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Institution
Universität Leipzig
Medizinische Fakultät
Rudolf-Schönheimer-Institut für Biochemie
Address
Johannisallee 30
04103 Leipzig
Deutschland
GERiT
This institution in GERiT
04103 Leipzig
Projects
Research Grants
Current projects
Analysis of the signaling pathway of the adhesion GPCR homolog CG15744/Remoulade in Drosophila
(Applicant
Blanco Redondo, Ph.D., Beatriz
)
Identifying a paracrine fibroblast-derived factor that stimulates fetal alveolar cells, thus potentially enhancing perinatal lung transition.
(Applicants
Hoffmann, Ralf
;
Thome, Ulrich H.
)
Proteolytic processing of adhesion G-protein coupled receptors through proteases
(Applicant
Langenhan, Tobias
)
Completed projects
A High-coverage Ancient Genome for Analyzing Arctic Adaptation Mechanisms – the Steller’s Sea Cow Case
(Applicants
Hofreiter, Michael
;
Schöneberg, Torsten
)
Analyse der physiologischen und pathophysiologischen Relevanz des Chemoattractant-Rezeptors GPR33
(Applicant
Schöneberg, Torsten
)
Aufklärung der molekularen Mechanismen der Regulation der Expression der Hirn-Phosphofruktokinase
(Applicant
Bigl, Marina
)
Die 14-3-3 Proteine von Chlamydomonas reinhardtii
(Applicant
Voigt, Jürgen
)
Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions
(Applicants
Beck-Sickinger, Annette G.
;
Schöneberg, Torsten
)
Function and properties of the adhesion-G-protein-coupled receptor latrophilin in the fruit fly Drosophila melanogaster
(Applicant
Langenhan, Tobias
)
Neue Transkriptionsfaktoren und ihre Interaktionen bei der Regulation der Expression der Glutamin Synthetase in verschiedenen Geweben
(Applicant
Gaunitz, Frank
)
Physiologie des orphan G-Protein-gekoppelten Rezeptors GPR34
(Applicant
Schöneberg, Torsten
)
Subcellular distribution, trafficking and signal transduction of G protein-coupled receptors for energy metabolites
(Applicant
Stäubert, Claudia
)
The activation mechanism of glycoprotein hormone receptors
(Applicant
Brüser, Antje
)
The Dark Matter of the Immunopetidome: Cryptic Peptides as Tumor Antigens in Melanoma.
(Applicants
Horn, Susanne
;
Schilling, Bastian
;
Schlosser, Ph.D., Andreas
)
V2-Vasopressin-Rezeptor-defiziente Mäuse als pathophysiologisches und therapeutisches Modell
(Applicant
Schöneberg, Torsten
)
Zellzyklusabhängige Modulation der Ornithin-Decarboxylase-Aktivität und ihre Bedeutung für die Zellzyklusprogression
(Applicant
Voigt, Jürgen
)
Heisenberg Fellowships
Completed projects
Funktion und Pathophysiologie von G-Protein-gekoppelten Rezeptoren
(Applicant
Schöneberg, Torsten
)
Research Units
Completed projects
Coordination Funds
(Applicant
Langenhan, Tobias
)
FOR 748: Neuronal and Glial P2 Receptors; Molecular Basis and Functional Significance
(Spokesperson
Schöneberg, Torsten
)
FOR 2149: Elucidation of Adhesion-GPCR Signalling
(Spokesperson
Langenhan, Tobias
)
Functional analysis of the adhesion GPCR class in Drosophila
(Applicants
Langenhan, Tobias
;
Scholz, Nicole
)
Functional specificity of ADP-(P2Y12)-like receptors
(Applicant
Schulz, Angela
)
Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction
(Applicants
Kittel, Robert J.
