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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Institut für Immunologie
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Grants
Current projects
Characterization of molecular mechanisms of metabolic bariatric surgery on microbiome, bile acid, and lipid metabolism for targeted therapeutic intervention in patients with fatty liver disease.
(Applicants
Tenzer, Stefan
;
Teufel, Ph.D., Andreas
)
Modifying macrophage polarization to improve cancer immunotherapies
(Applicants
Alflen, Astrid
;
Bohn, Toszka
)
Role of T-cell derived prothrombin in septicemia
(Applicants
Danckwardt, Sven
;
Probst, Hans Christian
)
Completed projects
Alternative splicing as an element of signal transduction in multi-step phosphorelay systems of fungi
(Applicants
Jacob, Stefan
;
Tenzer, Stefan
)
Analysis of the mechanisms involved in functional impairment of cytotoxic T cells during chronic viral infection
(Applicant
Probst, Hans Christian
)
Comparative studies on the regulation of the production of the asthma-inducing cytokin Interleukin 9 (IL-9) in primary murine mast cells and T-cells
(Applicant
Schmitt, Edgar
)
Deciphering the role of the IRF4 interactome in differentiating regulatory T and T helper 17 cells in health and autoimmune disease
(Applicants
Bopp, Tobias
;
Distler, Ute
)
Die kutane Mastzelle als potenter Initiator entzündlicher Reaktionen
(Applicant
Stassen, Michael
)
Effect of tick saliva cystatins on Th9 cells, mast cells and the development of experimental asthma
(Applicant
Schmitt, Edgar
)
Identification and characterization of L. major T cell epitopes based on quantitative proteomics
(Applicants
von Stebut, Esther
;
Tenzer, Stefan
)
Polyphosphates as Novel Pathogen-Associated Molecular Patterns in Macrophages
(Applicant
Bosmann, Markus
)
The role of TREM-1 and it´s ligand in regulating the innate immune response
(Applicant
Radsak, Markus P.
)
Transcriptional Regulation in Murine Regulatory T Cells and Suppressed CD4+ T Cells: Identification and Functional Analyses
(Applicants
Bopp, Tobias
;
Schmitt, Edgar
)
Wheat sensitivity: Impact of wheat varieties and wheat growing conditions on innate immunity
(Applicants
Longin, Friedrich
;
Schuppan, Detlef
;
Tenzer, Stefan
)
Priority Programmes
Completed projects
Activation mechanisms by TREM-1 and it´s significance in immunomodulation post trauma
(Applicant
Radsak, Markus P.
)
Functional characterization of cell-specific differences of L. major-containing phagolysosomes in macrophages and dendritic cells
(Applicants
von Stebut, Esther
;
Tenzer, Stefan
)
Integrated Proteomics and Lipidomics Platform
(Applicants
Bindila, Ph.D., Laura
;
Distler, Ute
)
Interactions between mast cells and neutrophils in murine models of acute inflammation
(Applicant
Stassen, Michael
)
Mast cells as inducers and modulators of adaptive immune responses
(Applicant
Stassen, Michael
)
Rapid adaptation of signaling networks in the fungal Pathogen Magnaporthe oryzae
(Applicants
Jacob, Stefan
;
Tenzer, Stefan
)
Spezifität und Mechanismus des eukaryotischen 20S/26S Proteasoms (Specificity and mechanism of the eukaryotic 20S/26S proteasome)
(Applicant
Schild, Hansjörg
)
Thiol switches controlled by the glutathione-S-transferase GDAP1
(Applicants
Methner, Axel
;
Tenzer, Stefan
)
Collaborative Research Centres
Current projects
Central Task
(Project Head
Schild, Hansjörg
)
Induction of a tissue repair program as a strategy for immune evasion in tumors and chronic infections
(Project Heads
Delacher, Michael
;
Marini, Federico
)
Integrated OMICS, Bioinformatics and Morpho-molecular Immunomonitoring Unit
(Project Heads
Albrecht, Christian
;
Bukur, Valesca
;
Gaida, Matthias
;
Tenzer, Stefan
)
Integrated Research Training Group
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
Microbiota induced tonic type I interferons in the control of CTL responses to cancer, chronic and acute virus infections
(Project Heads
Probst, Hans Christian
;
Schild, Hansjörg
)
Neo-epitope specific CD4+ T cells – Anti-tumoral mechanisms and their modulation
(Project Heads
Kreiter, Sebastian
;
Sahin, Ugur
)
Regulation and host targets of viral immune evasion
(Project Heads
Distler, Ute
;
Lemmermann, Niels
;
Reddehase, Matthias J.
)
SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
(Spokesperson
Schild, Hansjörg
)
T cell recognition and immune editing in SCLC
(Project Heads
Kolb, Ph.D., Laura
;
Sahin, Ugur
)
Type-I Interferons – a double-edged sword in Myeloproliferative Neoplasms and Chronic Viral Infections
(Project Heads
Muth, Sabine
;
Radsak, Markus P.
