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Institution
Universität Leipzig
Medizinische Fakultät
Rudolf-Schönheimer-Institut für Biochemie
Address
Johannisallee 30
04103 Leipzig
Deutschland
GERiT
This institution in GERiT
04103 Leipzig
Projects
Research Grants
Current projects
Identifying a paracrine fibroblast-derived factor that stimulates fetal alveolar cells, thus potentially enhancing perinatal lung transition.
(Applicants
Hoffmann, Ralf
;
Thome, Ulrich H.
)
Proteolytic processing of adhesion G-protein coupled receptors through proteases
(Applicant
Langenhan, Tobias
)
Completed projects
A High-coverage Ancient Genome for Analyzing Arctic Adaptation Mechanisms – the Steller’s Sea Cow Case
(Applicants
Hofreiter, Michael
;
Schöneberg, Torsten
)
Analyse der physiologischen und pathophysiologischen Relevanz des Chemoattractant-Rezeptors GPR33
(Applicant
Schöneberg, Torsten
)
Aufklärung der molekularen Mechanismen der Regulation der Expression der Hirn-Phosphofruktokinase
(Applicant
Bigl, Marina
)
Die 14-3-3 Proteine von Chlamydomonas reinhardtii
(Applicant
Voigt, Jürgen
)
Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions
(Applicants
Beck-Sickinger, Annette G.
;
Schöneberg, Torsten
)
Function and properties of the adhesion-G-protein-coupled receptor latrophilin in the fruit fly Drosophila melanogaster
(Applicant
Langenhan, Tobias
)
Neue Transkriptionsfaktoren und ihre Interaktionen bei der Regulation der Expression der Glutamin Synthetase in verschiedenen Geweben
(Applicant
Gaunitz, Frank
)
Physiologie des orphan G-Protein-gekoppelten Rezeptors GPR34
(Applicant
Schöneberg, Torsten
)
Subcellular distribution, trafficking and signal transduction of G protein-coupled receptors for energy metabolites
(Applicant
Stäubert, Claudia
)
The activation mechanism of glycoprotein hormone receptors
(Applicant
Brüser, Antje
)
The Dark Matter of the Immunopetidome: Cryptic Peptides as Tumor Antigens in Melanoma.
(Applicants
Horn, Susanne
;
Schilling, Bastian
;
Schlosser, Andreas
)
V2-Vasopressin-Rezeptor-defiziente Mäuse als pathophysiologisches und therapeutisches Modell
(Applicant
Schöneberg, Torsten
)
Zellzyklusabhängige Modulation der Ornithin-Decarboxylase-Aktivität und ihre Bedeutung für die Zellzyklusprogression
(Applicant
Voigt, Jürgen
)
Heisenberg Fellowships
Completed projects
Funktion und Pathophysiologie von G-Protein-gekoppelten Rezeptoren
(Applicant
Schöneberg, Torsten
)
Research Units
Completed projects
Coordination Funds
(Applicant
Langenhan, Tobias
)
FOR 748: Neuronal and Glial P2 Receptors; Molecular Basis and Functional Significance
(Spokesperson
Schöneberg, Torsten
)
FOR 2149: Elucidation of Adhesion-GPCR Signalling
(Spokesperson
Langenhan, Tobias
)
Functional analysis of the adhesion GPCR class in Drosophila
(Applicants
Langenhan, Tobias
;
Scholz, Nicole
)
Functional specificity of ADP-(P2Y12)-like receptors
(Applicant
Schulz, Angela
)
Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction
(Applicants
Kittel, Robert J.
;
Langenhan, Tobias
)
Structural studies on extracellular adhesion GPCR signaling
(Applicants
Schöneberg, Torsten
;
Sträter, Norbert
)
The role of the Adhesion G protein-coupled receptor GPR133/ADGRD1 in the mechano-sensitive tissues heart and bone
(Applicant
Liebscher, Ines
)
Z-Project (coordination and central funds)
(Applicant
Schöneberg, Torsten
)
Priority Programmes
Completed projects
Trace amine-associated receptors (TAAR) as targets for thyronamines
(Applicant
Stäubert, Claudia
)
Heisenberg Professorships
Completed projects
Physiology and pathophysiology of mechanoceptive signalling pathways
(Applicant
Langenhan, Tobias
)
Collaborative Research Centres
Current projects
Dynamic modulation of adhesion GPCR function through complex formation
(Project Heads
Langenhan, Tobias
;
Scholz, Nicole
)
Enzymology of autoproteolysis and signaling function of the GAIN domain in adhesion GPCRs
(Project Heads
Langenhan, Tobias
;
Sträter, Norbert
)
Integrated Research Training Group
(Project Heads
Körner, Antje
;
Schöneberg, Torsten
)
Mechano-sensitive adhesion GPCR in adipose tissue
(Project Heads
Huster, Daniel
;
Liebscher, Ines
;
Schiller, Jürgen
;
Schöneberg, Torsten
)
Signal integration and specification of adhesion GPCRs
(Project Head
Liebscher, Ines
)
Structure-, localization-, metabolism- and ligand-dependent signaling bias of metab-olite-sensing GPCRs
(Project Head
Stäubert, Claudia
)
Structures of adhesion GPCR by cryo-electron microscopy
(Project Heads
Scheerer, Patrick
;
Schöneberg, Torsten
;
Spahn, Christian M. T.
)
Targeting of central peptide receptors via nasal ligand application to modulate food intake
(Project Heads
Bechmann, Ingo
;
Beck-Sickinger, Annette G.
;
Klöting-Blüher, Nora
;
Schulz, Angela
)
The neglected receptor N terminus - signal filter, signal integration, trans-signaling of adhesion GPCR
(Project Heads
Prömel, Simone
;
Schöneberg, Torsten
)
Completed projects
Circadian plasticity at synapses of Drosophila melanogaster
(Project Heads
Kittel, Robert J.
;
Langenhan, Tobias
)
Conformational changes in intracellular domains of G protein-coupled receptors
(Project Head
Schöneberg, Torsten
)
Integrated Research Training Group
(Project Heads
Schöneberg, Torsten
;
Stubbs, Milton T.
)
Structure and allosteric conformations of eucaryotic 6-phosphofructokinases
(Project Heads
Schöneberg, Torsten
;
Sträter, Norbert
)
Struktur- und Funktionsanalyse einer neuen Gruppe von heptahelikalen Nukleotid-Rezeptoren
(Project Heads
Schultz, Günter
;
Schöneberg, Torsten
)
WBP Fellowship
Current projects
Elucidating the molecular mechanisms by which mammalian Latrophilin Adhesion GPCRs function in synapse formation in vivo
(Applicant
Matus, Daniel
)
CRC/Transregios
Completed projects
FRET-based monitoring of Adhesion class G protein-coupled receptor activity
(Project Head
Langenhan, Tobias
)
Clinical Research Units
Current projects
Building health intelligence with complex data on tumor cell states and therapy resistance
(Applicants
Horn, Susanne
;
Schadendorf, Dirk
)
KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE): pre-clinical and translational advance of the CRU 337
(Spokesperson
Schadendorf, Dirk
)
Research Training Groups
Completed projects
GRK 1097: Interdisciplinary Approaches in Cellular Neurosciences (InterNeuro)
(Spokesperson
Reichenbach, Andreas
)
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