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Institution
Charité - Universitätsmedizin Berlin
Campus Charité Mitte
Klinik für Dermatologie, Venerologie und Allergologie
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Units
Current projects
FOR 2690: Translational Pruritus Research
(Spokesperson
Schmelz, Martin
)
Completed projects
Electrical stimulation models and mediators conveying pruritus in allergic contact dermatitis and urticaria patients
(Applicants
Metz, Martin
;
Rukwied, Roman
;
Weisshaar, Elke
)
FOR 2497: Pemphigus - from Pathogenesis to Therapeutics (Pegasus)
(Spokesperson
Hertl, Michael
)
Quantification of antigen-dependent cell biological responses of T-lymphocytes
(Applicant
Walden, Ph.D., Peter
)
T-cell-dependent regulation of autoreactive B cells in pemphigus
(Applicants
Ghoreschi, Kamran
;
Möbs, Christian
)
Research Fellowships
Completed projects
Blockade der Hedgehog-Signaltransduktion durch intradermale Vakzination von ptch+/-knock out-Mäusen mit Hip-RNA
(Applicant
Vogt, Annika
)
Die Rolle von Endothelin-1 im Rahmen allergischer Reaktionen
(Applicant
Metz, Martin
)
Klonierung, Expression und Charakterisierung der Sphingosin-1-Phosphatase in Säugetierzellen
(Applicant
Bektas, Meryem
)
Research Grants
Current projects
IgE-independent Stimulation of Mast Cells in Cholinergic Urticaria
(Applicant
Metz, Martin
)
Completed projects
Adaption of nanocarrier-based drug delivery systems to the redox-state and thiol gradients of healthy and diseased skin
(Applicants
Haag, Rainer
;
Rühl, Eckart
;
Vogt, Annika
)
Analysis of the presentation of tumour associated antigens by tumour and antigen presenting cells with newly developed recombinant single chain antibodies with T cell receptor-like specificity
(Applicant
Walden, Ph.D., Peter
)
Benefit of placebo effects in atopic dermatitis - Increase of the pharmacological effects in itching via processes of conditioning and expectation
(Applicants
Klinger, Regine
;
Worm, Margitta
)
CD30+ Zellen in lymphoproliferativen Erkrankungen der Haut - Histologische und molekulargenetische Untersuchungen mit Hilfe der Mikromanipulation und Einzel-Zell-PCR
(Applicant
Gellrich, Sylke
)
Cellular and molecular mechanisms of TNF (tumor necrosis factor-alpha) mediated protection in atopic dermatitis
(Applicant
Worm, Margitta
)
Characterization of the Prevalence, Immunologic Features, and Clinical Implications of Autoimmune Subtypes of Chronic Spontaneous Urticaria (CAS-CSU)
(Applicant
Metz, Martin
)
Cyclooxygenasen as modulators of allergic responses, mechanistic background and therapeutic potential
(Applicant
Worm, Margitta
)
Epigenetic alterations of TA-keratinocytes as underlying cause of hyperproliferation in psoriasis
(Applicant
Witte, Katrin
)
Humane Mastzellen im neurohormonalen Netzwerk - Funktionelle Bedeutung der POMC-Peptide bei menschlichen Mastzellen
(Applicant
Henz, Beate
)
Identification and characterization of the mechanisms and relevance of inflammasome activation in mast cells
(Applicant
Maurer, Marcus
)
Identifizierung und Charakterisierung der Relevanz und der Mechanismen einer Mastzell-vermittelten Deaktivierung von Toxinen
(Applicant
Metz, Martin
)
Isolierung von Punktmutationen und Polymorphismen bei malignen Tumoren der Haut: Genetische Mikro-Unterschiede als alleiniges Selektionskriterium
(Applicant
Hansen-Hagge, Thomas E.
)
Mechanisms of mast cells and T cells interaction during viral infections
(Applicant
Munoz Roldan, Ph.D., Melba
)
Modulation of interferon sensitivity in psoriasis by NF kappaB
(Applicant
Foerster, John P.
