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Institution
Uniklinik Köln
Klinik für Dermatologie und Venerologie
Address
Kerpener Straße 62
50937 Köln
Deutschland
GERiT
This institution in GERiT
50937 Köln
Projects
Research Units
Current projects
FOR 2240: (Lymph)Angiogenesis And Cellular Immunity In Inflammatory Diseases Of The Eye
(Spokesperson
Cursiefen, Claus
)
FOR 2599: Tissue type 2 responses: Mechanisms of induction and regulation
(Spokesperson
Roers, Axel
)
Regulators of type 2 immunity in tissue regeneration
(Applicant
Eming, Sabine
)
Completed projects
Bedeutung des vascular Endothelial Growth Factor (VEGF) bei der physiologischen und pathologischen Wundheilung sowie Möglichkeiten seines gentherapeutischen Einsatzes
(Applicant
Eming, Sabine
)
Bedeutung des Vascular Endothelial Growth Factor (VEGF) bei der physiologsichen und pathologischen Wundheilung sowie Möglichkeiten seines gentherapeutischen Einsatzes
(Applicant
Sollberg, Stephan
)
FOR 265: Zell-Zell- und Zell-Matrixwechselwirkungen in der Haut, Kontrolle von Barriere und Abwehrfunktion
(Spokesperson
Krieg, Thomas
)
Gewebespezifische Inaktivierung von alpha2-Integrin und Nidogen in der Haut - Untersuchungen zur Bedeutung dieser Proteine für physiologische und pathologische Vorgänge in der Haut
(Applicant
Krieg, Thomas
)
Membranständige Matrix-Metalloproteinasen: ihre Rolle für Zellwanderung und Tumorinvasion
(Applicant
Mauch, Cornelia
)
Molekulare Grundlagen von epidermal-dermalen Zellinteraktionen: Die Rolle von Zytokinen und Wachstumsfaktoren
(Applicant
Smola, Hans
)
Myeloid cell function in corneal hem- and lymphangiogenesis
(Applicants
Eming, Sabine
;
Hos, Deniz
)
Zentrales Projekt
(Applicant
Krieg, Thomas
)
Research Grants
Current projects
Cologne Clinician Scientist Program
(Applicant
von Stebut-Borschitz, Ruth Esther
)
Contribution of fibroblast-MMP14 to allergic-type of contact dermatitis reactions
(Applicant
Zigrino, Ph.D., Paola
)
Controlling collagen deposition by fibroblasts in cutaneous fibrosis by targeting TANGO1 function
(Applicants
Krieg, Thomas
;
Sengle, Gerhard
)
Metabolic programming of human macrophages in granulomatous skin inflammation
(Applicant
Fabri, Mario
)
Completed projects
Analysis of the function of myeloid cells recruited to sites of tissue damage and the role of VEGF-A in these processes using conditional mutagenesis in mouse models
(Applicant
Eming, Sabine
)
Epidermale Homeostase und Bindegewebsmetabolismus in Papillomvirus-induzierten Hauttumoren
(Applicant
Pfister, Herbert
)
Functions of rac and p65 PAK in the maintenance of the epidermal barrier and in the pathogenesis of skin desease.
(Applicant
Haase, Ingo
)
Identification and characterization of L. major T cell epitopes based on quantitative proteomics
(Applicants
von Stebut-Borschitz, Ruth Esther
;
Tenzer, Stefan
)
Influence of certain forms of DNA-damage and DNA repair on terminal differentiation and aging of human dermal fibroblasts
(Applicant
Herrmann, Gernot Stefan
)
Interaktion autoaggressiver T- und B-Zellen beim Pemphigoid und Pemphigus
(Applicants
Hertl, Michael
;
Hunzelmann, Nicolas
)
Molecular basis of cellular senescence of skin cells in response to UV-induced DNA damage and its consequences
(Applicant
Krieg, Thomas
)
Rac, Phosphoinositide dependent kinase- and Phosphatidylinositol 3-kinase mediated regulation of epidermal repair and tumour formation
(Applicant
Haase, Ingo
)
Relevance of mechanical forces, mediated by integrin-collagen interaction for fibroblast gene expression in healthy and fibrotic skin
(Applicant
Krieg, Thomas
)
Role and therapeutic potential of different skin and lymph node-resident dendritic cell subsets to control cutaneous leishmaniasis in mice
(Applicant
von Stebut-Borschitz, Ruth Esther
)
Role of Integrin-linked kinase in skin homeostasis and carcinogenesis
(Applicant
Wickström, Ph.D., Sara A.
