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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Institut für Molekulare Medizin
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Grants
Current projects
ADAM-mediated fine-tuning of antigen-presenting cell homeostasis and function in the intestine
(Applicant
Clausen, Björn
)
Charcot Marie Tooth disease 4A - GDAP1-mediated redox-dependent interaction of mitochondria with the cytoskeleton
(Applicant
Methner, Axel
)
Dysbiosis development in mice with deficient IL-17 signaling in keratinocytes
(Applicants
Kurschus, Ph.D., Florian
;
Regen, Tommy
)
E-cadherin and β-catenin signaling in Langerhans cells and DC for the maintenance of immune homeostasis in the oral mucosa
(Applicant
Clausen, Björn
)
Uncovering the roles of proinflammatory cytokine signaling in NG2-glia cells during neuroinflammation and demyelination
(Applicant
Papic, Ph.D., Maja
)
Completed projects
ADAMs going viral: novel regulators of dendritic cell function during viral infection
(Applicant
Backer, Ph.D., Ronald
)
Cell-type specific IL-1 response in autoimmune neuroinflammation and its regulation by the decoy receptor IL-1R2
(Applicant
Mufazalov, Ph.D., Ilgiz
)
Celluar metabolism of Treg in the control of chronic inflammatory diseases
(Applicant
Sparwasser, Tim Dominik
)
Deciphering functional heterogeneity within the embryonic intestinal stem cell progenitors in health and disease
(Applicant
Soshnikova, Natalia
)
Deciphering the tubulin code of dendritic cell homeostasis and function
(Applicant
Clausen, Björn
)
Dissecting the function of B cell in sporadic and colitis-associated colon cancer
(Applicant
Hövelmeyer, Nadine
)
Mechanismen der Bl-1/Bcl-2-vermittelten Reduktion des ER-Kalziumgehalts und der damit verbundenen antipoptotischen Wirkung
(Applicant
Methner, Axel
)
Regulatory T Cells and Th17 Cells in Autoimmune Brain Inflammation
(Applicant
Waisman, Ari
)
Role and therapeutic potential of different skin and lymph node-resident dendritic cell subsets to control cutaneous leishmaniasis in mice
(Applicant
von Stebut-Borschitz, Ruth Esther
)
Sensor, channel, pump and leak - TMBIM6 assembles a multi-protein complex that governs the Ca2+ content of the endoplasmic reticulum
(Applicant
Methner, Axel
)
The role of Fas and IL-6 in experimental autoimmune encephalomyelitis
(Applicant
Waisman, Ari
)
The role of IL-1 signaling in the regulation of microglia development and function
(Applicant
Waisman, Ari
)
The role of NECAB2 in brain physiology and in Huntington s disease
(Applicant
Methner, Axel
)
The role of the deubiquitinating enzymes Cyld and A20 in B cell lymphomagenesis
(Applicant
Hövelmeyer, Nadine
)
The role of the Fe/S cluster protein CISD1 in Parkinson’s disease
(Applicant
Methner, Axel
)
TMBIM5 is a Ca2+ channel in the inner mitochondrial membrane
(Applicant
Methner, Axel
)
Zelluläre Quellen und funktionelle Signifikanz von IL-6 bei der Entstehung autoreaktiver T Zell-Antworten im peripheren Immunkompartiment und im zentralen Nervensystem
(Applicants
Korn, Thomas
;
Waisman, Ari
)
Research Units
Completed projects
Role and Function of Microglia Cells in Autoimmune CNS Inflammation
(Applicant
Waisman, Ari
)
Priority Programmes
Current projects
Contributions of ubiquitin signaling to the maintenance of mitochondrial import channels
(Applicants
Methner, Axel
;
Ulrich, Ph.D., Helle
)
Crosstalk between ferroptosis and sarmoptosis
(Applicant
Methner, Axel
)
The deubiquitinating enzymes CYLD and A20 as gate keepers of central nervous system homeostasis
(Applicant
Waisman, Ari
)
Completed projects
Relevance of osteal macrophages in bone remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
The role of CXCR2-ligands for neutrophil mobilization from the bone marrow to peripheral sites
(Applicants
Gunzer, Matthias
;
Waisman, Ari
)
The role of ILC3 in autoimmune inflammation
(Applicant
Waisman, Ari
)
