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Institution

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Ruprecht-Karls-Universität Heidelberg
Pharmakologisches Institut

Address Im Neuenheimer Feld 366
69120 Heidelberg
Deutschland

GERiT This institution in GERiT

69120 Heidelberg

Projects

Research Grants
- Current projects
  - Development of new compounds to define the potential of TRPM4 inhibition for prevention and suppression of Ca2+ dependent cardiac arrhythmias.
    (Applicants Freichel, Marc ; Friese, Manuel A. ; Klein, Christian )
- Completed projects
Independent Junior Research Groups
- Completed projects
  - Molekulare Mechanismen synaptischer Plastizität bei chronischem Schmerz
    (Applicant Kuner, Rohini )
Clinical Research Units
- Completed projects
  - Molekulare Grundlagen der endogenen Hemmmechanismen gegen die Chronifizierung des Schmerzes
    (Applicant Kuner, Rohini )
  - Rolle von TRP-Kanälen beim kardialen Remodelling
    (Applicant Freichel, Marc )
Priority Programmes
- Completed projects
  - The role of TRPC1 C4 C5 C6 and related proteins for Ca2+ signaling in mast cells
    (Applicant Freichel, Marc )
Collaborative Research Centres
- Current projects
  - Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels
    (Project Heads Freichel, Marc ; Grimm, Christian Michael )
  - Cellular basis and mechanisms underlying the role of the prefrontal cortex in nociception and chronic pain
    (Project Head Kuner, Rohini )
  - Central Tasks
    (Project Head Kuner, Rohini )
  - Energy-metabolic interference as novel experimentaltherapeutic intervention for pathological forms of pain
    (Project Heads Bading, Hilmar ; Siemens, Jan )
  - Glial adrenergic receptors as targets for the treatment of neuropathic pain
    (Project Heads Agarwal, Ph.D., Amit ; Kirchhoff, Frank ; Kuner, Rohini ; Simonetti, Ph.D., Manuela )
  - Human pluripotent cell-derived neurons as a tool to study central and peripheral nociceptive mechanisms
    (Project Heads Acuna Goycolea, Ph.D., Claudio ; Schrenk-Siemens, Katrin )
  - Integrated Research Training Group for CardioScience
    (Project Head Freichel, Marc )
  - Interactions between nociceptive and non-nociceptive circuits: intranasal lidocaine to treat primary and secondary headache
    (Project Heads Carr, Richard ; Frings, Stephan ; Hu, Jing ; Lechner, Stefan ; Oehler, Beatrice )
  - Modulating oscillatory rhythms and their origins in GABAergic circuitry towards pain relief (human-rodent tandem)
    (Project Heads Kuner, Rohini ; Monyer, Hannah ; Ploner, Markus )
  - SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganisation
    (Spokesperson Kuner, Rohini )
  - Targeting Oat1 and Lrg1 in chronic pain
    (Project Heads Bading, Hilmar ; Mauceri, Daniela ; Ruiz de Almodovar Egea, Ph.D., Carmen ; Tappe-Theodor, Anke )
  - Unraveling molecular circuits leading to catecholamine-driven ventricular arrhythmias
    (Project Heads Freichel, Marc ; Levinson, Ph.D., Rebecca )
- Completed projects
  - Cavβ2- and Cavβ3-specific signal transduction
    (Project Heads Belkacemi, Anouar ; Flockerzi, Veit ; Philipp, Stephan E. )
  - Deletion and analysis of the function of calcium channels in mice
    (Project Head Freichel, Marc )
  - Functional roles and mechanisms of ROS-dependent sumoylation in diabetic neuropathy
    (Project Heads Agarwal, Nitin ; Kuner, Rohini )
  - Mechanisms underlying structural plasticity during memory consolidation in forebrain circuits
    (Project Heads Kuner, Rohini ; Kuner, Thomas )
  - Neuronal ensembles encoding distinct sensory modalities in the mouse somatosensory cortex
    (Project Head Kuner, Rohini )
  - Platform for CRISPR/Cas technology and AAV atherosclerosis model
    (Project Heads Freichel, Marc ; Medert, Rebekka ; Schumacher, Dagmar )
  - Semaphorin-plexin-B interactions in mechanisms go vering neuronal specification and connectivity
    (Project Head Kuner, Rohini )
  - Standardization and development of new pain-related models and methods in rodents and humans (human-rodent tandem)
    (Project Heads Tappe-Theodor, Anke ; Treede, Rolf-Detlef )
  - The membrane proteins TMEM1, 2 and 4
    (Project Head Freichel, Marc )
  - TRPC cation channels in hypoglycemia-associated autonomic nervous system failure in diabetes models
    (Project Head Freichel, Marc )
Major Research Instrumentation
- Completed projects
  - In vivo Multiphoton Imaging System
Research Units
- Completed projects
  - FOR 2289: Calcium homeostasis in neuroinflammation and -degeneration: New targets for therapy of multiple sclerosis?
    (Spokesperson Diem, Ricarda )
  - Neuronal intracellular Ca2+ stores in inflammatory neurodegeneration.
    (Applicants Freichel, Marc ; Friese, Manuel A. )
CRC/Transregios
- Current projects
  - Functional and molecular specificity of OCaR-control of intracellular Ca2+ release
    (Project Heads Freichel, Marc ; Schulte, Uwe )
  - The role of TRP channels in heat acclimation
    (Project Head Siemens, Jan )
International Research Training Groups
- Completed projects
  - GRK 1874: Diabetic Microvascular Complications (DIAMICOM)
    (Spokesperson Hammes, Hans-Peter )
Clusters of Excellence
- Completed projects
  - EXC 81: Cellular Networks: From Analysis of Molecular Mechanisms to a Quantitative Understanding of Complex Functions (CellNetworks)
    (Spokesperson Kräusslich, Hans-Georg )
Graduate Schools
- Completed projects
  - GSC 249: The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
    (Spokesperson Wittbrodt, Joachim )

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