)
Role of the basement membrane proteins nidogen-1 and -2 in skin physiology and pathology
(Applicant
Nischt, Roswitha
)
Role of the extracellular matrix protein COMP in skin fibrosis - localized scleroderma as a model disease
(Applicant
Krieg, Thomas
)
Spezifische und überlappende Funktionen der Kollagen-bindenden Integrinrezeptoren in der Haut
(Applicant
Eckes, Beate
)
Studies on the role of Langerhans cell-dependent factors on Th cell iummune responses in cutaneous Leishmaniose and contact allergy
(Applicant
von Stebut-Borschitz, Ruth Esther
)
The role of XIAP and XIAP-antagonization through mitochondria in melanoma metastasis
(Applicants
Kashkar, Hamid
;
Mauch, Cornelia
)
Untersuchungen zur Bedeutung der Neuropiline und Semaphorine für Physiologie und Pathologie der Haut
(Applicant
Kurschat, Peter Heinz Richard
)
Untersuchungen zu Regulations- und Interaktionsvorgängen in der Basalmembranzone der Haut mit Hilfe eines induzierbaren und gewebespezifischen Laminin Maus-Knockout-Modells
(Applicant
Arin, Meral Julia
)
Priority Programmes
Completed projects
Characterization of phenotype and function of innate lymphoid cells in cutaneous leishmaniasis
(Applicant
von Stebut-Borschitz, Ruth Esther
)
Die Rolle von Zell-Zell- und Zell-Matrix-Interaktionen bei der Synthese und Aktivierung von MMP-2 und MMP-9 in epidermalen Tumorzellen in vitro und in vivo
(Applicant
Nischt, Roswitha
)
Functional characterization of cell-specific differences of L. major-containing phagolysosomes in macrophages and dendritic cells
(Applicants
von Stebut-Borschitz, Ruth Esther
;
Tenzer, Stefan
)
The role of mast cells for directing T cell-dependent immunity in cutaneous leishmaniasis
(Applicant
von Stebut-Borschitz, Ruth Esther
)
Research Fellowships
Completed projects
CD1a- und MHC Klasse II-abhängige Prozessierung und Präsentation von bakteriellen Nicht-Proteinantigenen
(Applicant
Fabri, Mario
)
Untersuchungen zur Bedeutung der VEGF- und Semaphorin-Rezeptoren Neuropilin-1 und -2 für die Tumorprogression am Beispiel des malignen Melanoms
(Applicant
Kurschat, Peter Heinz Richard
)
Collaborative Research Centres
Current projects
Control of macrophage cell death in skin homeostasis and repair
(Project Head
Eming, Sabine
)
Mechanisms controlling Th17 and regulatory T cells in the anti-Leishmania response
(Project Heads
von Stebut-Borschitz, Ruth Esther
;
Waisman, Ari
)
Role of mitochondria in the regulation of myeloid cell function in skin homeostasis and repair
(Project Head
Eming, Sabine
)
Completed projects
Analyse der Interaktion von Leishmania major mit epidermalen Langerhanszellen/dendritischen Zellen
(Project Head
von Stebut-Borschitz, Ruth Esther
)
Die Bedeutung dendritischer Zellen für die genetisch bedingte Entwicklung von charakteristischen T-Helfer Immunantworten in inflammatorischen, allergischen und autoimmunologischen Erkrankungen
(Project Head
von Stebut-Borschitz, Ruth Esther
)
Functions of the inflammatory response in tissue repair
(Project Head
Eming, Sabine
)
Integrated Research Training Group "Molecular mechanisms regulating skin homeostasis"
(Project Heads
Iden, Sandra
;
Krieg, Thomas
)
Morphological Service Project - Characterization of tissues and transgenic model systems
(Project Heads
Krieg, Thomas
;
