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Institution
Charité - Universitätsmedizin Berlin
Charité Campus Mitte
Institut für Biochemie
Address
Virchowweg 6
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Priority Programmes
Current projects
Elucidating mechanisms of metabolic interaction and gene function in spatially interacting microbiome keystone bacteria
(Applicants
Ralser, Markus
;
Stecher-Letsch, Barbara
)
MiMiCry: Mimicking Nature by Continuous Production of Antimicrobials in Mixed Cultures of Synthetic Strains
(Applicants
Lindner-Mehlich, Steffen
;
Takors, Ralf
)
Completed projects
Biochemical and functional analysis of multicatalytic proteinase subtypes in 20S and 26S proteasoms
(Applicant
Dahlmann, Burkhardt
)
Biochemical and functional characterization of ubiquitin-like proteines ISG15 and FAT10 in human dendritic cells.
(Applicant
Kloetzel, Peter Michael
)
Expression regulation of phospholipid hydroperoxide glutathione peroxidase isoforms. Transcriptional and post-transcriptional processes
(Applicant
Kühn, Hartmut
)
Functional characterization of ubiquitin-like modifier ISG15 in murine enterovirus myocarditis
(Applicant
Beling, Antje
)
Funktionelle Analyse der Proteasomregulatoren PI31, PA28y/Ki und warum PA28aß die Generierung von MHC Klasse I Epitopen unterstützt Functional analysis of proteasome regulators PI31, PA28y/Ki and why the PA28aß supports the generation of MHC class I antigens
(Applicant
Kloetzel, Peter Michael
)
Implications of ß-subunit exchanges and of interactions with the activator PA28 for the cleavage preferences of the 20S proteasome: A quantitative analysis based on kinetic experiments
(Applicant
Holzhütter, Hermann-Georg
)
SPP 1045: Struktur, Funktion und Regulation des 20S/26S Ubiquitin-Proteasomsystems
(Spokesperson
Kloetzel, Peter Michael
)
Untersuchungen zur strukturellen und funktionellen Plastizität des 20S/26S-Proteasoms und assoziierter regulatorischer Komplexe in Mikrogliazellen der Maus
(Applicant
Stohwasser, Ralf
)
Research Units
Current projects
FOR 5228: Membrane trafficking processes underlying presynaptic proteostasis
(Spokesperson
Kreutz, Michael R.
)
Presynaptic crosstalk of autophagy and proteasomal activity to maintain proteostasis
(Applicants
Eickholt, Britta
;
Kirstein, Janine
)
Completed projects
Glycosidierte Phospholipidanaloga als topische Dermatika und Inhibitoren des Tumorwachstums
(Applicant
Danker, Kerstin
)
Optimiertes ß-Faltblattmodul für die effektive Expression von Fab-Fragmenten in E.coli
(Applicant
Höhne, Wolfgang
)
Verwendung von Peptidbibliotheken zur Auffindung von Chitinaseinhibitoren und strukturelle Charakterisierung der Wechselwirkung
(Applicant
Höhne, Wolfgang
)
Research Grants
Current projects
Ageing, proteotoxic stress and the neuronal cytoskeleton: Analyses of the age-dependent challenges of the actin filament system
(Applicants
Eickholt, Britta
;
Kirstein, Janine
)
Anti-inflammatory Periodontal Therapy with Smart Drug-Delivery-Systems (PERIO- SmaDDS)
(Applicants
Danker, Kerstin
;
Dommisch, Henrik
;
Haag, Rainer
)
Detailing the Feedback Interplay between Phosphoinositides, Rho GTPases and Actin Governing Cell Polarisation
(Applicant
Rocks, Oliver
)
Molecular characterization of Rab8 membrane tubules as neuromodulatory and neuroprotective membrane trafficking organelles
(Applicant
Murk, Kai
)
Shaping the glial scar during CNS injury by manipulating the actin cytoskeleton in astrocytes
(Applicant
Eickholt, Britta
)
Completed projects
Adaptation of proteasome composition in inflammatory response - the impact of the hybridproteasome
(Applicant
Beling, Antje
)
Allosteric lipoxygenase effectors as potential drugs
(Applicant
Kühn, Hartmut
)
Analyse der molekularen und biochemischen Mechanismen der Proteasomassemblierung
(Applicant
Kloetzel, Peter Michael
)
Die cytoplasmatischen Domänen der Kollagen-bindenden alpha-1 und alpha3-Integrinuntereinheiten: Ihre Funktion bei Adhäsion, Migration und Differenzierung von PC12-Zellen
(Applicant
Danker, Kerstin
)
Endolysosomal targeting of Protein Kinase A by ARHGAP36
(Applicant
Rocks, Oliver
)
Funktion von ISG15 bei viralen Herzmuskelerkrankungen
(Applicant
Beling, Antje
)
Influence of cytokines and infection on proteasomal antigen processing
(Applicant
Kuckelkorn, Ulrike
)
Investigation of the translational potential of the ISG15 system for treatment of virus-induced inflammatory cardiomyopathy.
