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Institution

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Universität des Saarlandes
CIPMM - Center for Integrative Physiology and Molecular Medicine

Address Kirrberger Straße
66424 Homburg
Deutschland

GERiT This institution in GERiT

66424 Homburg

Projects

Research Grants
- Current projects
  - Role of adenosine signaling in oligodendrocyte regeneration and remyelination
    (Applicant Huang, Wenhui )
- Completed projects
Priority Programmes
- Current projects
  - SPP 1757: Functional Specialisations of Neuroglia as Critical Determinants of Brain Activity
    (Spokesperson Kirchhoff, Frank )
- Completed projects
  - A dual STIM2 redox switch in melanoma immunology
    (Applicants Bogeski, Ivan ; Hoth, Markus )
  - Analysis of single signalling molecules at the synaptic astroglia-neuron interface
    (Applicant Kirchhoff, Frank )
  - Coordination Funds
    (Applicants Kirchhoff, Frank ; Rose, Christine R. )
  - Coordinator Project - Coordination, promotion, workshops, summer schools
    (Applicant Friauf, Eckhard )
  - Function of family-C V2R genes: an integrated analysis of DeltaV2R-C mice
    (Applicants Mombaerts, Peter ; Zufall, Frank )
  - Gliotransmitter release in astrocytic heterogeneity and brain activity
    (Applicants Bruns, Dieter ; Schwarz, Ph.D., Yvonne )
  - Heterogeneity of transmitter receptor-linked Ca2+ signals in astrocytes II
    (Applicant Kirchhoff, Frank )
  - Molekulare Sinnesphysiologie: Isolierung von Geschmacksrezeptor cDNAs
    (Applicant Meyerhof, Wolfgang )
  - Neuronal mechanisms of pheromone sensing
    (Applicants Boehm, Ulrich ; Leinders-Zufall, Trese )
  - Role of voltage-gated calcium channel alpha2delta subunits for spiral ganglion neurons and afferent auditory processing
    (Applicant Engel, Jutta )
  - SPP 1608: Ultrafast and Temporally Precise Information Processing: Normal and Dysfunctional Hearing
    (Spokespersons Engel, Jutta ; Friauf, Eckhard )
Research Units
- Completed projects
  - FOR 2289: Calcium homeostasis in neuroinflammation and -degeneration: New targets for therapy of multiple sclerosis?
    (Spokesperson Diem, Ricarda )
  - Role of glial Ca2+ signals during neuroinflammation, axonal degeneration, and de- and remyelination in the mouse spinal cord – Part II
    (Applicants Kirchhoff, Frank ; Scheller, Anja )
Collaborative Research Centres
- Current projects
  - Dynamics of polarization of T cells and NK cells
    (Project Heads Hoth, Markus ; Qu, Bin )
  - Glial adrenergic receptors as targets for the treatment of neuropathic pain
    (Project Heads Agarwal, Ph.D., Amit ; Kirchhoff, Frank ; Kuner, Rohini ; Simonetti, Ph.D., Manuela )
  - Killing efficiency of cytotoxic T lymphocytes and natural killer cells against cancer cells
    (Project Head Hoth, Markus )
  - The role of protein-lipid interactions in fast Ca2+-triggered exocytosis
    (Project Heads Bruns, Dieter ; Mohrmann, Ralf ; Schwarz, Ph.D., Yvonne )
- Completed projects
  - Ca2+ channel complexes in the cochlea synaptopathy
    (Project Head Engel, Jutta )
  - Ca2+-dependent CTL and NK cell cytotoxicity
    (Project Head Hoth, Markus )
  - CAPS function in dorsal root ganglion neurons
    (Project Head Becherer, Ph.D., Ute )
  - Complexin and synaptotagmin in Ca2+-triggered exocytosis
    (Project Head Bruns, Dieter )
  - Cytotoxic T lymphocyte function in vitro and in vivo
    (Project Heads Pattu, Varsha ; Rettig, Jens )
  - Function and regulation of Ca2+ signals in identified hypothalamic neurons
    (Project Head Leinders-Zufall, Trese )
  - Light nanoscopy
    (Project Heads Krause, Elmar ; Rettig, Jens )
  - Mechanisms of receptor-operated Ca2+ signals in pheromone-detecting sensory neurons
    (Project Heads Leinders-Zufall, Trese ; Zufall, Frank )
  - Molecular mechanisms of exocytosis
    (Project Head Bruns, Dieter )
  - Molecular Mechanisms of Pheromone Detection
    (Project Head Zufall, Frank )
  - Neurotransmitter receptors and Ca2+ signals in cerebellar Bergmann glia
    (Project Heads Kirchhoff, Frank ; Lauterbach, Marcel )
  - Regulation von Ca2+ Einstromwegen in elektrisch nicht-erregbaren Zelltypen
    (Project Heads Krause, Elmar ; Schulz-Hofer, Irene )
  - Role of second messengers in the regulation of chromaffin cells secretion
    (Project Head Becherer, Ph.D., Ute )
  - Spontaneous activity in the developing cochlea
    (Project Head Engel, Jutta )
  - Subcellular analysis of T-cell activation
    (Project Head Hoth, Markus )
Emmy Noether International Fellowships
- Completed projects
  - Charakterisierung molekularer Mechanismen der Pheromon-vermittelten Signaltransduktion bei Nagetieren (Mausmodell)
    (Applicant Spehr, Marc )
Major Research Instrumentation
- Completed projects
CRC/Transregios
- Current projects
  - Novel TRP channel functions in olfaction
    (Project Heads Leinders-Zufall, Trese ; Zufall, Frank )
  - TRPC channels in synaptic short-term plasticity and secretion
    (Project Heads Bruns, Dieter ; Schwarz, Ph.D., Yvonne )
- Completed projects
  - Analysis of immediate cellular response cascades upon defined CNS lesions by in vivo two-photon laser-scanning microscopy
    (Project Head Kirchhoff, Frank )
  - Functional role of TRP channels in neuroendocrine cells of the brain
    (Project Head Leinders-Zufall, Trese )
Research Fellowships
- Completed projects
  - Thalamic control of motor cortex activity during skilled motor behaviour
    (Applicant Schiemann, Julia )
CRC/Transfer Units
- Completed projects
  - Internalisierung von heptahelikalen Rezeptoren und deren Liganden - Anwendung in der bildgebenden Diagnostik
    (Project Heads Meinhold, Harald ; Meyerhof, Wolfgang ; Wiedenmann, Bertram )
Major Instrumentation Initiatives
- Completed projects
  - Real-time Nanoscopy
Research Training Groups
- Completed projects
  - GRK 377: Cellular Regulation and Growth
    (Spokesperson Montenarh, Mathias )
  - GRK 845: Molecular, Physiological and Pharmacological Analysis of Cellular Membrane Transport
    (Spokespersons Neuhaus, Ekkehard ; Zimmermann, Richard )
  - GRK 1326: Calcium-Signalling and Cellular Nanodomains
    (Spokesperson Bruns, Dieter )
International Research Training Groups
- Completed projects
  - GRK 1830: Complex Membrane Proteins in Cellular Development and Disease
    (Spokespersons Neuhaus, Ekkehard ; Niemeyer, Ph.D., Barbara Anne )

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