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Institution

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Universitätsklinikum Freiburg
Neurozentrum
Institut für Neuropathologie

Address Breisacher Straße 64
79106 Freiburg
Deutschland

GERiT This institution in GERiT

79106 Freiburg

Projects

Research Grants
- Current projects
  - Autophagy in Microglia-mediated De- and Re-myelination
    (Applicant Lünemann, Jan )
  - Deciphering the History and Diversity of White and Grey Matter Microglia in Neurodegeneration and Aging
    (Applicants Gökçe, Özgün ; Prinz, Marco ; Simons, Mikael Jakob )
  - Macrophage diversity: nature vs. nurture
    (Applicant Kierdorf, Katrin )
- Completed projects
Priority Programmes
- Completed projects
  - Analysis of the ISG15 conjugation and deconjugation system in vivo
    (Applicant Knobeloch, Klaus-Peter )
Research Units
- Completed projects
  - Coordinating Project
    (Applicant Prinz, Marco )
  - FOR 1336: From Monocytes to Brain Macrophages - Conditions Influencing the Fate of Myeloid Cells in the Brain
    (Spokespersons Priller, Josef ; Prinz, Marco )
  - Role of the Transcription Factor IRF-8 for Microglia Homeostasis and Function
    (Applicant Prinz, Marco )
Reinhart Koselleck Projects
- Completed projects
  - Identification of factors regulating fate and function of microglia and macrophages in the CNS.
    (Applicant Prinz, Marco )
Collaborative Research Centres
- Current projects
- Completed projects
  - Bedeutung des Zytochrom P450-Monooxygenasesystems für die neuronale Differenzierung
    (Project Head Volk, Benedikt )
  - New faces of type I interferons: from immunosuppression to tissue homeostasis
    (Project Head Prinz, Marco )
  - Wirkungen von Zytokinen auf das Zentralnervensystem
    (Project Head Volk, Benedikt )
Major Research Instrumentation
- Completed projects
CRC/Transregios
- Current projects
  - Central Tasks of the Collaborative Research Centre
    (Project Head Prinz, Marco )
  - CoPILOT, PILOT’s Integrated Research Training Group
    (Project Heads Kierdorf, Katrin ; Sperandio, Markus )
  - Deciphering molecular recruitment mechanisms of microglial progenitors during development
    (Project Head Kierdorf, Katrin )
  - Definition of context-specific microglia states and the pathways involved by single-cell profiling
    (Project Head Prinz, Marco )
  - How the gut microbiota controls CNS macrophages during aging and age-related neurodegenerative diseases
    (Project Heads Blank, Thomas ; Erny, Daniel )
  - Perinatal crosstalk of microbiota and intestinal macrophages in the control of mucosal pathogens
    (Project Heads Clavel, Thomas ; Erny, Daniel ; Henneke, Philipp )
  - Perinatal fate decisions of macrophages in protected tissues
    (Project Head Prinz, Marco )
  - Role of crosstalk between γδ T cells and Langerhans cells in driving their mutual differentiation in the postnatal niche
    (Project Heads Kierdorf, Katrin ; Sagar, Sagar )
  - The NLRP3 inflammasome in CNS homeostasis and disease
    (Project Head Groß, Olaf )
  - TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
    (Spokesperson Prinz, Marco )
  - USP18 as a key regulator for microglia activation
    (Project Heads Beling, Antje ; Knobeloch, Klaus-Peter )
- Completed projects
  - Differential roles of resident microglia and myeloid cells in neuroinflammatory conditions
    (Project Heads Priller, Josef ; Prinz, Marco )
Research Fellowships
- Completed projects
  - Development of cmyb-independent macrophages from the primitive hematopoiesis
    (Applicant Kierdorf, Katrin )
Research Training Groups
- Current projects
  - GRK 2606: Understanding protease functions in cellular pathways through discovery and analysis of protease substrates (ProtPath)
    (Spokesperson Reinheckel, Thomas )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2189: CIBSS - Centre for Integrative Biological Signalling Studies
    (Spokespersons Driever, Wolfgang ; Hunte, Carola ; Kleine-Vehn, Jürgen ; Weber, Wilfried )

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