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Institution
Ludwig-Maximilians-Universität München
Fakultät für Chemie und Pharmazie
Department Pharmazie
Address
Butenandtstraße 5
81377 München
Deutschland
GERiT
This institution in GERiT
81377 München
Projects
Research Grants
Current projects
Synthesis and pharmacology of selective non-steroidal inhibitors of 24-dehydrocholesterol reductase
(Applicants
Bracher, Franz
;
Müller, Christoph
)
The role of HCN channels for the synchronization process in the sinoatrial node of the heart
(Applicants
Biel, Martin
;
Fenske, Stefanie
;
Wahl-Schott, Christian
)
Completed projects
Cyclin dependent kinase 5 (Cdk5) - Characterization of its functional relevance for endothelial cell migration and angiogenesis
(Applicant
Zahler, Stefan
)
Entwicklung eines spezifischen Inhibitors der Proteinkinase DYRK1A
(Applicants
Becker, Walter
;
Bracher, Franz
)
Functional roles and regulation of HCN channels iin neuronal circuits
(Applicant
Biel, Martin
)
Funktionelle Charakterisierung von TPCN2 Kanälen in vitro und in vivo
(Applicant
Wahl-Schott, Christian
)
LRP1-targeted carbon nanodots for crossing BBB and delivering small molecule or protein drugs into brain
(Applicant
Wagner, Ernst
)
Molekulare Analyse des ziliären Transports von Zyklonukleotid-aktivierten Kationenkanälen
(Applicant
Michalakis, Stylianos
)
Programmed dual targeted lipopolymeric delivery systems for cancer gene therapy
(Applicant
Wagner, Ernst
)
Role of elements in the NO/cGMP pathway for associative fear leraning and synaptic plasticity in the lateral amygdala studied in various mouse models
(Applicant
Kleppisch, Thomas
)
Struktur-Wirkungs-Studien zu Peptidantibiotika vom Biphenomycin-Typ
(Applicant
Paintner, Franz F.
)
The role of Cdk5 as target in hepatocellular carcinoma
(Applicants
Vollmar, Angelika
;
Zahler, Stefan
)
Untersuchungen zur Physiologie von Schrittmacherkanälen an Hand HCN2-defizienter Mäuse
(Applicant
Biel, Martin
)
Wirkungen von Stickoxid bei der postoperativen Reperfusion menschlicher Herzen
(Applicant
Massoudy-Touiserkan, Parwis
)
Research Units
Current projects
Development of a Gene Therapy for Usher Syndrome Type 1B (USH1B)
(Applicant
Biel, Martin
)
FOR 5621: OCU-GT: Addressing the Unmet Needs in Ocular Gene Therapy
(Spokesperson
Michalakis, Stylianos
)
Completed projects
Impact of archazolid on tumor metabolism
(Applicant
von Schwarzenberg, Karin
)
Selektive Hemmung des Transkriptionsfaktors NF-kB in Kupfferzellen - Bedeutung für den Ischämie-Reperfusionsschaden der Leber
(Applicant
Vollmar, Angelika
)
Syntheses of pretubulysin derivatives for targeted tumor therapies
(Applicants
Kazmaier, Uli
;
Wagner, Ernst
)
Collaborative Research Centres
Current projects
Controlling cellular function by structured environments: Artificial angioge-nesis
(Project Head
Zahler, Stefan
)
Nucleic acid nanoagents utilizing the intracellular microRNA-200c machinery for switching functions in breast cancer cells
(Project Head
Wagner, Ernst
)
Synthesis and characterization of low-molecular modulators of epigenetic target enzymes
(Project Head
Bracher, Franz
)
Completed projects
Control of neuronal circuit activity by HCN channel modulation
(Project Head
Biel, Martin
)
Einfluß von Redox-Streß auf die Aktivität von TACE und Calpain bei Ischämie und Reperfusion
(Project Heads
Becker, Bernhard F.
;
Zahler, Stefan
)
Funktion und Regulation Zyklonukleotid-regulierter Kationenkanäle
(Project Head
Biel, Martin
)
Synthese von Nanopartikeln (künstliche Viren)
(Project Head
Wagner, Ernst
)
The role of HCN channels in the septo-hippocampal circuit
(Project Heads
Biel, Martin
;
Wahl-Schott, Christian
)
Transcriptional addressing of dendritic cells (DCs) with the help of an hPFscn1 derived promotor using DC-addressing polymers for tumortherapy
(Project Heads
Bros, Matthias
;
Wagner, Ernst
;
Zentel, Rudolf
)
Priority Programmes
Current projects
A multiplexing CRISPRa approach for gene-independent therapy of retinal degeneration
(Applicant
Biel, Martin
)
Optimization of treatment flow to improve performance of retinal gene therapy
(Applicant
Seeliger, Mathias
)
Completed projects
Receptor-targeting and intracellular disassembly of gene vectors
(Applicant
Ogris, Manfred
)
Clinical Research Units
Completed projects
Evaluation der Wirksamkeit lokaler Gentherapie bei CNG Kanal-difizienten Mausmodellen für erbliche Netzhauterkrankungen
(Applicant
Seeliger, Mathias
)
Evaluation der Wirksamkeit lokaler Gentherapie bei CNG Kanal-difizienten Mausmodellen für erbliche Netzhauterkrankungen
(Applicant
Biel, Martin
)
Major Research Instrumentation
Completed projects
Aufrechtes Konfokales Mikroskop mit Resonanzscanner
GC-gekoppeltes Tandem-Massenspektrometer
Inverses Konfokales Laserscanning Mikroskop mit FCS/FCCS
In vivo Imaging Einheit
CRC/Transregios
Current projects
Exploring TPC2 as target for age-dependent macular degeneration therapy
(Project Heads
Biel, Martin
;
Michalakis, Stylianos
)
Research Training Groups
Current projects
GRK 2338: Targets in Toxicology - Deciphering Therapeutic Targets in Lung Toxicology
(Spokesperson
Gudermann, Thomas
)
Graduate Schools
Completed projects
GSC 82: Graduate School Of Systemic Neurosciences (GSN-LMU)
(Spokesperson
Grothe, Benedikt
)
Clusters of Excellence
Completed projects
EXC 4: Nanosystems Initiative Munich (NIM)
(Spokespersons
Bein, Thomas
;
Feldmann, Jochen
)
EXC 114: Munich Center for Integrated Protein Science (CIPSM)
(Spokesperson
Carell, Thomas
)
Additional Information
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