(Applicant
Beling, Antje
)
Investigations into the Distribution, the Biological Role and the Evolution of Lipoxygenases. Functional Charcterization of Genetically Modified Mice with Humanized Reaction Specificity.
(Applicants
Heydeck, Dagmar
;
Kühn, Hartmut
)
Investigations into the role of eicosanoid synthesizing enzymes in foam cell formation and human atherogenesis
(Applicant
Kühn, Hartmut
)
Molecular and therapeutic aspects of proteolytic machineries in immune cells for cardiac inflammation.
(Applicants
Beling, Antje
;
Kaya, Ziya
)
Neuartige glycosidierte Phospholipidanaloga als topische Dermatika und Inhibitoren des Tumorwachstums
(Applicant
Danker, Kerstin
)
Quantitative proteomics using novel trifunctionalized metal coded affintiy tags
(Applicant
Linscheid, Michael
)
Structural analysis of the anti-myc tag antibody 9E10 in complex with the c-myc epitope and the mutagenesis of the binding region for the characterization and optimization of the interaction
(Applicant
Höhne, Wolfgang
)
Strukturelle Ursachen für Positionsspezifität von Lipoxygenasen und für deren Fähigkeit zur Membranbindung
(Applicant
Kühn, Hartmut
)
Studies on the role of ALOX15 and its products in murine experimental colitis.
(Applicants
Kühn, Hartmut
;
Weylandt, Ph.D., Karsten-Henrich
)
The function of the Ubiquitin-Proteasome-System (UPS) in MHC class I antigen processing in target cells and maturing human dendritic cells (hDCs).
(Applicant
Kloetzel, Peter Michael
)
Transcription factor 11 (TCF 11) is a transcriptional regulator of proteasome subunit genes - what in turn regulates TCF 11 activation?
(Applicants
Koch, Annett
;
Krüger, Elke Beate
)
Untersuchung der Funktionsweise des HERP Proteins
(Applicant
Seeger, Michael
)
Untersuchung der Prozessierung von MHC-Klasse-I-restringierten Antigenen durch Selektion und Analyse von mutanten Melanomzellen mit defekter Antigenpräsentation
(Applicant
Kloetzel, Peter Michael
)
Untersuchungen zum Mechanismus und zur Regulation der Biosynthese des Hepoxilins A3 sowie über seine biologische Funktionen
(Applicant
Nigam, Santosh
)
Collaborative Research Centres
Current projects
Metabolic reprogramming steered by ISGylation in HFpEF
(Project Heads
Beling, Antje
;
Berndt, Nokolaus
)
Molecular technology infrastructure and support
(Project Heads
Altmüller, Janine
;
Lodrini, Marco
;
Ralser, Markus
)
Plasma proteome and metabolome signatures to better understand, monitor and predict neuroblastoma evolution
(Project Heads
Deubzer, Ph.D., Hedwig E.
