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Institution
Charité - Universitätsmedizin Berlin
Campus Charité Mitte
Klinik für Dermatologie, Venerologie und Allergologie
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Units
Current projects
Electrical stimulation models and mediators conveying pruritus in allergic contact dermatitis and urticaria patients
(Applicants
Metz, Martin
;
Rukwied, Roman
;
Weisshaar, Elke
)
FOR 2497: Pemphigus - from Pathogenesis to Therapeutics (Pegasus)
(Spokesperson
Hertl, Michael
)
FOR 2690: Translational Pruritus Research
(Spokesperson
Schmelz, Martin
)
Completed projects
Quantification of antigen-dependent cell biological responses of T-lymphocytes
(Applicant
Walden, Ph.D., Peter
)
T-cell-dependent regulation of autoreactive B cells in pemphigus
(Applicants
Ghoreschi, Kamran
;
Möbs, Christian
)
Research Fellowships
Completed projects
Blockade der Hedgehog-Signaltransduktion durch intradermale Vakzination von ptch+/-knock out-Mäusen mit Hip-RNA
(Applicant
Vogt, Annika
)
Die Rolle von Endothelin-1 im Rahmen allergischer Reaktionen
(Applicant
Metz, Martin
)
Klonierung, Expression und Charakterisierung der Sphingosin-1-Phosphatase in Säugetierzellen
(Applicant
Bektas, Meryem
)
Research Grants
Current projects
Characterization of the Prevalence, Immunologic Features, and Clinical Implications of Autoimmune Subtypes of Chronic Spontaneous Urticaria (CAS-CSU)
(Applicant
Metz, Martin
)
IgE-independent Stimulation of Mast Cells in Cholinergic Urticaria
(Applicant
Metz, Martin
)
Completed projects
Adaption of nanocarrier-based drug delivery systems to the redox-state and thiol gradients of healthy and diseased skin
(Applicants
Haag, Rainer
;
Rühl, Eckart
;
Vogt, Annika
)
Analysis of the presentation of tumour associated antigens by tumour and antigen presenting cells with newly developed recombinant single chain antibodies with T cell receptor-like specificity
(Applicant
Walden, Ph.D., Peter
)
Benefit of placebo effects in atopic dermatitis - Increase of the pharmacological effects in itching via processes of conditioning and expectation
(Applicants
Klinger, Regine
;
Worm, Margitta
)
CD30+ Zellen in lymphoproliferativen Erkrankungen der Haut - Histologische und molekulargenetische Untersuchungen mit Hilfe der Mikromanipulation und Einzel-Zell-PCR
(Applicant
Gellrich, Sylke
)
Cellular and molecular mechanisms of TNF (tumor necrosis factor-alpha) mediated protection in atopic dermatitis
(Applicant
Worm, Margitta
)
Cyclooxygenasen as modulators of allergic responses, mechanistic background and therapeutic potential
(Applicant
Worm, Margitta
)
Epigenetic alterations of TA-keratinocytes as underlying cause of hyperproliferation in psoriasis
(Applicant
Witte, Katrin
)
Humane Mastzellen im neurohormonalen Netzwerk - Funktionelle Bedeutung der POMC-Peptide bei menschlichen Mastzellen
(Applicant
Henz, Beate
)
Identification and characterization of the mechanisms and relevance of inflammasome activation in mast cells
(Applicant
Maurer, Marcus
)
Identifizierung und Charakterisierung der Relevanz und der Mechanismen einer Mastzell-vermittelten Deaktivierung von Toxinen
(Applicant
Metz, Martin
)
Isolierung von Punktmutationen und Polymorphismen bei malignen Tumoren der Haut: Genetische Mikro-Unterschiede als alleiniges Selektionskriterium
(Applicant
Hansen-Hagge, Thomas E.
)
Mechanisms of mast cells and T cells interaction during viral infections
(Applicant
Munoz Roldan, Ph.D., Melba
)
Modulation of interferon sensitivity in psoriasis by NF kappaB
(Applicant
Foerster, John P.
