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Institution
Universitätsklinikum Hamburg-Eppendorf
Institut für Osteologie und Biomechanik (IOBM)
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Analysis of the molecular and physiological influence of Wnt1 on the skeleton
(Applicant
Yorgan, Timur
)
Analysis of tissue-material characteristics at the bone-magnesium interface built by biodegradable implants
(Applicants
Busse, Björn
;
Wieland, Florian
)
Characterization of the Influence of Mechanical Loading on Load Bearing and non-Load Bearing Bones in the Scull and Locomotive System
(Applicant
von Brackel, Ph.D., Felix
)
Deciphering the physiological function(s) of Panx3, a gene displaying specific expression in bone-forming osteoblasts
(Applicants
Keller, Ph.D., Johannes
;
Schinke, Ph.D., Thorsten
)
Impact of Wnt1 mutation on skeletal remodeling, bone matrix quality, fracture healing and response to mechanical stimulation
(Applicants
Ignatius, Anita
;
Schinke, Ph.D., Thorsten
)
Influence of cold-induced energy expenditure on bone remodeling
(Applicants
Heeren, Jörg
;
Schinke, Ph.D., Thorsten
)
Molecular role of PIEZO1 in endochondral ossification
(Applicants
Ignatius, Anita
;
Schinke, Ph.D., Thorsten
)
The role of osteocytes in bone regeneration using a murine calvarial defect model
(Applicant
Jähn-Rickert, Ph.D., Katharina
)
The role of Zinc and Zinc-dependent G Protein-coupled Receptor (GPR39) on the structure and composition of bone
(Applicant
Busse, Björn
)
Understanding the cellular and molecular causes of early-onset osteoporosis associated with Enpp1 haploinsufficiency
(Applicant
Oheim, Ralf
)
Completed projects
Analysis of bone quality in the elderly: effects of immobilization and type 2 diabetes mellitus as age-related risk factors
(Applicant
Busse, Björn
)
Analysis of bone remodeling in mouse models of mucopolysaccharidosis
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
Bedeutung des Heparin-bindenden Polypeptids Midkine in der Regulation der Knochenmasse und der Frakturheilung
(Applicants
Amling, Michael
;
Ignatius, Anita
)
Cellular and molecular characterization of a mouse model for WNT1-related autosomal recessive osteogenesis imperfecta
(Applicant
Yorgan, Timur
)
Characterizing the bone anabolic function of Wnt1
(Applicants
Amling, Michael
;
David, Ph.D., Jean-Pierre
)
Coding and non-coding genetic variants as the basis for early-onset osteoporosis
(Applicants
Kornak, Uwe
;
Mundlos, Stefan
)
Deciphering the role of Piezo proteins in mechanotransduction of bone cells
(Applicants
Amling, Michael
;
Ignatius, Anita
)
Development of an bioactive preadipocyte loaded fibroin biohybrid for the augmentation of soft tissue defects.
(Applicant
Hanken, Henning
)
Differential influence on bone remodeling by regulators of Wnt-dependent signal transduction
(Applicant
Schinke, Ph.D., Thorsten
)
Engineering aspects for tissue engineering of hyaline cartilage
(Applicants
Amling, Michael
;
Pörtner, Ralf
)
Functional Imaging of Osteocyte Autophagy, Senescence and Apoptosis in Human Bone
(Applicant
Jähn-Rickert, Ph.D., Katharina
)
Histologische, zelluläre und molekulare Charakterisierung Osteopetrose-assoziierter Pathologien
(Applicant
Amling, Michael
)
Ingenieurtechnische Aspekte bei der Züchtung von künstlichem Gelenkknorpel
(Applicants
Amling, Michael
;
Becker, Thomas
;
Pörtner, Ralf
)
Molecular control of the bilateral communication between osteoclasts and osteoblasts
(Applicant
Amling, Michael
)
Quantifizierung der Gewebekontamination mit Implantatbestandteilen nach Oberflächenersatz-Endoprothesen mit Metall/Metall-Gleitpaarung
(Applicants
Hahn, Michael
;
Radtke, Martin
)
Regulation der Knochenformation durch Calcitonin
(Applicant
Amling, Michael
)
Regulation of Insulin Sensitivity by Osteoblasts
(Applicant
Luther, Ph.D., Julia
)
Strukturelle Analysen an Knochen genetisch veränderter Mäuse mit der peripheren, quantitativen Computertomographie (pQCT-M)
(Applicant
Eckstein, Felix
)
The role of Notch2-dependent signaling in skeletal remodeling
(Applicant
Schinke, Ph.D., Thorsten
)
The role of plastin-3 in skeletal remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
The role of Wnt1 in posteruptive tooth development
