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Institution
Universitätsklinikum Schleswig-Holstein
Campus Kiel
Institut für Immunologie
Address
Arnold-Heller-Straße 3
24105 Kiel
Deutschland
GERiT
This institution in GERiT
24105 Kiel
Projects
Research Grants
Current projects
Memory T and B cells in the lung and their role for local and systemic immunity
(Applicant
Hutloff, Andreas
)
Plasticity of human gamma/delta T cells: Modulation by Vitamin C
(Applicant
Kabelitz, Dietrich
)
Quantitative analysis of early follicular helper T cell development using spatiotemporal modeling and in vivo mouse models
(Applicants
Hutloff, Andreas
;
Thurley, Kevin
)
Completed projects
Analyse der Potenz von Fibroblastenwachstumsfaktoren (bFGF) und bone morphogenetic protein 2 sowie von Expressionsplasmiden dieser Faktoren in der Behandlung der Osteoradionekrose
(Applicant
Springer, Ingo
)
A pathogen-specific CD4 T cell atlas for chronic inflammatory diseases
(Applicants
Bacher, Petra
;
Franke, Andre
;
Scheffold, Alexander
)
Chemokinvermittelte Transmigration durch das Sinusendothel der Leber: molekulare Mechanismen und therapeutische Zielstrukturen bei hepatischer Entzündung
(Applicant
Scheffold, Alexander
)
Das M. tuberculosis-Phagosom: Dynamik der erregerinduzierten Modulation intrazellulärer Grenzflächen
(Applicants
Reiling, Norbert
;
Schütze, Stefan
)
Dissection of cell-cell communication networks in chronic viral infection by kinetic immune-cell monitoring and mathematical modeling
(Applicants
Löhning, Max
;
Thurley, Kevin
)
Dissection of TRAIL-mediated signaling in pancreatic ductal adenocarcinoma cells - towards efficient anti-tumor therapy
(Applicant
Trauzold, Anna
)
Funktionelle Bedeutung der Internalisierung des CD95/Fas-Rezeptors für pro- und nichtapoptotische Signalgebung in Typ I und Typ II Zellen
(Applicant
Schütze, Stefan
)
Funktionelle Charakterisierung des humanen EML4-Proteins (ropp120)
(Applicant
Heidebrecht, Hans-Jürgen
)
Immunotherapy of pancreatic ductal adenocarcinoma with human gammadelta T lymphocytes
(Applicant
Wesch, Daniela
)
Lymphocyte immunotherapy (LIT) as a model system to predict humoral alloimmunity in transplantation: Validation of the Cambridge HLA immunogenicity algorithm
(Applicant
Kabelitz, Dietrich
)
Lysosome-related intra- and extracellular effector vesicles from human T and NK cells
(Applicant
Janßen, Ottmar
)
Molecular regulation of T follicular helper cell maintenance by Bach2 and RankL
(Applicant
Hutloff, Andreas
)
Molekulare Grundlagen der Tumor Nekrose Faktor(TNF)-vermittelten Inhibition des Insulinrezeptors im Diabetes mellitus Typ 2 (Insulinresistenz)
(Applicant
Adam, Dieter
)
Nck interaction partners: Molecular interactions and functional consequences
(Applicant
Lettau, Marcus
)
Regulation of human gamma/delta T cell activation by neutrophils: mechanisms and translational implications
(Applicant
Kabelitz, Dietrich
)
Regulation of the internalization and intracellular transport of Tumor Necrosis-Factor Receptor 1 (TNF-R1) and its impact on signal transduction and biological outcomes of TNF
(Applicant
Schütze, Stefan
)
Rolle von ICOS für die B-Zelldifferenzierung in einem in vivo Modell antigenspezifischer T-B Kooperation
(Applicant
Hutloff, Andreas
)
Signaltransduktion durch den 55 kDa TNF-Rezeptor: Molekulare und funktionelle Charakterisierung von Komponenten des N-SMase Signalwegs
(Applicant
Adam, Dieter
)
The costimulatory T-cell molecule ICOS as a novel therapeutic target for allergic airway disease
(Applicant
Hutloff, Andreas
)
The role of ICOS for T follicular helper responses
(Applicant
Hutloff, Andreas
)
The role of the transcription factor c-Maf in controlling mucosal inflammation in the intestine
(Applicant
Scheffold, Alexander
)
TNF-Rezeptosomen als signalübertragende Vesikel: Internalisierung und vesikuläres "trafficking" von aktivierten Rezeptoren als neuer Mechanismus intrazellulärer Signalübertragung
(Applicant
Schütze, Stefan
)
Priority Programmes
Completed projects
Clade specific virulence patterns of M. tuberculosis complex strains in human macrophages: Molecular mechanisms underlying phagosomal escape and induction of cell death.
