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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für Diagnostik
Institut für Immunologie
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Deciphering the pathomechanism of monogenic disorders associated with pathogenic variants in C20orf204, FBXW11 and WDHD1
(Applicant
Kutsche, Kerstin
)
Engineering the avidity of nanobody-based bispecific diabodies and heavy chain antibodies to specifically target myeloma cells that co-express two membrane proteins
(Applicants
Bannas, Peter
;
Koch-Nolte, Friedrich
)
iDfellows: Hamburg Clinician Scientist Programme in Infectious Diseases
(Applicant
Lohse, Ansgar W.
)
Impact of calcium and adenine nucleotide signaling on education and functionality of NK cells
(Applicants
Altfeld, Marcus
;
Diercks, Bjoern-Philipp
)
Metabolic determinants of HIV-1-associated pathogenesis
(Applicants
Altfeld, Marcus
;
Bunders, Ph.D., Madeleine
)
Regulation of immune cell populations and immune pathways by sex hormones
(Applicant
Altfeld, Marcus
)
Role of the Monocyte-Macrophage System in Early Life Cytomegalovirus infection
(Applicant
Stahl, Ph.D., Felix
)
Completed projects
Checkpoints in the thymus for the control of autoimmunity: Antigen processing and regulatory T-cells
(Applicant
Tolosa, Eva
)
Die Bedeutung von Ektoenzymen und purinergen Rezeptoren für die Regulation intestinaler T-Lymphozyten in Homöostase und Entzündung
(Applicant
Mittrücker, Hans-Willi
)
Einsatz neuer Immunisierungsstrategien zur Produktion von Kameliden Schwereketten-Antikörpern als Enzyminhibitoren
(Applicant
Koch-Nolte, Friedrich
)
Evaluation of P2X7 as a therapeutic target in autoimmune encephalomyelitis and in tumor immunity
(Applicant
Koch-Nolte, Friedrich
)
Fetale Ursache immunologischer Erkrankungen: Einfluss von mütterlichem Mikrochimärismus während der Schwangerschaft und dessen Modulation durch Stressbelastung
(Applicant
Arck, Petra Clara
)
Modulation of TCR signaling and synapse formation by ectoenzymes and purinergic signals under physiological and pathological conditions
(Applicant
Martin, Roland
)
Molecular and functional analyses of CD25 as a target for ADP-ribosylation on CD4+/CD25+ regulatory T cells
(Applicant
Koch-Nolte, Friedrich
)
Molecular mechanisms and functional consequences of P2X7 purinoceptor activation
(Applicant
Koch-Nolte, Friedrich
)
Molecular mechanisms and function of P2X7 ion channel gating on T cells
(Applicants
Koch-Nolte, Friedrich
;
Tolosa, Eva
)
Molekulare Klonierung und Charakterisierung humaner und muriner mono ADP-Ribosyltransferasen (Cholera- und Diphtherietoxinhomologe)
(Applicant
Koch-Nolte, Friedrich
)
Molekulare Mechanismen der NAD-induzierten T-Zell Apoptose und der funktionellen Regulation vom Membranproteinen durch ADP-Ribosylierung
(Applicant
Koch-Nolte, Friedrich
)
Nanobody-assisted structural and functional studies of the human ADP-ribosyltransferase ARTD4
(Applicant
Löw, Christian
)
Production of camelid heavy-chain antibodies as specific enzyme inhibitors using new immunization strategies
(Applicant
Koch-Nolte, Friedrich
)
The role of Interferon Regulatory Factor 4 in the regulation of T-cell memory
(Applicants
Mittrücker, Hans-Willi
;
Raczkowski, Friederike
)
The role of the nucleotide-gated cation channels P2X7 and TRPM2 for TCR signalling
(Applicants
Guse, Andreas H.
;
Haag, Friedrich
)
Clinical Research Units
Current projects
Exploring the cross-talk between bone and the immune system in early-onset low BMD disorders
(Applicant
Tolosa, Eva
)
KFO 5029: Precision Medicine for Early-Onset Low Bone Mineral Density Disorders
(Spokesperson
Amling, Michael
)
Completed projects
Congenital cytomegalovirus infection: identification of factors determining vertical transmission and clinical outcome of infected neonates
(Applicants
Brune, Wolfram
;
Stahl, Ph.D., Felix
)
Coordination Funds
(Applicant
Arck, Petra Clara
)
Coordination of the prospective pregnancy cohort PRINCE (Prenatal Identification of Children’s Health)
(Applicants
Diemert, Anke
;
Fehse, Boris
;
Hecher, Kurt
;
Muntau, Ania Carolina
;
Singer, Dominique
;
Stock, Philippe
;
Tolosa, Eva
;
Zapf, Antonia
)
Etablierung eines Maus-Infektionsmodells für das Bakterium Tropheryma whippelii
(Applicant
Mittrücker, Hans-Willi
)
Hormonal modulation of the Type I Interferon response during pregnancy: implications for maternal health and disease
(Applicant
Altfeld, Marcus
)
Influenza during pregnancy: The emergence of highly virulent H1N1 influenza virus strains and consequences for maternal and offspring’s health
(Applicants
Arck, Petra Clara
;
Gabriel, Gülsah
;
Mittrücker, Hans-Willi
)
Innate immune cells in the pathogenesis of PSC
(Applicants
Altfeld, Marcus
;
Herkel, Johannes
)
KFO 296: Feto-maternal immune cross talk: Consequences for maternal and offspring's health
(Spokesperson
Arck, Petra Clara
)
KFO 306: Primär Sklerosierende Cholangitis
(Spokesperson
Lohse, Ansgar W.