;
Ralser, Markus
)
TF-PAR2 signaling in viral infections
(Project Heads
Beling, Antje
;
Ruf, Wolfram
)
Completed projects
Analyses of the function and regulation of the PTEN suppressor during early brain development
(Project Head
Eickholt, Britta
)
A PRG2-PTEN based membrane scaffold involved in the formation of axon branches
(Project Head
Eickholt, Britta
)
Bacterial [NiFe]-hydrogenases: key reactions of the biological activation of molecular hydrogen
(Project Heads
Friedrich, Bärbel
;
Höhne, Wolfgang
;
Krauß, Norbert
)
Das Proteasom in Mikroglia und Astrozyten und seine Rolle bei Infektiones- und Entzündungsprozessen im ZNS
(Project Heads
Dahlmann, Burkhardt
;
Kloetzel, Peter Michael
)
Einfluss von zytosolischen und im ER lokalisierten Aminopeptidasen auf die post-Proteasomale Generierung viraler MHC Klasse I Liganden
(Project Heads
Kloetzel, Peter Michael
;
Seifert, Ulrike
)
Geschäftsstelle
(Project Head
Kloetzel, Peter Michael
)
Integrin-vermittelte Signaltransduktion: Die funktionelle Bedeutung der cytoplasmatischen Domänen der a1- und a3-Integrin-Untereinheiten
(Project Head
Danker, Kerstin
)
Membrane biogenesis modelling of a Toxoplasma gondii-infected human cell and deduction of underlying metabolic principles
(Project Heads
Gupta, Nishith
;
Holzhütter, Hermann-Georg
;
Lucius, Richard
)
Multiparameter-Durchflußcytometrie zur Einzelzellsortierung
(Project Head
Danker, Kerstin
)
Neuronal excitation as a perturbation of the energetic and osmotic homeostasis: Implications for robust network behaviour
(Project Heads
Holzhütter, Hermann-Georg
;
Kann, Oliver
)
Regulation of proteasome modules
(Project Heads
Kloetzel, Peter Michael
;
Krüger, Elke Beate
)
Regulatorische Determinanten zur Produktion von MHC Klasse I-Liganden durch das Proteasomensystem
(Project Head
Kloetzel, Peter Michael
)
SFB 421: Protective and Pathological Effects of Antigen Processing
(Spokesperson
Kloetzel, Peter Michael
)
Zentrale Proteinchemie
(Project Head
Henklein, Peter
)
CRC/Transregios
Current projects
Human chronotyping and circadian data analysis
(Project Heads
Buchauer, Lisa
;
Kramer, Achim
;
Ralser, Markus
)
Metabolic switches regulating stress tolerance in eukaryotes
(Project Heads
Dick, Tobias
;
Ralser, Markus
)
USP18 as an immune check-point regulator for microglial activation
(Project Heads
Beling, Antje
;
Knobeloch, Klaus-Peter
)
Completed projects
Pathogen induced alterations of the Ubiquitin-Proteasome-System (UPS) during the Innate Immune Response in the Lung
(Project Heads
Kloetzel, Peter Michael
;
Seifert, Ulrike
)
Phosphoinositide switches in neurons: implications for membrane dynamics, axonal morphogenesis and the cortical actin cytoskeleton
(Project Head
Eickholt, Britta
)
Role of Proteasomes in Acute and Chronic Enterovirus Myocarditis
(Project Heads
Beling, Antje
;
Kloetzel, Peter Michael
;
Kuckelkorn, Ulrike
)
The role of immunoproteasomes and the ubiquitin system in inflammatory processes in mouse models of Alzheimer's and Parkinson's disease
(Project Heads
Aktas, Orhan
;
Heppner, Frank
;
Kloetzel, Peter Michael
;
Krüger, Elke Beate
)
Major Research Instrumentation
Completed projects
Hochauflösendes Flüssigkeitschromatographie-Massenspektrometriesystem (LC-MS)
Research Training Groups
Completed projects
GRK 80: Model Studies of Structures, Properties and Recognition of Biologically Relevant Molecules at Atomic Level
(Spokesperson
Höhne, Wolfgang
)
GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
(Spokesperson
Heinrich, Reinhart
)
GRK 1772: Computational Systems Biology
(Spokesperson
Klipp, Edda
)
International Research Training Groups
Completed projects
GRK 1360: Genomics and Systems Biology of Molecular Networks
(Spokesperson
Klipp, Edda
)
GRK 1673: Functional Molecular Infection Epidemiology
(Spokesperson
Wieler, Lothar H.
)
Major Instrumentation Initiatives
Completed projects
Lattice Light Sheet Microscope (LLSM)
Clusters of Excellence
Completed projects
EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
(Spokesperson
Schmitz, Dietmar
)
Additional Information
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