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Universität zu Köln
CECAD - Forschungszentrum
Exzellenzcluster CECAD

Address Joseph-Stelzmann-Straße 26
50931 Köln
Deutschland

GERiT This institution in GERiT

50931 Köln

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
  - Untersuchungen zur Rolle von I-kappa-B Kinase (IKK) Untereinheiten in der Entstehung des Hepatozellulären Karzinoms, Verwendung von konditionellen Knockoutmäusen zur spezifischen Gendeletion von Ikk1, Ikk2 und Nemo in der Leber
    (Applicant Lüdde, Ph.D., Tom )
Collaborative Research Centres
- Current projects
  - Bioanalytical Platform
    (Project Heads Brodesser, Susanne ; Frezza, Christian ; Krüger, Marcus ; Trifunovic, Aleksandra )
  - Cardiolipin-dependent regulation of T cell immunity
    (Project Head Corrado, Mauro )
  - Cellular quality control by mitofusins and ubiquitin
    (Project Head Escobar-Henriques, Mafalda )
  - Central Tasks
    (Project Head Pasparakis, Manolis )
  - Central Tasks of the Collaborative Research Centre
    (Project Head Rugarli, Elena Irene )
  - Characterization of metabolic repro-gramming in Small Cell Lung Cancer subtype plasticity and progression
    (Project Head Frezza, Christian )
  - Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach
    (Project Heads Garcia Sáez, Ana Jesús ; Pasparakis, Manolis )
  - Genetically engineered mouse models for the study of cell death and its role in immunity and inflammation
    (Project Head Pasparakis, Manolis )
  - Immunological dissection of cell death-induced inflammation in human disease
    (Project Head Oda, Ph.D., Hirotsugu )
  - Inflammatory and necroptotic signaling in SCLC
    (Project Head Pasparakis, Manolis )
  - Mechanisms of cell death-induced inflammation
    (Project Head Pasparakis, Manolis )
  - Mitochondrial structure and dynamics in light and electron microscopy
    (Project Heads Garcia Sáez, Ana Jesús ; Schauss, Astrid )
  - Motor learning-induced plasticity of cerebellar Purkinje neuron connectivity
    (Project Head Bergami, Ph.D., Matteo )
  - Quantitative Proteomics
    (Project Head Krüger, Marcus )
  - Role of mitochondrial dynamics in neuronal synapse and circuit remodelling
    (Project Head Bergami, Ph.D., Matteo )
  - SFB 1218: Mitochondrial regulation of cellular function
    (Spokespersons Langer, Thomas ; Rugarli, Elena Irene )
  - SFB 1403: Cell Death in Immunity, Inflammation and Disease
    (Spokesperson Pasparakis, Manolis )
  - The link between mitochondrial ultrastructure and innate immune response upon fumarate hydratase loss
    (Project Heads Frezza, Christian ; Schatton, Dèsirée )
  - The role of CLUH in the translation of mRNAs encoding mitochondrial proteins
    (Project Head Rugarli, Elena Irene )
  - Thrombospondin-1 and NF-κB signaling in ocular graft-versus-host disease (GVHD)
    (Project Heads Pasparakis, Manolis ; Steven, Philipp )
- Completed projects
  - Central animal facility: Generation, breeding and husbandry of mice including murine infection models
    (Project Heads Kastenmüller, Wolfgang ; Knolle, Percy Alexander ; Mahabir-Brenner, Esther ; Pasparakis, Manolis ; Utermöhlen, Olaf )
  - Characterization of an ancient cell death signaling module
    (Project Heads Hofmann, Kay ; Pasparakis, Manolis )
  - Epithelial TNFR1 signalling in skin homeostasis and inflammation
    (Project Head Pasparakis, Manolis )
  - Imaging-unit
    (Project Heads Büning, Hildegard ; Kashkar, Hamid ; Latz, Eicke ; Protzer, Ulrike ; Schauss, Astrid ; Utermöhlen, Olaf )
  - Innate receptor signalling in host defence
    (Project Head Pasparakis, Manolis )
  - In vivo-Proteomik des IKK-Komplexes
    (Project Head Pasparakis, Manolis )
  - Role of mitochondria in the regulation of intestinal epithelial cell death and inflammation
    (Project Head Pasparakis, Manolis )
  - Zentrale Proteinanalyse
    (Project Heads Hanisch, Franz-Georg ; Lamkemeyer, Tobias )
Major Research Instrumentation
- Completed projects
Research Units
- Current projects
  - FACIT collagens XII and XIV and their role in musculoskeletal homeostasis and regeneration
    (Applicants Koch, Manuel ; Krüger, Marcus )
  - FOR 2722: Novel molecular determinants for musculoskeletal extracellular matrix homeostasis – a systemic approach (M2)
    (Spokesperson Brachvogel, Bent )
Priority Programmes
- Current projects
  - MFN2 role, origin and evolution in protein aggregation and mitochondrial import capacity
    (Applicants Escobar-Henriques, Mafalda ; Hofmann, Kay )
- Completed projects
  - TLR-mediated microbiota-host interaction in the regulation of intestinal homeostasis and nflammation
    (Applicant Pasparakis, Manolis )
Research data and software
- Completed projects
  - Systembiologische Analysen des Krebsgenoms mit Hilfe deduktiver Datenbanken
    (Applicants Frommolt, Peter ; Lang, Ulrich ; Larsson, Nils-Göran )
Clinical Research Units
- Current projects
  - Central mouse generation, phenotyping and imaging
    (Applicants Bozek, Katarzyna ; Schauss, Astrid )
  - KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
    (Spokesperson Benzing, Thomas )
CRC/Transregios
- Current projects
  - Necroptosis in aortic aneurysm disease - significance of inflammation in MLKL dependent cell death
    (Project Heads Adam, Matti ; Garcia Sáez, Ana Jesús ; Pasparakis, Manolis )
Core Facilities
- Completed projects
  - Improvement of the central microscopy research infrastructure Center for Advanced Imaging (CAi) at Heinrich Heine University Düsseldorf
    (Applicant Weidtkamp-Peters, Stefanie )
Research Training Groups
- Current projects
  - GRK 2550: Dynamic regulation of cellular protein localization
    (Spokesperson Riemer, Jan )
- Completed projects
  - GRK 1960: Neural Circuit Analysis on the Cellular and Subcellular Level
    (Spokesperson Büschges, Ansgar )
  - GRK 2407: Inflammatory and cellular stress signaling: Switches to vascular dysfunction
    (Spokesperson Baldus, Stephan )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2030: CECAD - Excellent in Aging Research
    (Spokespersons Benzing, Thomas ; Hoppe, Thorsten ; Niessen, Carien )
Clusters of Excellence
- Completed projects
  - EXC 147: Cardio-Pulmonary System
    (Spokespersons Dimmeler, Stefanie ; Seeger, Werner ; Zeiher, Andreas Michael )
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases
    (Spokesperson Brüning, Jens Claus )

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