Thiol switches controlled by the glutathione-S-transferase GDAP1
(Applicants
Methner, Axel
;
Tenzer, Stefan
)
Heisenberg Grants
Current projects
Molecular mechanisms of intestinal stem cell specification, maintenance and differentiation during development and disease
(Applicant
Soshnikova, Natalia
)
Reinhart Koselleck Projects
Current projects
TRACINg: T-Cell Reactivation by Antigen Presenting Cells In the Central Nervous System
(Applicant
Waisman, Ari
)
WBP Position
Completed projects
Defining the Role of Mitochondrial Dysfunction in Autism Spectrum Disorder
(Applicant
Rojas-Charry, Ph.D., Liliana
)
Collaborative Research Centres
Current projects
Integrated Research Training Group
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
Mechanisms controlling Th17 and regulatory T cells in the anti-Leishmania response
(Project Heads
von Stebut-Borschitz, Ruth Esther
;
Waisman, Ari
)
Mechanisms of IL-10 mediated tumor immune evasion in colorectal cancer development
(Project Heads
Clausen, Björn
;
Hövelmeyer, Nadine
)
Regulating Cellular Functions by Light-Gated Assembly of Phase-Separated Nanostructures (Optoaggregates)
(Project Heads
Landfester, Katharina
;
Methner, Axel
;
Weil, Tanja
)
Completed projects
GDAP1 is a redox sensor that controls cellular redox homeostasis by altering mitochondrial shape and function
(Project Head
Methner, Axel
)
Immunmodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells
(Project Heads
Clausen, Björn
;
Holtappels, Rafaela
)
The role of antigen presenting cells in tolerance and pathogenicity of CD8+ T cells during viral and parasitic infection
(Project Head
Waisman, Ari
)
The role of CYLD as a tumor suppressor gene
(Project Head
Waisman, Ari
)
Using conditional gene targeting to study apoptotic and inflammatory signals in a mouse model for multiple sclerosis
(Project Head
Waisman, Ari
)
Zentraler Zuständigkeitsbereich Versuchstiereinrichtung
(Project Head
Waisman, Ari
)
CRC/Transregios
Current projects
Central Tasks
(Project Head
Waisman, Ari
)
CK2 as a Molecular Switch Regulating Immunity and Tolerance by APC-dependent Induction of Treg cells
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
In situ reprogramming of dendritic cells for immunomodulation of CNS-specific Foxp3+ regulatory T cells
(Project Heads
Sahin, Ugur
;
Waisman, Ari
)
Integrated Research Training Group
(Project Heads
Berod, Ph.D., Luciana
;
Daniel, Carolin
)
Microbiota-induced intestinal Treg cells modulate neuroinflammation
(Project Heads
Benakis, Corinne
;
Regen, Tommy
)
Myeloid cell mediated vascular inflammation in psoriasis
(Project Heads
Karbach, Susanne Helena
;
Waisman, Ari
)
Regulation of Treg cell subsets and function by the atypical IkB protein Bcl-3
(Project Heads
Hövelmeyer, Nadine
;
Ohnmacht, Ph.D., Caspar
)
The role of non-canonical NF-κB signaling in Treg cells in tissue homeostasis and disease
(Project Heads
Kramer, Daniela
;
Waisman, Ari
)
Treg cells as modulators of gluten-induced inflammation in celiac disease
(Project Heads
Berod, Ph.D., Luciana
;
Schuppan, Detlef
)
TRR 355: Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments
(Spokesperson
Waisman, Ari
)
Completed projects
Genetic Manipulation of Mice and Generation of Humanized Mice
(Project Heads
Reifenberg, Kurt
;
Waisman, Ari
)
Interplay between pro-inflammatory cytokines and chromatin-remodeling enzymes in the regulation of central nervous system demyelination and repair
(Project Heads
Jacob, Claire
;
Waisman, Ari
;
Wettschureck, Nina
)
Regulatory T Cells and Th17 Cells in Autoimmune Brain Inflammation
(Project Head
Waisman, Ari
)
Role of IL-6 in shaping local immune milieus in the CNS
(Project Heads
Korn, Thomas
;
Waisman, Ari
)
Targets and mediators of IL-17 in mouse models of psoriasis and skin infection
(Project Heads
Kurschus, Ph.D., Florian
;
Waisman, Ari
)
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
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