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Institution
Max-Planck-Institut für Immunbiologie und Epigenetik
Address
Stübeweg 51
79108 Freiburg
Deutschland
GERiT
This institution in GERiT
79108 Freiburg
Projects
Research Grants
Current projects
The role of the innate immune receptor MDA5 and inflammatory signaling in hematopoietic regeneration after chemotherapy.
(Applicant
Cabezas-Wallscheid, Nina
)
Completed projects
Comparative analysis of Su(var) chromatin regulators in Drosophila and the mouse
(Applicants
Jenuwein, Thomas
;
Reuter, Gunter
)
Molekulare Charakterisierung der lympho-epithelialen Interaktion im Thymus
(Applicant
Bleul, Conrad Christian
)
Penicilline als Inhibitoren von Interferon gamma
(Applicant
Weltzien, Hans Ulrich
)
The role of chromatin-associated heat-shock protein 90 in transcriptional response to stress
(Applicant
Sawarkar, Ph.D., Ritwick
)
Upstream and downstream signals of Ubc9 sumoylation
(Applicant
Pichler, Ph.D., Andrea
)
Vector-targeting CLP-vaccines against tick-transmitted infections
(Applicants
Nassal, Michael
;
Simon, Markus Michael
;
Wallich, Reinhard
)
Priority Programmes
Completed projects
Consequences of ubiquitin E2 enzyme (E2-25K) sumoylation
(Applicant
Pichler, Ph.D., Andrea
)
Identification of the most reprogramming-potent oocyte for more efficient cloning and for a long-term approach to the isolation of reprogramming factor(s)
(Applicant
Hiiragi, Takashi
)
Native display of Borrelia antigens on the surface of hepatitis B virus capsids: Improved prophylactic and potential therapeutic vaccines against Lyme disease
(Applicant
Simon, Markus Michael
)
Untersuchungen zu Modifikationen der primären Immunreaktionen durch Trypanosoma cruzi
(Applicant
Schaub, Günter Artur
)
Clinical Research Units
Completed projects
Part B: Signalling in Polycystic Kidney Disease: Wnt signalling in kidney development and disease
(Applicant
Grosschedl, Rudolf
)
Collaborative Research Centres
Current projects
Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape
(Project Heads
Cabezas-Wallscheid, Nina
;
Kierdorf, Katrin
)
SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
(Spokesperson
Meisinger, Chris
)
SFB 1425: Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications
(Spokesperson
Kohl, Peter
)
SFB 1453: Nephrogenetics (NephGen)
(Spokesperson
Köttgen, Anna
)
SFB 1479: Oncogene-driven immune escape (OncoEscape)
(Spokesperson
Zeiser, Robert
)
Completed projects
Analysis of pre-B cell receptor assembly and its SLP-65 dependent signalling function
(Project Head
Jumaa, Hassan
)
Control of functionality in the NF-êB system through association with cell-type specific co-factor complexes
(Project Head
Saccani, Simona
)
Cross-Talk Between the Heart and the Haematopoietic Niche in Post-Myocardial Infarction Lesion Remodelling
(Project Heads
Cabezas-Wallscheid, Nina
;
Heidt, Timo Sebastian
)
Deep-Sequencing / Bioinformatics
(Project Heads
Backofen, Rolf
;
Manke, Thomas
)
Die Rolle des Transkriptionsfaktors BOB.1 in der B-Zellentwicklung
(Project Heads
Nielsen, Ph.D., Peter
;
Reth, Michael
)
Epigenetic targeting of dormant leukemic stem cells
(Project Head
Cabezas-Wallscheid, Nina
)
Establishment of chromatin states in the early embryo
(Project Head
Iovino, Ph.D., Nicola
)
Exploring the Role of microRNAs in the Immune System
(Project Head
Fukao, Taro
)
Functional characterization of linker histone modifications and variants
(Project Head
Schneider, Robert
)
Funktionelle und strukturelle Beeinflussung des T-Zell Rezeptor/MHC-Komplexes durch MHC-assoziierte Peptide
(Project Head
Weltzien, Hans Ulrich
)
Genetische Analyse der Hypophysen-Entwicklung im Zebrafisch
(Project Head
Hammerschmidt, Matthias
)
Genetische Analyse der Thymusentwicklung bei Vertebraten
(Project Heads
Boehm, Thomas
;
Schorpp, Marcel
)
Induzierbare Immundefizienz mittels HIV-1-Nef
(Project Head
Niedermann, Gabriele
)
Integrated Research Training Group of Immunodeficiency (IRTG-IMM)
(Project Heads
Diefenbach, Andreas
;
Schamel, Wolfgang
)
Interaktion von MHC-Molekülen mit zellulären Proteinen und Adenovirus E3 Proteinen im Endoplasmatischen Retikulum
(Project Head
Burgert, Hans-Gerhard
)
In vivo Analyse von Protocadherin-ß Genen
(Project Head
Kemler, Rolf
)
Molecular basis of antigen recognition by variable lymphocyte receptors (VLRs)
(Project Head
Boehm, Thomas
)
