse, Martin J.
)
Zentrale Verwaltung
(Project Head
Lohse, Martin J.
)
Research Training Groups
Completed projects
GRK 1097: Interdisciplinary Approaches in Cellular Neurosciences (InterNeuro)
(Spokesperson
Reichenbach, Andreas
)
Graduate Schools
Completed projects
GSC 106: Graduate School for Life Sciences (GSLS)
(Spokesperson
Kisker, Caroline
)
Additional Information
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