Schirmacher, Peter
;
Wickenhauser, Claudia
)
New functions of neuropilins and semaphorins in skin
(Project Head
Kurschat, Peter Heinz Richard
)
Pathophysiology of skin ageing and ageing-associated ulcerative dermatitis in mice
(Project Heads
Krieg, Thomas
;
Partridge, Linda
)
Receptor-mediated L. major pathogen recognition and activation of dendritic cells
(Project Head
von Stebut-Borschitz, Ruth Esther
)
Regulation of skin inflammation by epidermal keratinocytes
(Project Head
Haase, Ingo
)
Role of basement membrane proteins in skin morphogenesis and homeostasis
(Project Heads
Krieg, Thomas
;
Nischt, Roswitha
)
Role of collagen-binding integrin receptors for cellular communication and homeostasis in the skin
(Project Heads
Eckes, Beate
;
Krieg, Thomas
)
Role of collagen integrin receptors in skin
(Project Heads
Eckes, Beate
;
Krieg, Thomas
)
Role of MMP-14 in connective tissue homeostasis and tumour invasion
(Project Heads
Mauch, Cornelia
;
Zigrino, Ph.D., Paola
)
Role of MT1-MMP in wound healing
(Project Head
Mauch, Cornelia
)
Role of the basement membrane proteins nidogen-1 and nidogen-2 for skin physiology and pathology
(Project Head
Nischt, Roswitha
)
SFB 589: Molecular basis of structural and functional barriers in the skin
(Spokesperson
Krieg, Thomas
)
SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
(Spokespersons
Krieg, Thomas
;
Niessen, Carien
)
Standardisation of cell culture and mouse models
(Project Heads
Haase, Ingo
;
Mauch, Cornelia
;
Pfister, Herbert
;
Smyth, Neil R.
)
The functional crosstalk between mitochondria and inhibitor of apoptosis proteins (IAPs) during melanoma progression
(Project Heads
Kashkar, Hamid
;
Mauch, Cornelia
)
The role of laminin 5 in skin homeostasis and wound healing
(Project Head
Arin, Meral Julia
)
The role of Rac1 und PAK1 in dthe maintenance and repair of the qpidermal barrier
(Project Head
Haase, Ingo
)
Translational Skin Disease Platform
(Project Heads
Helbig, Doris
;
Mauch, Cornelia
)
Ultrastructural and cell biological service project
(Project Heads
Bloch, Wilhelm
;
Mauch, Cornelia
;
Niessen, Carien
)
UVA-irradiation- and photosensitizer-induced DNA damage: Analysis of activation of P13-kinase-like kinases and their downstream targets in human skin cells
(Project Head
Herrmann, Gernot Stefan
)
Vitamin D regulation of the skin innate immune response
(Project Head
Fabri, Mario
)
Zentrale Aufgaben des Sonderforschungsbereichs
(Project Heads
Krieg, Thomas
;
Niessen, Carien
)
Zentraler Zuständigkeitsbereich Versuchstiereinrichtung
(Project Head
von Stebut-Borschitz, Ruth Esther
)
Zentrale Verwaltungsaufgaben für den SFB
(Project Head
Krieg, Thomas
)
CRC/Transregios
Completed projects
Orchestrating innate immune responses in leishmaniasis - the role of cutaneous DC subtypes
(Project Head
von Stebut-Borschitz, Ruth Esther
)
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
Clusters of Excellence (ExStra)
Current projects
EXC 2030: CECAD - Excellent in Aging Research
(Spokespersons
Benzing, Thomas
;
Hoppe, Thorsten
;
Niessen, Carien
)
Clusters of Excellence
Completed projects
EXC 229: Cellular Stress Responses in Aging-Associated Diseases
(Spokesperson
Brüning, Jens Claus
)
Additional Information
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