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Institution
Universitätsklinikum Bonn
Institut für Experimentelle Epileptologie und Kognitionsforschung
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Heisenberg Fellowships
Completed projects
Physiologie
(Applicant
Beck, Heinz
)
Research Grants
Current projects
A polyamine-dependent mechanism underlying pharmacoresistance to anticonvulsant drugs in chronic epilepsy
(Applicant
Beck, Heinz
)
Astrocytic transformation as a driver of encephalitis-triggered epilepsy
(Applicants
Henneberger, Christian
;
Schoch McGovern, Susanne
;
Wenzel, Michael
)
Cellular scale neuroimmune network mechanisms underlying antibody-driven autoimmune encephalitis
(Applicants
Pitsch, Julika
;
Wenzel, Michael
)
Dendritic Shaft Constrictions: A Newly Identified Nanoscale Feature Shaping Synaptic Integration
(Applicants
Beck, Heinz
;
Nägerl, Ph.D., Urs Valentin
)
EphrinB2 modulation of neuronal morphology and ensemble activity to encode long-term memory: an integrated theory-experiment approach
(Applicants
Gründemann, Ph.D., Jan
;
Tchumatchenko, Tatjana
)
Neuro-aCSis – Bonn Neuroscience Clinician Scientist Program
(Applicant
Petzold, Gabor
)
Olfactory and spatial coding along the proximodistal axis of hippocampal region CA1 during goal-oriented navigation
(Applicants
Ackels, Tobias
;
Barnstedt, Oliver
)
Targeting the polyamine metabolism to treat pharmacoresistant epilepsy
(Applicants
Beck, Heinz
;
Van Loo, Karen
)
The role of spreading depression in the development of chronic epilepsy
(Applicant
Wenzel, Michael
)
Completed projects
Function of Gamma-Protocadherins during postnatal neurogenesis in mice
(Applicant
Schwarz, Ph.D., Karl Martin
)
Network function of early born glutamatergic neurons in health and disease
(Applicant
Beck, Heinz
)
Reversing CRF-induced inhibition of KCa3.1 channels to treat acquired epilepsy
(Applicant
Beck, Heinz
)
Priority Programmes
Current projects
Cortico-thalamic feedback loops for representational stabilization of visual sensation
(Applicants
Rose, Tobias
;
Tchumatchenko, Tatjana
)
Completed projects
Combining theory and experiments to infer how recurrent and top-down connectivity in the corticothalamic circuit gives rise to V1 selectivity
(Applicants
Busse, Laura
;
Tchumatchenko, Tatjana
)
High resolution connectivity analysis of CA3/ DG engrams: from behavior to structure
(Applicants
Beck, Heinz
;
Kubitscheck, Ulrich
;
Schwarz, Ph.D., Karl Martin
)
Regional and trans-regional heterogeneity of astrocyte morphology as a functional determinant of synaptic astrocyte-neuron interactions in the hippocampus
(Applicants
Henneberger, Christian
;
Schwarz, Ph.D., Karl Martin
)
Clinical Research Units
Completed projects
Mechanisms of microglia-mediated neuronal damage and dysfunction: Role of the "TNFa-Zn2+" cascade
(Applicant
Beck, Heinz
)
Major Research Instrumentation
Completed projects
Confocal Microscope
Focused ion beam scanning electron microscope (FIB-SEM)
High content screening microscope
Konfokalmikroskop
Multiphotonen-Mikroskop mit in-vitro-Setup
Multiphotonen-Mikroskop mit in-vivo-Setup
Point-scanning confocal with area detector
Slide scanner microscope
Spinning disk confocal microscope
Wide-field microscope (Renewal)
Collaborative Research Centres
Current projects
Energy optimization as an organizing principle for protein dynamics at the synapse
(Project Head
Tchumatchenko, Tatjana
)
SFB 1286: Quantitative Synaptology
(Spokesperson
Rizzoli, Ph.D., Silvio-Olivier
)
Completed projects
