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Universitätsklinikum Erlangen AöR
Medizinische Klinik 4 - Nephrologie und Hypertensiologie

Address Ulmenweg 18
91054 Erlangen
Deutschland

GERiT This institution in GERiT

91054 Erlangen

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Prädisposition zu Organschäden bei Hypertonie
    (Applicant Hilgers, Karl Friedrich )
Clinical Research Units
- Completed projects
Independent Junior Research Groups
- Completed projects
  - Pathomechanismus der fokal-segmentalen Glomerulosklerose (FSGS): TGF-ß induzierte pro- und antiapoptotische Signaltransduktion in Podozyten
    (Applicant Schiffer, Mario )
Heisenberg Professorships
- Completed projects
  - Transplant Nephrology
    (Applicant Schiffer, Mario )
Research Units
- Current projects
  - FOR 5534: Fast Mapping of Quantitative MR-biosignatures at Ultra-high Magnetic Field
    (Spokesperson Nagel, Ph.D., Armin )
  - MR biosignatures of uremia-induced tissue alterations in patients with chronic kidney disease and hemodialysis patients
    (Applicant Dahlmann, Anke )
- Completed projects
  - Sodium as factor controlling the threshold of autoimmune arthritis
    (Applicant Herrmann, Martin )
Collaborative Research Centres
- Completed projects
  - Autokrine Faktoren in der glomerulären Entzündungsreaktion
    (Project Heads Schöcklmann, Harald O. ; Sterzel, Ralf Bernd )
  - Epigenetic identity and plasticity of renal tubular and interstitial cells
    (Project Head Schödel, Ph.D., Johannes )
  - Fibronectin and its role in polycystic kidney diseases
    (Project Heads Buchholz, Björn ; Tamm, Ernst R. )
  - HIF-prolylhydroxylases in the kidney: expression, regulation and effects of inhibition
    (Project Heads Eckardt, Kai-Uwe ; Willam, Carsten )
  - Mechanismen der Kontrolle und Regulation magnecellulärer Neurone des Hypothalamus der Ratte und ihre mögliche Bedeutung für die Schmerzverarbeitung
    (Project Heads Goppelt-Strübe, Margarete ; Swandulla, Dieter )
  - Molekulare Mechanismen der Fibroblastendifferenzierung als Ansatzpunkt für antifibrotische Therapie
    (Project Head Goppelt-Strübe, Margarete )
  - Pathogenesis of Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD)
    (Project Head Wiesener, Michael )
  - Protektive Wirkung von Interleukin-15-Fusionsproteinen durch Hemmung der Apoptose nach allogener Nierentransplantation
    (Project Heads Kunzendorf, Ulrich ; Tran, Thuong Hien )
  - Regulation of the internal electrolyte micromilieu by the immune system during homeostasis and inflammation
    (Project Heads Jantsch, Jonathan ; Titze, Jens Marc )
  - Role of oxidative Stress for the progression of diabetic nephropathy
    (Project Heads Schmieder, Roland E. ; Schneider, Markus )
  - Role of prolyl-hydroxylase domain enzyme inhibitors in chronic renal inflammation
    (Project Heads Jantsch, Jonathan ; Willam, Carsten )
  - Role of Protein Kinase C (PKC) - isoforms on TGF-ß/ glucose mediated podocyte signaling and apoptosis
    (Project Heads Haller, Hermann ; Schiffer, Mario )
  - Role of Renal Primary Sensory Neurons in Renal Inflammation and Sclerosis
    (Project Heads Tiegs, Gisa ; Veelken, Roland )
  - Slowing polycystic kidney disease by inhibition of HIF-1α-dependent- and calcium-mediated secretory signaling pathways
    (Project Head Buchholz, Björn )
  - The role of the antiapoptotic gene survivin in the kidney
    (Project Head Wiesener, Michael )
  - Zentrale Aufgaben
    (Project Head Schmieder, Roland E. )
CRC/Transregios
- Current projects
  - 3D-in-ovo-model to study and modulate the growth of human renal cystic tissue and mouse kidney slices
    (Project Heads Aung, Thiha ; Buchholz, Björn ; Härteis, Silke )
  - Anti-inflammatory and tissue-protective effects of 2-oxoglutarate-dependent dioxygenase inhibition in progressive kidney disease
    (Project Heads Jantsch, Jonathan ; Schley, Gunnar ; Willam, Carsten )
  - Biofabrication of a glomerular ex vivo model by stepwise mimicking functional core components
    (Project Heads Ahmad, Ph.D., Taufiq ; Müller-Deile, Janina )
  - Central Task
    (Project Heads Schiffer, Mario ; Warth, Richard )
  - Mechanisms of and interventional strategies against Autosomal Dominant Tubulointerstitial Kidney Diseases (ADTKD)
    (Project Head Wiesener, Michael )
  - Resolving glomerular to tubular crosstalk through miR-containing exosomes
    (Project Heads Müller-Deile, Janina ; Uderhardt, Stefan )
  - Role of renal dendritic cell subpopulations in the inflammatory environment of acute kidney injury and kidney transplantation
    (Project Heads Dudziak, Diana ; Hörning, Andre ; Willam, Carsten )
  - The epigenetic memory of renal tubular cells
    (Project Heads Grampp, Steffen ; Schödel, Ph.D., Johannes )
  - The impact of ROS, ferroptosis, glucose transport and IL-1 receptor signaling on the progression of ADPKD
    (Project Head Buchholz, Björn )
  - The role of Lipoprotein Receptor-Related Protein 1 (LRP1) in acute kidney injur
    (Project Heads Jobst-Schwan, Tilman ; Schiffer, Mario )
  - Tissue K+ and Na+ distribution in renal interstitial disease assessed by 39K and 23Na MRI
    (Project Heads Kopp, Christoph ; Nagel, Ph.D., Armin )
  - TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
    (Spokespersons Schiffer, Mario ; Warth, Richard )
Priority Programmes
- Completed projects
  - Bedeutung der mikrofibrillären Proteine Fibrillin-1, Emilin und Kollagen VI in der Verankerung der Basalmembran normaler und erkrankter Glomeruli (Role of microfibrillar proteins fibrillin-1, emilin and collagen type VI in basement membrane anchorage of normal and diseased glomeruli)
    (Applicant Sterzel, Ralf Bernd )
Research Training Groups
- Completed projects
  - GRK 750: Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics
    (Spokesperson Goppelt-Strübe, Margarete )

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