;
Langenhan, Tobias
)
Structural studies on extracellular adhesion GPCR signaling
(Applicants
Schöneberg, Torsten
;
Sträter, Norbert
)
The role of the Adhesion G protein-coupled receptor GPR133/ADGRD1 in the mechano-sensitive tissues heart and bone
(Applicant
Liebscher, Ines
)
Z-Project (coordination and central funds)
(Applicant
Schöneberg, Torsten
)
Priority Programmes
Completed projects
Trace amine-associated receptors (TAAR) as targets for thyronamines
(Applicant
Stäubert, Claudia
)
Heisenberg Professorships
Completed projects
Physiology and pathophysiology of mechanoceptive signalling pathways
(Applicant
Langenhan, Tobias
)
WBP Position
Current projects
The influence of cell type-specific G-protein activity on GPCR-mediated signal transduction in adipose tissue (patho)physiology
(Applicant
Kaczmarek, Isabell
)
Collaborative Research Centres
Current projects
Dynamic modulation of adhesion GPCR function through complex formation
(Project Heads
Langenhan, Tobias
;
Scholz, Nicole
)
Enzymology of autoproteolysis and signaling function of the GAIN domain in adhesion GPCRs
(Project Heads
Langenhan, Tobias
;
Sträter, Norbert
)
Signal integration and specification of adhesion GPCRs
(Project Head
Liebscher, Ines
)
Structure-, localization-, metabolism- and ligand-dependent signaling bias of metab-olite-sensing GPCRs
(Project Head
Stäubert, Claudia
)
Structures of adhesion GPCR by cryo-electron microscopy
(Project Heads
Scheerer, Patrick
;
Schöneberg, Torsten
;
Spahn, Christian M. T.
)
The neglected receptor N terminus - signal filter, signal integration, trans-signaling of adhesion GPCR
(Project Heads
Prömel, Simone
;
Schöneberg, Torsten
)
Completed projects
Circadian plasticity at synapses of Drosophila melanogaster
(Project Heads
Kittel, Robert J.
;
Langenhan, Tobias
)
Conformational changes in intracellular domains of G protein-coupled receptors
(Project Head
Schöneberg, Torsten
)
Integrated Research Training Group
(Project Heads
Schöneberg, Torsten
;
Stubbs, Milton T.
)
Integrated Research Training Group
(Project Heads
Körner, Antje
;
Schöneberg, Torsten
)
Mechano-sensitive adhesion GPCR in adipose tissue
(Project Heads
Huster, Daniel
;
Liebscher, Ines
;
Schiller, Jürgen
;
Schöneberg, Torsten
)
Structure and allosteric conformations of eucaryotic 6-phosphofructokinases
(Project Heads
Schöneberg, Torsten
;
Sträter, Norbert
)
Struktur- und Funktionsanalyse einer neuen Gruppe von heptahelikalen Nukleotid-Rezeptoren
(Project Heads
Schultz, Günter
;
Schöneberg, Torsten
)
Targeting of central peptide receptors via nasal ligand application to modulate food intake
(Project Heads
Bechmann, Ph.D., Ingo
;
Beck-Sickinger, Annette G.
;
Klöting-Blüher, Nora
;
Schulz, Angela
)
CRC/Transregios
Completed projects
FRET-based monitoring of Adhesion class G protein-coupled receptor activity
(Project Head
Langenhan, Tobias
)
Clinical Research Units
Current projects
Building health intelligence with complex data on tumor cell states and therapy resistance
(Applicants
Horn, Susanne
;
Schadendorf, Dirk
)
KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE): pre-clinical and translational advance of the CRU 337
(Spokesperson
Schadendorf, Dirk
)
Research Training Groups
Current projects
GRK 3102: Molecular tuning of neuronal communication - NeuroTune
(Spokesperson
Kittel, Robert J.
)
Completed projects
GRK 1097: Interdisciplinary Approaches in Cellular Neurosciences (InterNeuro)
(Spokesperson
Reichenbach, Andreas
)
Clusters of Excellence (ExStra)
Current projects
EXC 3105: Leipzig Center of Metabolism (LeiCeM) – Understanding and improving metabolic health
(Spokespersons
Blüher, Ph.D., Matthias
;
Körner, Antje
;
Stumvoll, Michael
)
Additional Information
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