Advanced Neuronal Circuit Labeling and Behavioral Analysis
(Project Head
Schwarz, Ph.D., Karl Martin
)
Allocation, consolidation, and gating of spatial memory in retrosplenial cortex
(Project Head
Rose, Tobias
)
An inverse approach to the identification and manipulation of neuronal circuits underlying olfactory-mediated habituation/discrimination
(Project Heads
Fuhrmann, Martin
;
Schwarz, Ph.D., Karl Martin
)
Central Tasks
(Project Head
Beck, Heinz
)
Circuit mechanisms of altered excitability in experimental cortical malformations
(Project Heads
Beck, Heinz
;
Schoch McGovern, Susanne
)
Control of spatial coding by NMDAR co-agonists and astrocytic signaling
(Project Heads
Beck, Heinz
;
Dietrich, Dirk
;
Henneberger, Christian
)
Homeostatic regulation of protein copy numbers and its impact on neural network activity
(Project Head
Tchumatchenko, Tatjana
)
Information Infrastructure - Establishment of CRC-wide computational toolbox and collaborative writing and code repositories
(Project Heads
Rose, Tobias
;
Tchumatchenko, Tatjana
)
Integrated Research Training Group
(Project Heads
Beck, Heinz
;
Schoch McGovern, Susanne
)
Microcircuit mechanisms underlying epileptogenesis and behavioural impairment in anti-Drebrin auto-antibody mediated limbic encephalitis
(Project Heads
Becker, Albert
;
Wenzel, Michael
)
Network alterations between hippocampus, entorhinal and prefrontal cortex contributing to spatial working memory impairment under AD-like conditions
(Project Heads
Fuhrmann, Martin
;
Poll, Stefanie
;
Remy, Stefan
)
Recombinant adeno-associated- and lentiviral technologies
(Project Heads
Becker, Albert
;
Grömping, Yvonne
;
van Loo, Karen M. J.
;
Schoch McGovern, Susanne
;
Schwarz, Ph.D., Karl Martin
)
SFB 1089: Synaptic Micronetworks in Health and Disease
(Spokesperson
Beck, Heinz
)
Structural synaptic changes and their role in experience-dependent plasticity
(Project Heads
Bonhoeffer, Tobias
;
Rose, Tobias
;
Scheuss, Volker
)
Thalamocortical control of context invariant cortical output
(Project Heads
Oberlaender, Marcel
;
Tchumatchenko, Tatjana
)
The role of the hippocampal CA3 network in integration of spatial and non-spatial information
(Project Heads
Beck, Heinz
;
Tchumatchenko, Tatjana
)
Research Fellowships
Completed projects
Mechanisms of processing temporally structured olfactory stimuli
(Applicant
Ackels, Tobias
)
Optical containment of epilepsy using Two-Photon-Light
(Applicant
Wenzel, Michael
)
Research Units
Current projects
FOR 2715: Epileptogenesis of genetic epilepsies
(Spokesperson
Lerche, Holger
)
Hippocampal integration during epileptogenesis of genetic epilepsies: Developmental intervention
(Applicants
Beck, Heinz
;
Kelly, Ph.D., Tony
)
Optimization and distribution of a precise odour delivery device
(Applicants
Ackels, Tobias
;
Rothermel, Markus
)
CRC/Transregios
Completed projects
Metaplastizität synaptischer Übertragung: Interaktion mit Gedächtnisprozessen bei humaner Epilepsie und Epilepsietiermodellen
(Project Heads
Beck, Heinz
;
Elger, Christian E.
;
Manahan-Vaughan, Denise
)
Molecular mechanisms of pharmacoresistance in epilepsy patients
(Project Heads
Beck, Heinz
;
Elger, Christian E.
;
Heinemann, Uwe
)
Role of subthreshold Na+ conductances in epileptogenesis
(Project Heads
Beck, Heinz
;
Yaari, Yoel
)
Research Training Groups
Current projects
GRK 3151: Development and epileptogenesis of dysplasias in the interplay of distinct CNS cell types
(Spokesperson
Becker, Albert
)
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