)
Off-label prescriptions in dermatology: A prospective, multicentre and supraregional study of applications and decisions on the reimbursement of costs in Germany
(Applicant
Werner, Ricardo Niklas
)
Rolle von Interleukin(IL)-22 in der pulmonalen Abwehr gegen Cryptococcus neoformans
(Applicants
Alber, Gottfried
;
Sabat, Robert
)
sFcεRI as a potential biomarker for Endotypes of Chronic Urticaria (SECU)
(Applicant
Moñino-Romero, Ph.D., Sherezade
)
Untersuchung der Prozessierung von MHC-Klasse-I-restringierten Antigenen durch Selektion und Analyse von mutanten Melanomzellen mit defekter Antigenpräsentation
(Applicant
Kloetzel, Peter Michael
)
Untersuchung und Identifikation von geeigneten Begriffen zur Formulierung von Empfehlungen in medizinischen Leitlinien
(Applicant
Nast, Alexander
)
Vergleichende Untersuchungen zur Regulation und Funktion von ICAM-3 (CD50) und Leukosialin (CD43) bei verschiedenen myeloischen Zellen
(Applicant
Henz, Beate
)
Weitere Charakterisierung des Einflusses von IL-28 und IL-29 auf die Haut und das Immunsystem: Zielzellen, Regulation der zellulären Empfindlichkeit, Effekte
(Applicant
Wolk, Ph.D., Kerstin
)
Clinical Research Units
Current projects
Cellular stratification of atopic inflammatory circuits
(Applicant
Thiel, Andreas
)
Coordination Funds
(Applicant
Worm, Margitta
)
Food allergy versus tolerance – direction by antigen specific immunologic reactivity
(Applicant
Worm, Margitta
)
KFO 339: Food Allergy and Tolerance (Food@)
(Spokesperson
Worm, Margitta
)
Serological biomarkers to detect food allergy
(Applicants
Babina, Magda
;
Dölle-Bierke, Sabine
)
Tolerance induction through non-avoidance to prevent persistent food allergy
(Applicant
Beyer, Kirsten
)
Completed projects
Identification and characterization of the IgEome and its role and relevance in food allergy
(Applicant
Altrichter, Sabine
)
Priority Programmes
Completed projects
A therapeutic approach to enhance innate defense mechanisms against toxins and venoms - mast cell proteases to the rescue
(Applicant
Metz, Martin
)
A whole body Radiomics approach in patients with metastatic melanoma undergoing systemic therapy: Fully automated longitudinal segmentation and Deep Learning-based outcome prediction
(Applicants
Eigentler, Thomas
;
Gerken, Annika
;
Othman, Ahmed
;
Peisen, Felix
)
Einfluß von Adhäsionsrezeptoren auf die phänotypische und funktionelle Differenzierung von Mastzellen in epithelialen Geweben
(Applicant
Henz, Beate
)
Nanopartikels Containing Selective Probes: Interaction Mechanisms of Nanoparticles with Cell Membranes, Intracellular Uptake, and Transport (NANO-SELECT)
(Applicants
Gruber, Ph.D., Achim Dieter
;
Jordan, Andreas
;
Lademann, Jürgen
;
Rühl, Eckart
)
Collaborative Research Centres
Completed projects
EPR spectroscopic investigations on drug delivery and release of nanocarriers into excised skin and 3D-skin models
(Project Heads
Bittl, Robert
;
Meinke, Martina
)
Immune modulation of allergic diseases by nuclear hormone receptor ligands
(Project Heads
Heine, Guido
;
Radbruch, Andreas
;
Worm, Margitta
)
Impact of inflammatory microenvironment on nanocarrier penetration, drug release, and biological effects in human skin
(Project Heads
Blume-Peytavi, Ulrike
;
Vogt, Annika
)
Mast cell-driven down regulation of chronic inflammation
(Project Heads
Maurer, Marcus
;
Metz, Martin
)
The cross-regulation of IL-4, IL-33 and IL1ß signaling balances Th2]mediated disease
(Project Heads
Ghoreschi, Kamran
;
Yazdi, Amir Sadegh
)
Triggered release of drugs from nanocarriers within the hair follicles
(Project Head
Lademann, Jürgen
)
Major Research Instrumentation
Completed projects
6-Laser Multiparameter Flow Cytometer
CRC/Transregios
Completed projects
Effects of antipsoriatic therapies on aberrant IL-6/STAT3 signaling in psoriasis
(Project Heads
Eberle, Franziska
;
Ghoreschi, Kamran
)
Regulation of B cell differentiation by vitamin A and D
(Project Heads
Heine, Guido
;
Worm, Margitta
)
Regulation of Th17-mediated skin inflammation by heme oxygenase 1 and inflammasome activation
(Project Heads
Ghoreschi, Kamran
;
Yazdi, Amir Sadegh
)
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