(Applicant
Köhne, Till
)
Untersuchungen zur physiologischen Funktion des Peptidhormons Calcitonin bei der Regulation der Knochendichte
(Applicant
Amling, Michael
)
Vertebral fracture risk: Combined assessment through clinical 2D-osteodensitometry tools and experimental high-resolution micro-CT analyses to pinpoint regional 3D bone quality characteristics
(Applicant
Milovanovic, Ph.D., Petar
)
Zentrale, neuroendokrine Regulation der Knochenmasse
(Applicant
Amling, Michael
)
Research Units
Completed projects
Entwicklung und Charakterisierung eines Osteoporose-Großtiermodells mit Diskonnektion von Hypothalamus und Hypophyse (HPD-Schaf)
(Applicant
Amling, Michael
)
FOR 793: Mechanisms of Fracture Healing and Regeneration in Osteoporotic Bone
(Spokesperson
Amling, Michael
)
Mechanismen der Frakturheilung und Knochenregeneration bei Osteoporose
(Applicant
Amling, Michael
)
Regulation der Knochenformation und Knochenmasse durch Wnt-abhängige Signaltransduktion
(Applicant
Schinke, Ph.D., Thorsten
)
Untersuchung der Frakturheilung bei Hypochlorhydrie-induzierter Osteoporose in Maus und Schwein
(Applicants
Amling, Michael
;
Ignatius, Anita
;
Jakob, Franz
;
Mutschler, Wolf
)
Independent Junior Research Groups
Completed projects
Influence of the ultrastructure on the fracture characteristics of human bone in physiological and pathological conditions
(Applicant
Busse, Björn
)
Clinical Research Units
Current projects
Coordination Funds
(Applicant
Amling, Michael
)
Disease stratification, treatment monitoring and establishment of model systems
(Applicants
Oheim, Ralf
;
Schinke, Ph.D., Thorsten
)
Identification of genetic and molecular causes of hypophosphatasia
(Applicants
Barvencik, Florian
;
Yorgan, Timur
)
KFO 5029: Precision Medicine for Early-Onset Low Bone Mineral Density Disorders
(Spokesperson
Amling, Michael
)
Completed projects
Influence of PSC on skeletal remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
KFO 306: Primär Sklerosierende Cholangitis
(Spokesperson
Lohse, Ansgar W.
)
Heisenberg Professorships
Completed projects
Biomedical Sciences and Osteology
(Applicant
Busse, Björn
)
Heisenberg Grants
Completed projects
Biomedical Sciences and Osteology
(Applicant
Busse, Björn
)
Priority Programmes
Current projects
Investigating the role of osteocyte steatosis as underlying mechanisms of the impaired osteocyte network due to bone metastasis
(Applicants
Busse, Björn
;
Rauner, Martina
)
Completed projects
Analysis of early immune responses and the role of mast cells in fracture healing
(Applicants
Dudeck, Anne
;
Ignatius, Anita
)
Characterization of the impact of bone-seeking tumors on the osteocyte network and the osteocyte-mediated regulation of bone turnover
(Applicants
Busse, Björn
;
Raum, Kay
;
Rauner, Martina
)
Core Facility: Morphology - Imaging - Skeletal Characterization
(Applicant
Amling, Michael
)
Crosstalk between inflammation, bone destruction and new bone formation in patients with ankylosing spondylitis
(Applicant
Syrbe, Uta
)
Heparan sulfate in Degenerating Joint Diseases
(Applicant
Vortkamp, Andrea
)
Influence of the skeletal remodeling status on tumor cell dissemination and metastatic outgrowth
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
Relevance of osteal macrophages in bone remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
Role for the bone environment in regulating immune responses
(Applicant
David, Ph.D., Jean-Pierre
)
The role of CXCR2-ligands for neutrophil mobilization from the bone marrow to peripheral sites
(Applicants
Gunzer, Matthias
;
Waisman, Ari
)
Research Fellowships
Completed projects
Einfluss der Mineralisation auf die Knochenqualität
(Applicant
Busse, Björn
)
Major Research Instrumentation
Completed projects
Contact X-ray Cabinet
Digitaler Volumen Tomograph
high-resolution, peripheral, quantitative computed tomography scanner - in vivo MicroCT Scanner
Kombiniertes Ramanspektroskop-Rasterelektronenmikroskop
Mikro-CT
Collaborative Research Centres
Completed projects
The role of AP-1 signalling in the pathology of bone remodelling
(Project Head
David, Ph.D., Jean-Pierre
)
Additional Information
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