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Universitätsklinikum Hamburg-Eppendorf
Zentrum für Innere Medizin
III. Medizinische Klinik und Poliklinik

Address Martinistraße 52
20251 Hamburg
Deutschland

GERiT This institution in GERiT

20251 Hamburg

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Emmy Noether International Fellowships
- Completed projects
  - Mechanismen dynamischer Schlitzmembranfunktionen
    (Applicant Huber, Tobias B. )
Clinical Research Units
- Completed projects
  - Characterization of inflammatory cells and mediators in human glomerulonephritis
    (Applicant Stahl, Rolf A.K. )
  - Function of chemokine receptors in T cell-mediated glomerulonephritis
    (Applicant Panzer, Ulf )
  - KFO 228: Immunopathogenesis and Therapy of Glomerulonephritis
    (Spokesperson Stahl, Rolf A.K. )
  - KFO 296: Feto-maternal immune cross talk: Consequences for maternal and offspring's health
    (Spokesperson Arck, Petra Clara )
  - Metabolisches Lernen - Wird die Adaptation an wiederholte Hypoglykämien durch glutamaterge Mechanismen vermittelt?
    (Applicant Pais, Isabel )
  - Regulation of the Th17 response in glomerulonephritis
    (Applicant Steinmetz, Oliver Michael )
  - Role of NF-kB in glomerulonephritis
    (Applicant Thaiss, Friedrich )
  - Structural development of the Clinical Research Unit 228
    (Applicant Panzer, Ulf )
  - The Role of mTOR dependent and independent signalling pathways for renal tubular cystogenesis
    (Applicants Huber, Tobias B. ; Reichardt, Wilfried )
Heisenberg Fellowships
- Completed projects
  - Center for Glomerular Disease and Aging (CGDA)
    (Applicant Huber, Tobias B. )
Heisenberg Professorships
- Completed projects
  - Chronische Nierenerkrankungen und Altersforschung
    (Applicant Huber, Tobias B. )
Emmy Noether Independent Junior Research Groups
- Completed projects
  - Dynamische Podozytenfunktion zur Regulation des Nierenfilters
    (Applicant Huber, Tobias B. )
  - Innate lymphoid cells in renal inflammation
    (Applicant Turner, Jan-Eric )
  - Molecular Mechanisms of Membranous Nephropathy – New Avenues Towards an Individualized Therapy
    (Applicant Tomas, Nicola )
Priority Programmes
- Completed projects
  - Tissue-specific mechanisms of ILC2 adaptation and plasticity
    (Applicant Turner, Jan-Eric )
Heisenberg Grants
- Current projects
  - Organ Immunology and Disease Modelling
    (Applicant Bunders, Ph.D., Madeleine )
WBP Return Grant
- Completed projects
  - Rückkehrstipendium
    (Applicant Jaschke, Ph.D., Nikolai Pirmin )
Collaborative Research Centres
- Current projects
  - Decoding of crescent fate in an integrative and translational approach
    (Project Heads Grahammer, Florian ; Puelles, Ph.D., Victor G. ; Zimmermann, Marina )
  - Elucidating principles of kidney and organ involvement in emerging viral infections
    (Project Head Huber, Tobias B. )
  - Function and regulation of systemic and local complement C3 in immune-mediated kidney diseases
    (Project Heads Freiwald, Tilo ; Wiech, Thorsten )
  - Function of effector Treg subsets in glomerulonephritis
    (Project Head Steinmetz, Oliver Michael )
  - Hamburg Glomerulonephritis Registry
    (Project Heads Hoxha, Elion ; Huber, Tobias B. ; Lindenmeyer, Maja ; Wiech, Thorsten )
  - Hereditary lysosomal storage and metabolic diseases in the kidney
    (Project Heads Huber, Tobias B. ; Schumann, Ph.D., Anke )
  - High-dimensional single cell profiling in renal autoimmune diseases
    (Project Heads Bonn, Stefan ; Krebs, Christian ; Panzer, Ulf )
  - Identifying pathways and factors causing primary focal segmental glomerulosclerosis
    (Project Heads Huber, Tobias B. ; Mühlig, Anne Katrin )
  - Impact of maternal immune activation on the interleukin-6/T helper 17 – axis for intestinal tissue development and inflammation in children
    (Project Head Bunders, Ph.D., Madeleine )
  - Impact of purinergic signaling on epithelial cell-adipocyte crosstalk in intestinal inflammation and fibrosis in Crohn’s Disease
    (Project Heads Bunders, Ph.D., Madeleine ; Worthmann, Anna )
  - Innate and innate-like lymphocytes in immune-mediated glomerular diseases
    (Project Heads Bunders, Ph.D., Madeleine ; Turner, Jan-Eric )
  - Innate lymphoid cell development and modulation of cholangiocytes in biliary atresia