)
Mechanisms of prenatal glucocorticoid-induced changes on the offspring's immune system
(Applicant
Tolosa, Eva
)
Role of T cell subsets in anti-glomerular basement membrane glomerulonephritis
(Applicant
Mittrücker, Hans-Willi
)
Priority Programmes
Completed projects
Consequences of CTL-mediated immune pressure for HIV-1 capsid stability and innate sensing
(Applicant
Altfeld, Marcus
)
Research Units
Current projects
Coordination Funds
(Applicant
Altfeld, Marcus
)
FOR 2879: ImmunoStroke: From immune cells to stroke recovery
(Spokesperson
Liesz, Arthur
)
FOR 5068: Sex differences in immunity
(Spokesperson
Altfeld, Marcus
)
ImmunoStroke: From Immune Cells to Stroke Recovery Linking functional immune profiles and ischemic lesion characteristics in human stroke
(Applicants
Klotz, Luisa
;
Thomalla, Götz
;
Tolosa, Eva
;
Wiendl, Heinz
)
ImmunoStroke: From Immune Cells to Stroke Recovery The role of gasdermin D in ischemic stroke
(Applicants
Koch-Nolte, Friedrich
;
Magnus, Tim
)
Type I IFN-mediated sex differences in immune responses to HIV-1
(Applicant
Altfeld, Marcus
)
Collaborative Research Centres
Current projects
Adenine nucleotide-modulated T cell differentiation and effector functions
(Project Heads
Huber, Samuel
;
Mittrücker, Hans-Willi
)
Antibodies and nanobodies for adenine nucleotide research
(Project Heads
Haag, Friedrich
;
Koch-Nolte, Friedrich
;
Rissiek, Bjoern
)
Dissecting the cross talks between tissue resident memory T cells and kidney tissue
(Project Heads
Gagliani, Ph.D., Nicola
;
Mittrücker, Hans-Willi
)
Dissecting the role of ATP and adenosine receptor signaling for immune adaptation of intestinal Th17 cells
(Project Heads
Gagliani, Ph.D., Nicola
;
Tolosa, Eva
)
Humanizing purinergic signaling at the murine blood-brain barrier in
(Project Heads
Körbelin, Jakob
;
Magnus, Tim
;
Tolosa, Eva
)
Modulating immunity and inflammation via adenine nucleotides
(Project Heads
Gee, Ph.D., Christine Elizabeth
;
Koch-Nolte, Friedrich
;
Mittrücker, Hans-Willi
;
Tolosa, Eva
)
Purinergic receptors in adipose tissue inflammation and adaptive thermogenesis
(Project Heads
Heeren, Jörg
;
Koch-Nolte, Friedrich
)
Role of the ectonucleotidases CD39 and CD73 in immune responses to human viral infections
(Project Heads
Haag, Friedrich
;
Schulze zur Wiesch, Julian
)
Completed projects
Antigen-Präsentation im Thymus und Thymom: Pathogenetische Beziehungen zur Myastenia gravis
(Project Heads
Melms, Arthur
;
Tolosa, Eva
)
Bedeutung von Mono-ADP-Ribosyltransferasen für die Signalübermittlung im Immunsystem und die Pathogenese von Autoimmunerkrankungen
(Project Head
Koch-Nolte, Friedrich
)
Checkpoints in the thymus for the control of autoimmunity: Antigen proc-essing and regulatory T cells
(Project Heads
Melms, Arthur
;
Tolosa, Eva
)
HCV infection: Mechanisms of NK-cell-mediated control
(Project Head
Altfeld, Marcus
)
Mechanisms underlying and consequences of hepatic and intestinal manifestations of COVID-19
(Project Heads
Altfeld, Marcus
;
Huber, Samuel
)
Molecular mechanisms and functional consequences of ADAM protease activation induced by extracellular NAD or ATP
(Project Head
Koch-Nolte, Friedrich
)
Mukosale antigen-spezifische T-Lymphozytenantwort im Verlauf einer bakteriellen Infektion
(Project Heads
Kaufmann, Stefan H.E.
;
Mittrücker, Hans-Willi
)
Regulation of antibacterial immune responses in the liver
(Project Head
Mittrücker, Hans-Willi
)
Research Fellowships
Completed projects
Untersuchungen zur Rolle der natürlichen Killerzellen (NK) in der HIV-1 Infektion: Unterschiede in der NK Zellzahl, des Phänotyps und der Funktion in verschiedenen Stadien der Erkrankung sowie die Modulation der NK Zellfunktion durch Stimulation von Toll-like Rezeptoren
(Applicant
Meier, Angela
)
Research Training Groups
Completed projects
GRK 794: Cellular Mechanisms of Immune-Associated Processes
(Spokesperson
Rammensee, Hans-Georg
)
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