SFB 1292:  Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections

• Subject Area: Medicine ; Biology
• Term: since 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• 01 - Understanding the molecular mechanisms of polyamines in regulating regulatory T cell functional polarization in chronic infections and in tumors (Project Head Bopp, Tobias )
• 02 - TF-PAR signaling in viral infections (Project Heads Beling, Antje ;  Ruf, Wolfram )
• 05 - Signaling mechanisms regulating anti-tumor immunity and viral pathogenesis (Project Heads Ciesek, Sandra ;  Rajalingam, Krishnaraj )
• 08 - Mechanism and modulation of organ-specific therapy responses in metastatic melanoma (Project Heads Deppermann, Carsten ;  Kramer, Daniela ;  Schuppan, Detlef )
• 09 - Modulation of glioma-neuron networks by immune cells in malignant brain tumors (Project Heads Schmidt, Mirko H.H. ;  Zipp, Frauke )
• 10 - Elucidating the interplay between coagulation and pH in modulating antitumor immunity (Project Heads Graf, Ph.D., Claudine ;  Munir, Hafsa ;  Ruf, Wolfram )
• 11 - Transcriptional regulation and interactomes of viral immune evasion proteins (Project Heads Distler, Ute ;  Lemmermann, Niels ;  Reddehase, Matthias J. )
• 12 - Edited CAR effector cell therapy targeting adaptive resistance to therapeutic Menin-KMT2A chromatin complex disruption in leukemia (Project Heads Fulda, Simone ;  Kühn, Michael ;  Ullrich, Evelyn )
• 13 - Tonic type I interferon induction by the human gut microbiota and its role in infection and cancer (Project Heads Probst, Hans Christian ;  Schild, Hansjörg ;  Vieira-Silva, Ph.D., Sara )
• 15 - The crosstalk between B cells and myeloid cells during viral and parasitic infection (Project Heads von Stebut, Esther ;  Waisman, Ari )
• 16 - Reg3-mediated mechanisms in control of UPR and anti-tumor immunity (Project Heads Greten, Florian R. ;  Hövelmeyer, Nadine )
• 17 - Identification of blood circulating dietary nutrients to empower anti-tumor neoepitope specific TCR T cells (Project Heads Kreiter, Sebastian ;  Sahin, Ugur ;  Vascotto, Fulvia )
• 18 - Harnessing Metabolic Modulation of Tregs and Dendritic Cells to Enhance Immunotherapy Efficacy (Project Heads Berod, Ph.D., Luciana ;  Sparwasser, Tim Dominik )
• 19 - Controlling the suppressive and regeneration programs in tumor-resident tissue Treg cells (Project Heads Delacher, Michael ;  Marini, Federico )
• 21 - Synergizing Immune Effectors and Transcriptional Modulation for Enhanced Type-I Interferon Therapy in MPNs (Project Heads Muth, Sabine ;  Radsak, Markus P. ;  Sasca, Daniel )
• 22 - (Re)installing Cancer Immunity in Pancreatic Cancer and Cancers of the Upper GI Tract (Project Heads Gaida, Matthias ;  Türeci, Özlem )
• 24 - Impact of MHC-I Ligandome Quality Control on the adaptive immune response in cancer and chronic infection (Project Heads Dikic, Ivan ;  Schild, Hansjörg )
• 26 - The role of subcellular GPR65 signaling in immune cell function (Project Heads Bock, Andreas ;  Bohn, Toszka )
• IRTGMGK - Integrated Research Training Group (IRTG) (Project Heads Bopp, Tobias ;  Clausen, Björn ;  Hövelmeyer, Nadine ;  Kühn, Michael )
• Q01 - Integrated OMICS, Bioinformatics and Morpho-molecular Immunomonitoring Unit (Project Heads Albrecht, Christian ;  Bukur, Valesca ;  Gaida, Matthias ;  Imbusch, Charles ;  Tenzer, Stefan )
• Z02 - Central Task (Project Heads Bopp, Tobias ;  Schild, Hansjörg )

Completed projects

• 04 - Regulation of SAMHD1: impact on inflammation, viral replication and malignant diseases (Project Head König, Renate )
• 06 - Molecular T cell immunotherapy and inhibition of tumor immune escape mechanisms (Project Heads Munder, Markus ;  Theobald, Matthias )
• 07 - Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion (Project Heads Marquardt, Jens U. ;  Strand, Susanne )
• 14 - Immunmodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells (Project Heads Clausen, Björn ;  Holtappels, Rafaela )
• 20 - Mechanisms of IL-10 mediated tumor immune evasion in colorectal cancer development (Project Heads Clausen, Björn ;  Hövelmeyer, Nadine )

• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Participating Institution: Georg-Speyer-Haus; Institut für Tumorbiologie und experimentelle Therapie; Deutsches Krebsforschungszentrum (DKFZ); Helmholtz-Institut für Translationale Onkologie Mainz (HI-TRON Mainz)
• Participating University: Charité - Universitätsmedizin Berlin; Goethe-Universität Frankfurt am Main; Universitätsklinikum Köln; Klinik für Dermatologie und Venerologie; Rheinische Friedrich-Wilhelms-Universität Bonn; Technische Universität Dresden
• Spokespersons: Professor Dr. Tobias Bopp; Professor Dr. Hansjörg Schild, until 12/2025