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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Hautklinik Mainz
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Fellowships
Completed projects
Die Rolle von Hitzeschockproteinen (HSP) für T-Zell-vermittelte Reaktionen bei der atopischen Dermatitis
(Applicant
Wittmann, Miriam
)
T cell receptor signaling-responsive protein nanogels for the T cell-mediated treatment of solid liver tumors
(Applicant
Fichter, Michael
)
Research Grants
Current projects
From altered skin signature to Lupus: understanding early events in cutaneous Lupus inflammation with regard to disease or health outcome
(Applicant
Wittmann, Miriam
)
Modulation of immunological processes by KSRP
(Applicants
Bros, Matthias
;
Pautz, Andrea
)
Role of beta-2 integrins on immunoregulatory cell types for tumor immune evasion
(Applicant
Grabbe, Stephan
)
The role of monocyte reprogramming in chronic venous thrombosis
(Applicant
Zare-Shahneh, Ph.D., Fatemeh
)
Completed projects
Analyse der menschlichen Immuantwort auf Allergen-Proteine, Allergen-DNA und Adjuvanten mit Hilfe dendritischer Zellen
(Applicant
Saloga, Joachim
)
Analysis of the interaction between invariant natural killer T cells, intestinal microbes and microbial metabolites to prevent allergic airway and intestinal inflammation
(Applicants
Saloga, Joachim
;
Schuppan, Detlef
)
Analysis of the modulation of allergic immune responses in an establihed humanized mouse model
(Applicant
Bellinghausen, Iris
)
Die Rolle von Virus-infizierten Dendritischen Zellen bei der Induktion einer Retrovirus-induzierten Immunsuppression
(Applicants
Dittmer, Ulf
;
Grabbe, Stephan
)
Hepsin cleavable nanocapsules for precision medicine in prostate carcinoma (HEPSIN-NANOLYSIS
(Applicants
Crespy, Daniel
;
Mailänder, Volker
;
Wittig, Rainer
)
Interaction of nanoparticles with cellular compartments and proteins
(Applicant
Mailänder, Volker
)
In vivo-Modulation der Funktion dendritischer Zellen mit Hilfe transgener Mausmodelle
(Applicant
Grabbe, Stephan
)
Modulation allergenspezifischer Immunreaktionen durch IDO-Gentransfer
(Applicant
Sudowe, Stephan
)
Regulation der IgE-Produktion durch CD4-CD8- doppelt negative T-Zellen
(Applicant
Reske-Kunz, Angelika B.
)
Signals in dendritic cells during the induction of allergic Th2-dominated immune responses
(Applicant
Saloga, Joachim
)
The pathogenetic role of kerationocytes in cutaneous lupus erythematosus
(Applicant
Wittmann, Miriam
)
Untersuchungen zur Entwicklung von regulatorischen T-Zellen im Verlauf der Interaktion mit dendritischen Zellen mittels mikroskopischer Lebendzell-Analyse
(Applicants
Grabbe, Stephan
;
Reske-Kunz, Angelika B.
)
Collaborative Research Centres
Current projects
Central tasks
(Project Heads
Grabbe, Stephan
;
Zentel, Rudolf
)
Development and testing of nanoparticles to eliminate the cAMP-mediated immune-suppression in the malignant melanoma
(Project Heads
Barz, Matthias
;
Becker, Christian
;
Bopp, Tobias
)
From nanomaterial surface to function - multifunctional PEGylation, targeting and in vivo proteomics
(Project Heads
Frey, Holger
;
Mailänder, Volker
;
Tenzer, Stefan
)
Induction of intrahepatic anti-tumor immunity by addressing dendritic cells and reprogramming protolerogenic non-parenchymal cell populations
(Project Heads
Bros, Matthias
;
Gehring, Stephan
;
Landfester, Katharina
)
Integrated Research Training Group
(Project Heads
Grabbe, Stephan
;
Zentel, Rudolf
)
Microscopic characterization of nanocarriers in biological environments - from extracellular behavior to intracellular trafficking and immunomodulator release
(Project Heads
Koynov, Ph.D., Kaloian
;
Lieberwirth, Ingo
;
Mailänder, Volker
)
Modulation of the tumor microenvironment by addressing inhibitory (immune) cells via time-programmed and self-regulating liposome
(Project Heads
Helm, Mark
;
Tüttenberg, Andrea Renate
;
Walther, Andreas
)
Nano-particular mRNA-carrier systems to reprogram different immune-cell populations
(Project Heads
Barz, Matthias
;
Langguth, Peter
;
Sahin, Ugur
)
Polymer-mediated tumor immunotherapy via in situ activation of antigen-presenting cells
(Project Heads
Grabbe, Stephan
;
Nuhn, Lutz
;
Schild, Hansjörg
)
SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
(Spokesperson
Grabbe, Stephan
)
Therapy of primary and secondary liver tumors by addressing tolerance-inducing M2 macrophages using immunomodulating nanoparticles
(Project Heads
Nuhn, Lutz
;
Schuppan, Detlef
;
Tüttenberg, Andrea Renate
;
Zentel, Rudolf
)
Tumor-specific immunization by transcutaneous vaccination: Preclinical and clinical development of drug forms for adjuvant therapy of Merkel cell carcinoma
(Project Heads
Grabbe, Stephan
;
Langguth, Peter
;
Radsak, Markus P.