)
Understanding the role of GPCR65-dependent metabolic communication in the tumor microenvironment
(Project Heads
Bopp, Tobias
;
Schmitt, Edgar
)
Completed projects
Development and testing of nanoparticles to eliminate the cAMP-mediated immune-suppression in the malignant melanoma
(Project Heads
Barz, Matthias
;
Becker, Christian
;
Bopp, Tobias
)
Entwicklung RNS basierter Impfstoffe zur Induktion integrierter T und B-Zellimmunantworten gegen molekular definierte Tumorantigene
(Project Head
Sahin, Ugur
)
Evaluation of systemic mRNA/peptide-based nanoparticle vaccines in melanoma tumor models
(Project Heads
Diken, Mustafa
;
Schild, Hansjörg
)
From nanomaterial surface to function - multifunctional PEGylation, targeting and in vivo proteomics
(Project Heads
Frey, Holger
;
Mailänder, Volker
;
Tenzer, Stefan
)
Isolierung und Charakterisierung muriner CD25+ T-regulatorischer Zellen und funktionelle Analyse ihrer suppressiven Wirkung auf konventionelle T-Zellen und Th2-Zellen
(Project Head
Schmitt, Edgar
)
Massenspektrometrie
(Project Head
Tenzer, Stefan
)
Molecular interactions during MHC class I-restricted antigen processing
(Project Heads
Schild, Hansjörg
;
Tenzer, Stefan
)
Molekulare Interaktionen bei der MHC-Klasse-I-restringierten Antigenprozessierung
(Project Head
Schild, Hansjörg
)
Molekulare Interaktionen bei der MHC-Klasse-I-restringierten Antigenprozessierung
(Project Head
Schild, Hansjörg
)
Multifunctional nanosized peptide/glycopeptide conjugates as fully-synthetic vaccine for tumor-immunotherapy
(Project Heads
Besenius, Pol
;
Bopp, Tobias
;
Schmitt, Edgar
)
Nano-particular mRNA-carrier systems to reprogram different immune-cell populations
(Project Heads
Barz, Matthias
;
Langguth, Peter
;
Sahin, Ugur
)
Phagozytose-induzierte Antigenprozessierung in prädifferenzierten dendritischen Zellen aus Zytokin-gesteuerten Knochenmarkkulturen
(Project Head
Reske, Konrad
)
Polymer-mediated tumor immunotherapy via in situ activation of antigen-presenting cells
(Project Heads
Grabbe, Stephan
;
Nuhn, Ph.D., Lutz
;
Schild, Hansjörg
)
Proteins on nanocarriers: from the stealth effect to active targeting in vivo
(Project Heads
Mailänder, Volker
;
Tenzer, Stefan
;
Weil, Tanja
)
Regulation der Adhäsion von Tumorzellen durch extra- und intrazelluläre Liganden von E-Selektin
(Project Heads
Dippold, Wolfgang
;
Schmitt, Edgar
)
Removal of the acidosis-dependent immune evasion mechanism of the malignant melanoma using pH modulating nanocarrier
(Project Heads
Bohn, Toszka
;
Miederer, Ph.D., Matthias
;
Weil, Tanja
)
Selektion und Transfer therapeutischer T-Zellrezeptoren
(Project Heads
Schild, Hansjörg
;
Theobald, Matthias
;
Voss, Ralf-Holger
)
Spezifische Aspekte der Cytokinproduktion von Mastzellen und die Bedeutung von Mastzellen und ihren Produkten während der Sensibilisierung und Manifestation des atopischen Asthma
(Project Head
Stassen, Michael
)
Targeted inflammation - improving migration of leucocytes to the tumor through polymer-assisted activating of tumor endothelial tissue
(Project Heads
Sahin, Ugur
;
Schmitt, Edgar
)
Tumorabstoßung durch zytotoxische T-Zellen in vivo: Einfluß von Toll-like Rezeptor vermittelten Signalen
(Project Heads
Radsak, Markus P.
;
Schild, Hansjörg
)
Umfassende Analyse molekular und immunologisch definierter Alterationen beim Bronchialkarzinom
(Project Head
Sahin, Ugur
)
Clinical Research Units
Completed projects
Modulation von Graft-versus-Host und Graft-versus-Tumor Reaktionen durch regulatorische T-Zellen
(Applicant
Radsak, Markus P.
)
CRC/Transregios
Current projects
CK2 as a Molecular Switch Regulating Immunity and Tolerance by APC-dependent Induction of Treg cells
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
Control of cytotoxic T cell responses in the skin by mononuclear phagocytes during primary viral infection and memory recall
(Project Heads
Probst, Hans Christian
;
Schild, Hansjörg
)
Dynamics, epigenetic signatures and modulating factors of tissue Treg cell differentiation
(Project Heads
Delacher, Michael
;
Hühn, Jochen
)
In situ reprogramming of dendritic cells for immunomodulation of CNS-specific Foxp3+ regulatory T cells
(Project Heads
Sahin, Ugur
;
Waisman, Ari
)
Myeloid cell–regulatory T cell crosstalk in thrombus development and resolution
(Project Heads
Bopp, Tobias
;
Ruf, Wolfram
)
The role of CD18 and regulatory T cells in skin inflammation
(Project Heads
Bopp, Tobias
;
Grabbe, Stephan
)
Treg Commons
(Project Heads
Delacher, Michael
;
Schubert, Benjamin
)
Completed projects
Central Tasks of the Collaborative Research Centre/Secretariat
(Project Head
Schmitt, Edgar
)
Functional Characterization of New Regulatory RUNX1 (AML1) Isoforms in T Cells
(Project Heads
Gattenlöhner, Stefan
;
Schmitt, Edgar
)
Transcription Factors of Murine Regulatory T Cells and Suppressed CD4+ T Cells: Identification and Functional Analyses
(Project Heads
Bopp, Tobias
;
Schmitt, Edgar
)
Transcutaneous immunization: Mechanisms of intercellular crosstalk in the skin
(Project Heads
Radsak, Markus P.
;
Stassen, Michael
)
TRR 52: Transcriptional Programming of Individual T Cell Subsets
(Spokesperson
Schmitt, Edgar
)
Unraveling the role of myeloid cells and metabolism in clinical progression of MS
(Project Heads
Bittner, Stefan
;
Bopp, Tobias
;
Zipp, Frauke
)
Major Research Instrumentation
Completed projects
5-Laser Cell Sorter with Imaging Function
Hochauflösende Elektrospray-Ionisations Hybrid-Massenspektrometer Plattform
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
Additional Information
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