Molecular mechanisms of thymus colonization: reconstruction of the thymic niche
(Project Head
Boehm, Thomas
)
Notch signalling in hematopoiesis: The role of RBP-Jk-assosiated transcriptional cofactors in lymphopoiesis
(Project Head
Borggrefe, Tilman
)
Production and analysis of B-cell mutant mice with the Cre/loxP method
(Project Head
Reth, Michael
)
Regulation of â-Catenin Function by NIP
(Project Head
Grosschedl, Rudolf
)
Regulation of neural stem cell maintenance and fate choice in the vertebrate brain through novel aspects of Notch signaling
(Project Head
Taylor, Ph.D., Verdon
)
Rekonstitution der Signalkaskaden vom B Zell Antigenrezeptor
(Project Head
Reth, Michael
)
Role of EBF transcription factors in normal and malignant lymphopoiesis
(Project Head
Grosschedl, Rudolf
)
Role of SUMOylation of Satb2 in the regulation of ES cell differentiation, gene expression and higher-order chromatin structure
(Project Head
Grosschedl, Rudolf
)
SFB 388: Cellular functions of dynamic protein interactions
(Spokesperson
Pfanner, Nikolaus
)
SFB 592: Signaling Mechanisms in Embryogenesis and Organogenesis
(Spokesperson
Driever, Wolfgang
)
SFB 620: Immunodeficiency: Clinical and Animal Models
(Spokesperson
Pircher, Hanspeter
)
SFB 746: Functional Specificity by Coupling and Modification of Proteins
(Spokesperson
Fakler, Bernd
)
SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
(Spokesperson
Peters, Christoph
)
SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
(Spokesperson
Schüle, Roland
)
Signalling pathways required for propagation and differentiation of thymic epithelial progenitor cells
(Project Head
Boehm, Thomas
)
Signalmechanismen bei der Segmentierung von Wirbeltieren
(Project Head
Herrmann, Bernhard G.
)
Somatic diversification of a transgenic TCR to enhance antiviral immunity and prevent immunopathology
(Project Head
Boehm, Thomas
)
Stochastic epigenetic control of obesity by Trim28
(Project Head
Pospisilik, Ph.D., John Andrew
)
Studying the molecular mechanisms underlying transcription regulation by the NSL complex.
(Project Head
Akhtar, Ph.D., Asifa
)
Targeting the stability of chromatin factors driving leukaemia
(Project Head
Sawarkar, Ph.D., Ritwick
)
The basic composition of mammalian heterochromatin
(Project Head
Jenuwein, Thomas
)
The role of histone acetyltransferase MOF in development and disease
(Project Head
Akhtar, Ph.D., Asifa
)
The role of SLP-65-induced FoxO transcription factors in B cell development
(Project Head
Jumaa, Hassan
)
The role of the cadherin switch compared to Zeb1-dependent EMT in embryogenesis and tumor formation
(Project Heads
Brabletz, Thomas
;
Stemmler, Marc
)
Untersuchung der frühesten Thymus-Einwanderer und ihrer Nische im Rhymus in der Maus als Grundlage des Verständnisses der Thymus-Repopulation nach myelo-ablativer Therapie im Menschen
(Project Head
Bleul, Conrad Christian
)
Wnt-dependent and Wnt-independent Regulation of Organogenesis by LEF1
(Project Head
Grosschedl, Rudolf
)
Research Fellowships
Completed projects
RhoA signalling as a potential tumour suppressor in medulloblastoma.
(Applicant
Herzog, Dominik
)
CRC/Transregios
Current projects
TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
(Spokesperson
Prinz, Marco
)
Completed projects
Role of Nuclear Matrix Attachment Regions for Gene Expression and Chromatin Accessibilty
(Project Head
Grosschedl, Rudolf
)
Research Training Groups
Current projects
GRK 2344: MeInBio - BioInMe: Exploration of spatio-temporal dynamics of gene regulation using high-throughput and high-resolution methods
(Spokesperson
Vogel, Tanja
)
Graduate Schools
Completed projects
GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED)
(Spokesperson
Borner, Christoph
)
Clusters of Excellence
Completed projects
EXC 294: Centre for Biological Signalling Studies (bioss) - From Analysis to Synthesis
(Spokesperson
Reth, Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2189: CIBSS - Centre for Integrative Biological Signalling Studies
(Spokespersons
Driever, Wolfgang
;
Hunte, Carola
;
Kleine-Vehn, Jürgen
;
Weber, Wilfried
)
Subinstitutions
Abteilung Chromatinregulierung
Abteilung Entwicklung des Immunsystems
Abteilung für Biologische Physik
Abteilung Immunmetabolismus
Abteilung Zelluläre und Molekulare Immunologie
Forschungsgruppe Hans-Spemann-Laboratorium (aufgelöst)
Labor Valérie Hilgers
Additional Information
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