)
Completed projects
Analyse der Genexpression und Regulation während der Entstehung und Hemmung der humanen allergischen Immunantwort
(Project Head
Saloga, Joachim
)
Analyse von regulatorischen T-Zellen aus Melanompatienten und ihre funktionelle Modulation durch konditionierte dendritische Zellen
(Project Head
Jonuleit, Helmut
)
Bedeutung von ß2-Integrinen für die Antigenpräsentation und die Induktion von T Zell-vermittelten Immunantworten
(Project Head
Grabbe, Stephan
)
Funktionalität, Kinetik und Dynamik der Interaktion zwischen T Lymphozyten und Antigenpräsentierenden Zellen
(Project Head
Grabbe, Stephan
)
Funktionelle Charakterisierung humaner regulatorischer T-Zellen
(Project Head
Jonuleit, Helmut
)
Gentherapeutische Verfahren zur Inhibition systemischer und lokaler allergenspezifischer Immunantworten
(Project Head
Sudowe, Stephan
)
Interaktionen von dendritischen Antigen-präsentierenden Zellen mit Komponenten der extrazellulären Matrix bei Migration und Antigenpräsentation
(Project Head
Grabbe, Stephan
)
Molekulare Analysen zur Identität und funktionellen Bedeutung der Zielstrukturen und Kopplungsmechanismen von Kontaktallergenen
(Project Head
Becker, Detlef
)
Proteins on nanocarriers: from the stealth effect to active targeting in vivo
(Project Heads
Mailänder, Volker
;
Tenzer, Stefan
;
Weil, Tanja
)
RNA-loaded functionalized nanoparticles for inhibition of tumour-associated regulatory T cells and antigen loading of human dendritic cells
(Project Heads
Helm, Mark
;
Jonuleit, Helmut
)
SFB 548: Analysis and modulation of allergic and autoimmunologic diseases
(Spokesperson
Galle, Peter R.
)
Synthetic control of morphology and function in peptide based carrier systems
(Project Heads
Barz, Matthias
;
Weil, Tanja
)
The impact of IL-12 family cytokines on keratinocyte T cell interaction in eczema
(Project Heads
Werfel, Thomas
;
Wittmann, Miriam
)
Transcriptional addressing of dendritic cells (DCs) with the help of an hPFscn1 derived promotor using DC-addressing polymers for tumortherapy
(Project Heads
Bros, Matthias
;
Wagner, Ernst
;
Zentel, Rudolf
)
Transfection of tumor-reactive T cells using RNA loaded nanocapsules
(Project Heads
Mailänder, Volker
;
Wölfel, Thomas Johann
)
Zentrale Aufgaben des Sonderforschungsbereichs
(Project Heads
Galle, Peter R.
;
Knop, Jürgen
)
Priority Programmes
Completed projects
Biokompatible magnetische Partikel: Herstellung und Charakterisierung polymerverkapselter, superparamagnetischer Nanopartikel (für den Teilbereich "Entwicklung und Herstellung neuartiger Ferrofluide")
(Applicant
Landfester, Katharina
)
Interaction of nanoparticles with cellular compartments and proteins
(Applicants
Landfester, Katharina
;
Mailänder, Volker
;
Nienhaus, Gerd Ulrich
;
Simmet, Thomas
)
The role of mast cells for directing T cell-dependent immunity in cutaneous leishmaniasis
(Applicant
von Stebut-Borschitz, Ruth Esther
)
CRC/Transregios
Current projects
Targeting CDK4/6 for the treatment of skin diseases
(Project Heads
Gehringer, Matthias
;
Hailfinger, Stephan
;
Kramer, Daniela
)
The role of CD18 and regulatory T cells in skin inflammation
(Project Heads
Bopp, Tobias
;
Grabbe, Stephan
)
The role of non-canonical NF-κB signaling in Treg cells in tissue homeostasis and disease
(Project Heads
Kramer, Daniela
;
Waisman, Ari
)
Completed projects
Analysis of Differential Gene Expression and Signal Transduction in Human Regulatory T Cells
(Project Heads
Jonuleit, Helmut
;
Ohlemacher, Sabine
;
Tüttenberg, Andrea Renate
)
Functional relevance of the Rho signaling inhibitor Myosin 9B and downstream cytoskeletal proteins for cutaneous dendritic cell populations
(Project Heads
Bros, Matthias
;
Grabbe, Stephan
)
Repression of Gene Expression in T-Lymphocytes Mediated by Multi-Protein Complexes of Chosen Transcription Factors
(Project Heads
Berberich-Siebelt, Friederike
;
Jonuleit, Helmut
;
Sickmann, Albert
)
WBP Fellowship
Current projects
The role of T-cell associated chemokines in shaping the tumor immune microenvironment and for the initiation of effective anti-tumor immune responses in malignant melanoma
(Applicant
Haist, Maximilian
)
Research Units
Current projects
Deciphering the region-specific distribution and function of dendritic cell populations along the epididymis
(Applicants
Mayer, Johannes U.
;
Pleuger, Christiane
)
FOR 5644: The role of immune cells in the function of the normal and diseased testis and epididymis (‘INFINITE’)
(Spokesperson
Meinhardt, Andreas
)
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
GRK 1441: Regulation of the Allergic Response in Lung and Skin
(Spokesperson
Werfel, Thomas
)
Additional Information
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