(Applicants
Reiling, Norbert
;
Schütze, Stefan
)
Innate immune functions of human gamma-delta T lymphocytes
(Applicant
Kabelitz, Dietrich
)
Topology, regulation and function of acid sphingomyelinase in death receptor signaling
(Applicant
Schütze, Stefan
)
Clinical Research Units
Current projects
KFO 5010: CATCH ALL Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (ALL)
(Spokesperson
Baldus, Claudia
)
The Yin and Yang of anti-cancer CD4+ T cell responses in ALL
(Applicants
Bacher, Petra
;
Scheffold, Alexander
)
Completed projects
Memory T-Zell Dynamik bei Wegenerscher Granulomatose
(Applicant
Kabelitz, Dietrich
)
Research Units
Current projects
FOR 2799: Receiving and Translating Signals via the gamma-delta T Cell Receptor
(Spokesperson
Prinz, Immo
)
FOR 5042: The microbiome as a therapeutic target in inflammatory bowel diseases
(Spokesperson
Franke, Andre
)
Strategies to enhance cytotoxicity of tumor-infiltrating γδ T-cell subsets against autologous tumor cells
(Applicant
Wesch, Daniela
)
Targeting intestinal yeasts and pathogenic yeast-responsive CD4+ T cells in Crohn’s disease
(Applicants
Bacher, Petra
;
Franke, Andre
)
Collaborative Research Centres
Current projects
Autoantigen-specific T cells in pemphigoid diseases
(Project Heads
Scheffold, Alexander
;
Schmidt, Enno
)
Microbiota-specific T cell responses in pemphigoid diseases
(Project Heads
Bacher, Petra
;
Baines, John F.
)
Skin-infiltrating T and B cells in the pathogenesis of pemphigoid diseases
(Project Heads
Hutloff, Andreas
;
Ibrahim, Saleh M.
)
Completed projects
Analysis of the presentation of orally applied antigens and the specific T cell reaction: tolerance versus immunity
(Project Head
Scheffold, Alexander
)
Analysis of the presentation of orally applied antigens and the specific T cell reaction: tolerance versus immunity
(Project Heads
Radbruch, Andreas
;
Scheffold, Alexander
)
Central tasks of the Collaborative Research Centre
(Project Head
Kabelitz, Dietrich
)
Entwicklung und Durchführung von Technologien zur Antigen-spezifischen Zytomerie mittels Multiparamteranalyse
(Project Head
Scheffold, Alexander
)
FasL surface expression and signal transduction in lymphocytes and tumor cells
(Project Head
Janßen, Ottmar
)
Identifizierung und funktionelle Charakterisierung von intrazellulären Ceramid-Bindeproteinen
(Project Head
Schütze, Stefan
)
Mass Spectrometry based proteomics for the analysis of proteolytic events
(Project Heads
Janßen, Ottmar
;
Leippe, Matthias
;
Tholey, Andreas
)
Mechanism and implications of NKG2D ligand shedding
(Project Head
Kabelitz, Dietrich
)
Mechanismen der Regulation von Caspase-unabhängigem Zelltod und Zellproliferation durch Sphingolipidmediatoren
(Project Head
Adam, Dieter
)
Präparative Zellsortierung und Modifikation von regulatorischen Zellpopulationen
(Project Heads
Radbruch, Andreas
;
Radtke, Hartmut
;
Scheffold, Alexander
)
Proliferation and suppression of T cells: Role of TLR ligands and IL-6
(Project Heads
Kabelitz, Dietrich
;
Wesch, Daniela
)
Proliferative und proapoptiotische Signale durch den Todesrezeptor-vermittelten FADD/Caspase-Signalweg in murinen Fibroblasten
(Project Head
Adam, Sabine
)
Proteolysis-dependent post-translational modifications in control of the death factor CD95L
(Project Head
Janßen, Ottmar
)
Proteolysis in the regulation of non-apoptotic cell death
(Project Heads
Adam, Dieter
;
Schütze, Stefan
)
Proteolytic modulation of intestinal CD4 T helper cell function and immune homeostasis
(Project Head
Scheffold, Alexander
)
Redirecting the antigen-specificity of polyclonal regulatory T cells to optimize their therapeutic efficacy and safety
(Project Heads
Fillatreau, Simon
;
Scheffold, Alexander
;
Uckert, Wolfgang
)
Role of subcellular compartments and vesicular trafficking in TNF signaling
(Project Head
Schütze, Stefan
)
Role of ubiquitination and proteolysis in the regulation of pro- and anti-apoptotic TNF-R1 signaling
(Project Head
Schütze, Stefan
)
Rolle von Gamma-T-Lymphozyten in der epithelialen Abwehr
(Project Head
Kabelitz, Dietrich
)
Rolle von TDAG51 bei Zellaktivierung, Proliferation und Apoptose
(Project Head
Kabelitz, Dietrich
)
Rolle von TDAG51 bei Zellaktivierung, Proliferation und Apoptose
(Project Head
Kabelitz, Dietrich
)
SFB 415: Specificity and Pathophysiology of Signal Transduction Pathways
(Spokesperson
Kabelitz, Dietrich
)
Major Research Instrumentation
Completed projects
5-Laser Multiparameter Spectral Flow-Cytometer
Hochauflösendes Zytometer
Multicolor Cell sorter
CRC/Transregios
Current projects
Dissecting microbial subcellular structures as targets for specific Treg-based therapies
(Project Heads
Bacher, Petra
;
Scheffold, Alexander
)
Induction of Antigen-specific Treg responses as therapeutic targets for chronic inflammatory diseases
(Project Heads
Bacher, Petra
;
Scheffold, Alexander
)
Completed projects
Germinal Centre-like B Cells in Inflamed Tissues
(Project Head
Hutloff, Andreas
)
Scientific Networks
Completed projects
Mechanisms of generation and maintenance of immune tolerance in pregnancy
(Applicant
Herse, Florian
)
Clusters of Excellence
Completed projects
EXC 306: Inflammation at Interfaces
(Spokesperson
Schreiber, Stefan
)
Additional Information
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