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TRR 43:  The Brain as a Target of Inflammatory Processes

Subject Area Medicine
Term from 2008 to 2016
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 29837756
 
In the past 5 years, our understanding of the implications and the importance of immune processes contributing to CNS diseases has progressed at a remarkable pace. In order to better facilitate the translation of the findings to the human situation, the understanding of immune mechanisms by dissecting the molecular cues of neuroimmune signaling pathways is necessary. We know now that immune actions are not only involved in prototypical inflammatory brain diseases such as multiple sclerosis (MS) or encephalitides, but also play an important role in the pathogenesis and pathology of central nervous system (CNS) disorders that are generally considered to be primarily noninflammatory, such as stroke, brain tumors and neurodegenerative disorders, such as Alzheimer's disease.Although the initiating events may differ considerably between various CNS diseases, they seem, at least in some instances, to utilize common pathways for the cross talk between the immune and the nervous systems. Deciphering these common - or divergent - pathways is a common denominator for the research of the Collaborative Research Centre consortium. While insights into immune functions in certain CNS diseases have already opened up new avenues for preventing or treating these diseases, the Collaborative Research Centre envisages transferring knowledge of immune actions in a given CNS disease to CNS disorders with different origins but similar immune actions. Recent insights have led to a discrimination of CNS disorders as having either an innate-immune or an adaptive-immune component. The Collaborative Research Centre has been at the forefront of exciting discoveries as to the importance of immune processes in CNS diseases, and will thus continue its successful approach. Only recently it became clear how essential it is to engage researchers of a variety of educational backgrounds in the efforts to develop a coherent physiological and pathophysiological description of the innate and adaptive immune actions in CNS disorders, and to translate new insights into research and treatment strategies. The most difficult questions in the field can often be most effectively addressed when investigators with different educational background share a fundamental understanding of complex organ systems and - as shown in this Collaborative Research Centre - synergistically cooperate in the best possible way.
DFG Programme CRC/Transregios

Completed projects

Applicant Institution shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
 
 

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