)
Off-label prescriptions in dermatology: A prospective, multicentre and supraregional study of applications and decisions on the reimbursement of costs in Germany
(Applicant
Werner, Ricardo Niklas
)
Rolle von Interleukin(IL)-22 in der pulmonalen Abwehr gegen Cryptococcus neoformans
(Applicants
Alber, Gottfried
;
Sabat, Robert
)
sFcεRI as a potential biomarker for Endotypes of Chronic Urticaria (SECU)
(Applicant
Moñino-Romero, Ph.D., Sherezade
)
Untersuchung der Prozessierung von MHC-Klasse-I-restringierten Antigenen durch Selektion und Analyse von mutanten Melanomzellen mit defekter Antigenpräsentation
(Applicant
Kloetzel, Peter Michael
)
Untersuchung und Identifikation von geeigneten Begriffen zur Formulierung von Empfehlungen in medizinischen Leitlinien
(Applicant
Nast, Alexander
)
Vergleichende Untersuchungen zur Regulation und Funktion von ICAM-3 (CD50) und Leukosialin (CD43) bei verschiedenen myeloischen Zellen
(Applicant
Henz, Beate
)
Weitere Charakterisierung des Einflusses von IL-28 und IL-29 auf die Haut und das Immunsystem: Zielzellen, Regulation der zellulären Empfindlichkeit, Effekte
(Applicant
Wolk, Ph.D., Kerstin
)
Clinical Research Units
Current projects
Cellular stratification of atopic inflammatory circuits
(Applicant
Thiel, Andreas
)
Coordination Funds
(Applicant
Worm, Margitta
)
Food allergy versus tolerance – direction by antigen specific immunologic reactivity
(Applicant
Worm, Margitta
)
KFO 339: Food Allergy and Tolerance (Food@)
(Spokesperson
Worm, Margitta
)
Serological biomarkers to detect food allergy
(Applicants
Babina, Magda
;
Dölle-Bierke, Sabine
)
Tolerance induction through non-avoidance to prevent persistent food allergy
(Applicant
Beyer, Kirsten
)
Completed projects
Identification and characterization of the IgEome and its role and relevance in food allergy
(Applicant
Altrichter, Sabine
)
Priority Programmes
Completed projects
A therapeutic approach to enhance innate defense mechanisms against toxins and venoms - mast cell proteases to the rescue
(Applicant
Metz, Martin
)
A whole body Radiomics approach in patients with metastatic melanoma undergoing systemic therapy: Fully automated longitudinal segmentation and Deep Learning-based outcome prediction
(Applicants
Eigentler, Thomas
;
Gerken, Annika
;
Othman, Ahmed
;
Peisen, Felix
)
Einfluß von Adhäsionsrezeptoren auf die phänotypische und funktionelle Differenzierung von Mastzellen in epithelialen Geweben
(Applicant
Henz, Beate
)
Nanopartikels Containing Selective Probes: Interaction Mechanisms of Nanoparticles with Cell Membranes, Intracellular Uptake, and Transport (NANO-SELECT)
(Applicants
Gruber, Ph.D., Achim Dieter
;
Jordan, Andreas
;
Lademann, Jürgen
;
Rühl, Eckart
)
Collaborative Research Centres
Completed projects
EPR spectroscopic investigations on drug delivery and release of nanocarriers into excised skin and 3D-skin models
(Project Heads
Bittl, Robert
;
Meinke, Martina
)
Immune modulation of allergic diseases by nuclear hormone receptor ligands
(Project Heads
Heine, Guido
;
Radbruch, Andreas
;
Worm, Margitta
)
Impact of inflammatory microenvironment on nanocarrier penetration, drug release, and biological effects in human skin
(Project Heads
Blume-Peytavi, Ulrike
;
Vogt, Annika
)
Mast cell-driven down regulation of chronic inflammation
(Project Heads
Maurer, Marcus
;
Metz, Martin
)
The cross-regulation of IL-4, IL-33 and IL1ß signaling balances Th2]mediated disease
(Project Heads
Ghoreschi, Kamran
;
Yazdi, Amir Sadegh
)
Triggered release of drugs from nanocarriers within the hair follicles
(Project Head
Lademann, Jürgen
)
Major Research Instrumentation
Completed projects
6-Laser Multiparameter Flow Cytometer
CRC/Transregios
Completed projects
Effects of antipsoriatic therapies on aberrant IL-6/STAT3 signaling in psoriasis
(Project Heads
Eberle, Franziska
;
Ghoreschi, Kamran
)
Regulation of B cell differentiation by vitamin A and D
(Project Heads
Heine, Guido
;
Worm, Margitta
)
Regulation of Th17-mediated skin inflammation by heme oxygenase 1 and inflammasome activation
(Project Heads
Ghoreschi, Kamran
;
Yazdi, Amir Sadegh
)
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