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Universitätsklinikum Köln
Klinik II für Innere Medizin
Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin

Address Kerpener Straße 62
50937 Köln
Deutschland

GERiT This institution in GERiT

50937 Köln

Projects

Research Fellowships
- Completed projects
Research Grants
- Current projects
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Internationale konkurenzfähige Forschung im Bereich molekularbiologischen, medizinisch orientierten Grundlagenforschung zur Aufklärung der molekularen Pathogenese angeborener Nierenerkrankungen; zügiger Ablauf des Junior Group Leader hin zur Berufung auf eine volle Professur.
    (Applicant Benzing, Thomas )
Clinical Research Units
- Current projects
  - Alterations of slit diaphragm proteins and the pathogenesis of albuminuria and FSGS
    (Applicants Benzing, Thomas ; Bozek, Katarzyna )
  - Central mouse generation, phenotyping and imaging
    (Applicants Bozek, Katarzyna ; Schauss, Astrid )
  - Coordination Funds
    (Applicant Benzing, Thomas )
  - Gene-regulatory networks in podocytes in health and disease
    (Applicants Beyer, Andreas ; Kann, Martin )
  - KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
    (Spokesperson Benzing, Thomas )
  - Podocyte lncRNAs – a novel player in focal-segmental glomerulosclerosis
    (Applicants Dieterich, Christoph ; Müller, Roman-Ulrich )
  - The role of mononuclear phagocytes in the development of FSGS
    (Applicants Brähler, Sebastian ; Kurts, Christian )
  - Unraveling metabolic signaling in podocytes and its contribution to FSGS
    (Applicants Brinkkötter, Paul-Thomas ; Völker, Linus )
- Completed projects
  - DNA damage response pathways in podocytes: novel targets to treat focal segmental glomerulosclerosis
    (Applicants Kurschat, Christine ; Schumacher, Björn )
  - Identification and functional characterization of new components of TOR signalling in C. elegans
    (Applicant Neumann-Haefelin, Elke )
Clinical Trials
- Current projects
  - The STOP-PKD trial (SGLT2-inhibition TO improve Prognosis in Polycystic Kidney Disease), an investigator-driven, multi-center, randomized, placebo-controlled, double-blind trial to compare SGLT2-inhibition versus placebo in patients with ADPKD
    (Applicant Müller, Roman-Ulrich )
Research Units
- Current projects
  - Cell-non-autonomous control of kidney podocyte proteostasis
    (Applicant Benzing, Thomas )
  - Dynamic regulation of ciliary RNA-binding proteins in kidney epithelial cells
    (Applicants Müller, Roman-Ulrich ; Schermer, Bernhard )
  - FOR 2743: Mechanical Stress Protection
    (Spokesperson Höhfeld, Jörg )
  - FOR 5504: Physiological causes and consequences of genome instability
    (Spokesperson Schumacher, Björn )
  - FOR 5547: Dissecting primary cilia dynamics in tissue organization and function
    (Spokesperson Gopalakrishnan, Ph.D., Jay )
  - FOR 5762: Cell Non-Autonomous Regulation of Organismal Proteostasis
    (Spokesperson Vilchez, David )
  - Mechanical stress protection at the kidney filtration barrier
    (Applicants Benzing, Thomas ; Rinschen, Markus )
  - Metabolic deregulation, genome instability, and the progression of chronic kidney disease
    (Applicants Benzing, Thomas ; Schermer, Bernhard )
Collaborative Research Centres
- Current projects
  - Deregulation of mTOR signaling pathways and metabolic reprogramming in VHL-dependent clear cell renal cell carcinoma
    (Project Heads Neumann-Haefelin, Elke ; Schlosser, Pascal ; Timmers, Marc )
  - Regulated cell death and kidney fibrosis as a consequence of mutation of cilia-associated genes
    (Project Heads Benzing, Thomas ; Schermer, Bernhard )
  - Transcript quality effects of RNAPII speed variation
    (Project Heads Beyer, Andreas ; Müller, Roman-Ulrich )
- Completed projects
Major Research Instrumentation
- Completed projects
  - Konfokales Laserscanning-Mikroskop für Multifluoreszenz-Detektion
WBP Fellowship
- Completed projects
  - Deep single-cell RNA sequencing-based analysis of early transcriptional responses in inflammatory and non-inflammatory podocyte disease
    (Applicant Butt, Linus )
CRC/Transregios
- Current projects
  - Central tasks and coordination of the collaborative research center
    (Project Head Benzing, Thomas )
  - Deciphering intraglomerular inflammatory signaling in podocyte homeostasis and disease
    (Project Heads Brähler, Sebastian ; Tomas, Nicola )
  - Defending podocyte integrity against mechanical strain: Unveiling mechanosensitive multiprotein complex signaling at the slit diaphragm
    (Project Heads Benzing, Thomas ; Bozek, Katarzyna ; Butt, Linus )
  - Mitochondrial control of metabolic signaling in podocytes
    (Project Heads Brinkkötter, Paul-Thomas ; Ester, Lioba )
  - Quantifying podocyte damage at the single-cell level and in tissue context
    (Project Heads Beyer, Andreas ; Kann, Martin )
  - RNA binding of metabolic enzymes in the crosstalk of metabolic regulation and signaling in podocyte disease
    (Project Heads Huppertz, Ina ; Müller, Roman-Ulrich )
  - TRR 422: PodoSigN – Podocyte Signaling Networks - From Basic Concepts to Disease Understanding
    (Spokesperson Benzing, Thomas )
Research Training Groups
- Completed projects
  - GRK 2407: Inflammatory and cellular stress signaling: Switches to vascular dysfunction
    (Spokesperson Baldus, Stephan )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2030: CECAD - Excellent in Aging Research
    (Spokespersons Benzing, Thomas ; Hoppe, Ph.D., Thorsten ; Niessen, Carien )
Clusters of Excellence
- Completed projects
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases
    (Spokesperson Brüning, Jens Claus )

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