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Institution
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
c/o Charité - Universitätsmedizin Berlin
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Grants
Current projects
Investigating the role of NMDA receptor hypofunction in psychosis using neuroimaging across scales and species
(Applicants
Prüß, Harald
;
Stroh, Albrecht
)
Completed projects
Epitopic targets of the monoclonal auto-antibody repertoire in autoimmune encephalitis
(Applicant
Prüß, Harald
)
Identification of the memory signature: gene expression patterns underlying synapse strengthening and weakening
(Applicant
Dean, Camin
)
Immune-mediated pathogenesis and development of autoimmunity in neurological manifestations of COVID-19
(Applicants
Franke, Christiana
;
Prüß, Harald
;
Warnke, Clemens
)
“NMDA receptor hypofunction revisited: Cellular mechanisms of psychosis in mouse models of NMDA receptor ablation”
(Applicants
Liebscher, Sabine
;
Prüß, Harald
)
Regulation of dense core vesicle trafficking and capture by synaptotagmin 4
(Applicant
Dean, Camin
)
Regulation of post-synaptic receptor recycling by synaptotagmin 3
(Applicant
Dean, Camin
)
Rewiring of GABAergic inhibitory cells recruited during spatial representation
(Applicants
Haberl, Matthias
;
Viana da Silva, Ph.D., Silvia
)
Synaptic autoimmunity in neuropsychiatric diseases
(Applicant
Prüß, Harald
)
Visualizing BDNF cell-to-cell transfer and its effects on synapse and circuit function
(Applicant
Dean, Camin
)
Heisenberg Grants
Completed projects
Molecular Mechanisms of Learning, Remembering and Forgetting
(Applicant
Dean, Camin
)
Research Units
Current projects
Condensation-dependent chaperone interactions of Tau and TDP-43 in the brain
(Applicant
Wegmann, Ph.D., Susanne
)
FOR 3004: Synaptic pathology in autoimmune encephalitis – SYNABS
(Spokesperson
Geis, Christian
)
FOR 5872: Chaperone-mediated regulation of the emergence of disease-causing amyloids inside biomolecular condensates
(Spokesperson
Kirstein, Janine
)
Maintaining presynaptic function in dopaminergic synapses
(Applicants
Gundelfinger, Eckart D.
;
Rosenmund, Christian
)
Origin and Diversity of Pathogenic Human Monoclonal Antibodies and T cells in Tumor-associated Autoimmune Neurological Disorders
(Applicants
Prüß, Harald
;
Wahl, Ilka Maria
)
Completed projects
Developmental and synaptic defects caused by transplacental transmission of NMDA receptor antibodies
(Applicants
Kaindl, Angela
;
Kirmse, Knut
;
Prüß, Harald
)
Origin and diversity of pathogenic human monoclonal antibodies to the NMDA receptor
(Applicants
Prüß, Harald
;
Wardemann, Hedda
)
Research Fellowships
Completed projects
Cellular mechanisms facilitating the spreading of Tau pathology in Alzheimer's disease: uptake, release and synaptic cell-to-cell transmission of Tau nano-aggregates in neuronal networks
(Applicant
Wegmann, Ph.D., Susanne
)
Die Rolle von RIM 1 alpha und seinen Isoformen bei der Ausbildung und Funktion der präsynaptischen aktiven Zone
(Applicant
Bruederle, Cathrin
)
Mechanismen der Endocytose von synaptischen Vesikeln
(Applicant
Ackermann, Frauke
)
Mechanisms regulating the assembly, dynamics and stability of mammalian presynaptic active zones
(Applicant
Maas, Ph.D., Christoph
)
Signalspezifische Dynamik postssynaptischer Adapterproteine
(Applicant
Specht, Christian
)
Transsynaptic signaling influenced trough the dynamics of ProSAP/Shank proteins at excitatory synapses
(Applicant
Grabrucker, Andreas
)
Collaborative Research Centres
Current projects
Development of molecular tools for manipulating and studying memory engrams
(Project Heads
Hegemann, Peter
;
Rosenmund, Christian
;
Rost, Benjamin
;
Schmitz, Dietmar
;
Vierock, Johannes
)
SFB 1286: Quantitative Synaptology
(Spokesperson
Rizzoli, Ph.D., Silvio-Olivier
)
SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems
(Spokesperson
Larkum, Matthew
)
Completed projects
SFB 958: Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
(Spokespersons
Haucke, Ph.D., Volker
;
Sigrist, Stephan J.
)
Synaptic Mechanisms underlying Phelan McDermid and Asperger's Syndrome
(Project Head
Garner, Craig C.
)
Synaptic scaffold proteins regulate presynaptic proteostasis
(Project Heads
Garner, Craig C.
;
Schmitz, Dietmar
)
The role of synaptotagmins in olfactory processing
(Project Head
Dean, Camin
)
Priority Programmes
Current projects
Condensation of ribosomal proteins in ribosome biogenesis and neurological ribosomopathy
(Applicants
Kraushar, Ph.D., Matthew
;
Nikolay, Rainer
;
Wegmann, Ph.D., Susanne
)
Completed projects
Delineating and testing a microcircuit model of parahippocampal phase precession
(Applicants
Brecht, Michael
;
Kempter, Richard
;
Schmitz, Dietmar
)
Development and Application of New Optogenetic Tools Targeted to Intracellular Compartments
(Applicants
Hegemann, Peter
;
Rost, Benjamin
)
Engineering of Chrimson for Subcellular Optogenetic application
(Applicants
Elstner, Marcus
;
Hegemann, Peter
;
Rost, Benjamin
)
Molecular and Cellular Determinants of Tau Protein Condensation into Dense Liquid Phases
(Applicants
Betzel, Christian
;
Mandelkow, Eckhard
;
Wegmann, Ph.D., Susanne
)
Clinical Research Units
Current projects
Antibody target identification and novel diagnostics
(Applicants
Prüß, Harald
;
Wanker, Erich E.
)
Autoantibody pathogenicity in antibody-induced and common neurodegenerative diseases
(Applicants
Schmitz, Dietmar
;
Wegmann, Ph.D., Susanne
)
Disease models and novel diagnostic imaging markers
(Applicants
Makowski, Marcus R.
;
Prüß, Harald
)
Establishing a Core Unit for Research and Treatment for patients with antibody-mediated neurological diseases
(Applicants
Prüß, Harald
;
Radbruch, Helena
;
Ripke, Stephan
)
KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
(Spokesperson
Endres, Matthias
)
CRC/Transregios
Current projects
Rewiring of GABAergic inhibitory cells recruited during spatial encoding
(Project Heads
Haberl, Matthias
;
Viana da Silva, Ph.D., Silvia
)
Clusters of Excellence (ExStra)
Current projects
EXC 2049: NeuroCure – Comprehensive approaches to neurological and psychiatric disorders – from mechanisms to interventions –
(Spokespersons
Kühn, Andrea
;
Schmitz, Dietmar
)
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