    (Project Head Bunders, Ph.D., Madeleine )
  - Management and Coordination of the CRC
    (Project Head Huber, Tobias B. )
  - Mechanisms and function of T cell derived cytokines in crescentic glomerulonephritis
    (Project Head Panzer, Ulf )
  - Mechanisms of Immune-Mediated Tissue Injury
    (Project Heads Harendza, Sigrid ; Panzer, Ulf )
  - Membranous Nephropathy: Pathogenetic Mechanisms and Clinical Implications
    (Project Heads Hoxha, Elion ; Reinhard, Linda )
  - Nanobody-based treatment strategies in glomerulonephritis
    (Project Heads Tomas, Nicola ; Wanner, Nicola )
  - Proteolytic control of immune-mediated kidney diseases
    (Project Head Rinschen, Markus )
  - SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
    (Spokespersons Huber, Tobias B. ; Panzer, Ulf )
  - Spatial decoding of hepatic microenvironments to decipher, diagnose and stratify autoim-mune hepatitis
    (Project Heads Puelles, Ph.D., Victor G. ; Sebode, Marcial ; Zimmermann, Marina )
  - Structural and functional characterization of podocyte antigens in autoantibody-mediated glomerulonephritis
    (Project Heads Hengel, Felicitas E. ; Huber, Tobias B. ; Wilmanns, Ph.D., Matthias )
  - Targeting Th17 cell adaptation in renal autoimmune diseases
    (Project Heads Huber, Samuel ; Krebs, Christian )
  - The (immuno)proteasome as a modifier of podocyte membrane dynamics in membranous nephrophathy
    (Project Heads Köhler, Sybille ; Meyer-Schwesinger, Catherine )
- Completed projects
  - Development of the Glomerular Filter
    (Project Heads Huber, Tobias B. ; Kramer-Zucker, Albrecht )
  - Epigenetic programming of kidney development
    (Project Head Huber, Tobias B. )
  - High-resolution proteomics and functional analyses of the podocyte slit diaphragm and its disease-induced dynamics
    (Project Heads Fakler, Bernd ; Grahammer, Florian )
  - High-resolution structural and global signaling network identification of the NEPH-NEPHRIN protein complex
    (Project Head Huber, Tobias B. )
  - The innate immune response in hypertensive glomerular injury
    (Project Heads Ehmke, Heimo ; Wenzel, Ulrich )
Research Units
- Current projects
  - FOR 2743: Mechanical Stress Protection
    (Spokesperson Höhfeld, Jörg )
  - FOR 5211: Persistent Somatic Symptoms Across Diseases: From Risk Factors to Modification
    (Spokesperson Löwe, Bernd )
  - Mechanical stress protection at the kidney filtration barrier
    (Applicants Benzing, Thomas ; Rinschen, Markus )
  - Predictors of Somatic Symptom Persistence in Patients With Chronic Kidney Disease (RU SOMACROSS)
    (Applicants Huber, Tobias B. ; Shedden Mora, Ph.D., Meike )
Major Research Instrumentation
- Completed projects
  - 5-Laser Flow Cytometer
WBP Fellowship
- Completed projects
  - Pharmacological CBP/p300 histone acetyltransferase inhibition to therapeutically modulate leukocyte biology and promote host defenses
    (Applicant Jaschke, Ph.D., Nikolai Pirmin )
  - The role of IFITM1 and IFITM3 in kidney disease
    (Applicant Dumoulin, Bernhard )
CRC/Transregios
- Current projects
  - Advanced molecular and clinical phenotyping
    (Project Heads Habbig, Sandra ; Huber, Tobias B. ; Lindenmeyer, Maja ; Weber, Lutz T. ; Wiech, Thorsten )
  - Analysis of extracellular vesicles (EVs) in podocyte survival and intercellular communication
    (Project Heads Braun, Fabian ; Krahn, Ph.D., Michael )
  - Deciphering intraglomerular inflammatory signaling in podocyte homeostasis and disease
    (Project Heads Brähler, Sebastian ; Tomas, Nicola )
  - Decoding slit diaphragm stabilization
    (Project Heads Grahammer, Florian ; Puelles, Ph.D., Victor G. )
  - Integrated Research Training Group - PodoSigN-RTG
    (Project Heads Harendza, Sigrid ; Meyer-Schwesinger, Catherine ; Schermer, Bernhard ; Weide, Thomas )
  - Podocyte metabolic signaling
    (Project Heads Huber, Tobias B. ; Wanner, Nicola )
  - Role of amino acid metabolism at the kidney filtration barrier
    (Project Heads Rinschen, Markus ; Schmidt, Insa Marie )
  - Unravel the mechanotransduction signature of podocytes in health and disease
    (Project Heads Köhler, Sybille ; Mühlig, Anne Katrin )
Graduate Schools
- Completed projects
  - GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED)
    (Spokesperson Borner, Christoph )

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