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Project Details

Institution

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Universitätsklinikum Bonn (AöR)
Medizinische Fakultät
Institut für Angeborene Immunität

Address Venusberg-Campus 1
53127 Bonn
Deutschland

GERiT This institution in GERiT

53127 Bonn

Projects

Emmy Noether Independent Junior Research Groups
- Completed projects
  - Elucidating inflammasome activation with alpaca single domain antibodies
    (Applicant Schmidt, Florian Ingo )
Priority Programmes
- Completed projects
WBP Position
- Current projects
  - The role of renal macrophage-epithelial cell interactions in promoting polycystic kidney disease (PKD) progression
    (Applicant Gonilski Pacin, Ph.D., David Nicolas )
Major Research Instrumentation
- Completed projects
Clinical Research Units
- Completed projects
  - Inflammasome activiation in Alzheimer´s disease
    (Applicant Latz, Eicke )
Collaborative Research Centres
- Current projects
  - ATP Citrate Lyase (ACLY)-mediated macrophage reprogramming in metaflammation
    (Project Heads Hiller, Karsten ; Latz, Eicke )
  - Central Tasks of the Collaborative Research Centre
    (Project Heads Latz, Eicke ; Wachten, Dagmar )
  - Impact of metaflammation on hepatic macrophage function in tissue regeneration
    (Project Heads Abdullah, Zeinab ; Meissner, Felix )
  - Molecular pathways of gasdermin pore formation and repair
    (Project Heads Latz, Eicke ; Schmidt, Florian Ingo )
  - Multi-omics – Technology and strategic support
    (Project Heads Hiller, Karsten ; Meissner, Felix ; Thiele, Christoph )
  - NLRP10 inflammasome mediated anti-inflammatory cell death
    (Project Head Latz, Eicke )
  - Preventive interventions in unhealthy nutritional behaviours
    (Project Heads Albrecht, Clemens ; Christ, Anette ; Lemken, Dominic ; von Stetten, Moritz )
  - Proteomic dissection of cell death-mediated protein release and proteolysis
    (Project Heads Huesgen, Pitter ; Meissner, Felix )
  - S14 Sphingomyelin induced neuro-immune reprogramming during metaflammation
    (Project Heads Düwell, Peter ; Latz, Eicke ; McManus, Róisín )
  - SFB 1454: Metaflammation and Cellular Programming
    (Spokespersons Latz, Eicke ; Wachten, Dagmar )
- Completed projects
  - Dissecting the communication between immune and tumor cells with quantitative proteomics
    (Project Head Meissner, Felix )
  - Extracellular functions of inflammasomes
    (Project Head Latz, Eicke )
  - Functional proteomics dissection of chemotactic protein diversity
    (Project Head Meissner, Felix )
  - Imaging-unit
    (Project Heads Büning, Hildegard ; Kashkar, Hamid ; Latz, Eicke ; Protzer, Ulrike ; Schauss, Astrid ; Utermöhlen, Olaf )
  - Inflammatory pathways in subtypes of intestinal cancer
    (Project Heads Meissner, Felix ; Saur, Dieter )
  - Mechanisms of microbiota-mediated alteration in atherogenesis
    (Project Heads Düwell, Peter ; Latz, Eicke ; Schnurr, Maximilian )
  - Proteomics identification of macrophage-derived signals impacting metaflammation in tissues
    (Project Head Meissner, Felix )
  - Rage signalling and function in lung immunity
    (Project Head Latz, Eicke )
  - Regulation of innate immune activation by high density lipoproteins
    (Project Head Latz, Eicke )
CRC/Transregios
- Current projects
  - Biomarkers and mechanisms of disease progression and outcome in aortic stenosis in humans
    (Project Heads Franklin, Bernardo ; Luetkens, Julian Alexander ; Mauri, Victor ; Shamekhi, Jasmin ; Veulemans, Ph.D., Verena ; Zeus, Tobias )
  - Danger signalling pathways in aortic disease
    (Project Heads Latz, Eicke ; Zimmer, Sebastian )
  - Functional Proteomics/Metabolomics/Lipidomics and Human Adipocyte Unit
    (Project Heads Dyar, Ph.D., Kenneth A. ; Meissner, Felix ; Pfeifer, Alexander )
  - Role of UNC93B1 in nucleic acid-sensing TLR function - relevance for the pathogenesis of systemic lupus erythematosus
    (Project Heads Latz, Eicke ; Lee-Kirsch, Min Ae )
  - Systematic dissection of cytosolic DNA sensing and signalling with nanobodies and proteomics
    (Project Heads Hartmann, Gunther ; Meissner, Felix ; Schmidt, Florian Ingo )
  - The CD40/CD40L-axis in aortic aneurysm: defining immune cell interactions and therapeutic targets
    (Project Heads Gerdes, Norbert ; Lutgens, Esther ; Schmidt, Susanne )
  - Transcriptomics and epigenetic data analysis
    (Project Heads Billmann, Maximilian ; Schmidt, Susanne )
- Completed projects
  - Functional proteomics dissection of phagocyte derived signals during CNS inflammation and recovery
    (Project Head Meissner, Felix )
  - Histopathological platform for analysis of hepatic and renal fibrosis
    (Project Heads Boor, Ph.D., Peter ; Fischer, Hans-Peter ; Franklin, Bernardo ; Kristiansen, Glen ; Longerich, Thomas )
  - Molecular dissection of anti-inflammatory effects of HDL
    (Project Head Latz, Eicke )
  - Role of inflammasome activation in lupus nephritis
    (Project Heads Latz, Eicke ; Ludwig-Portugall, Isis )
Research Grants
- Current projects
- Completed projects
  - Identification and characterization of the mechanisms and relevance of inflammasome activation in mast cells
    (Applicant Maurer, Marcus )
  - Indolamin-2,3-Dioxigenase (IDO) induction in T cells as new mechanism of tumor-induced immunosuppression in pancreatic carcinoma
    (Applicants Düwell, Peter ; Schnurr, Maximilian )
WBP Fellowship
- Current projects
  - The influence of regular physical activity on leukocyte production
    (Applicant Nickenig, Maximilian )
DIP Programme
- Current projects
  - Elucidating the roles of the NLRPlO inflammasome in regulating malignancy and autoimmunity
    (Applicants Elinav, Eran ; Latz, Eicke )
International Research Training Groups
- Completed projects
  - GRK 2168: Myeloid antigen presenting cells and the induction of adaptive immunity
    (Spokesperson Kurts, Christian )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2151: ImmunoSensation3 - the immune sensory system: from Immune Diversity to precision medicine
    (Spokespersons Hartmann, Gunther ; Schlitzer, Andreas ; Schneider, Anja )
  - EXC 3118: ImmunoPreCept: Exploring the Health-Disease Bifurcation for Cell-based Molecular Prevention and Interceptive Medicine
    (Spokespersons Diefenbach, Andreas ; Rajewsky, Nikolaus ; Siegmund, Britta )
Clusters of Excellence
- Completed projects
  - EXC 1023: ImmunoSensation: The Immune Sensory System
    (Spokesperson Hartmann, Gunther )
NFDI technical and methodological consortia
- Current projects
  - National Research Data Infrastructure for Immunology
    (Spokesperson Busse, Christian )

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